severe – Page 12 – Communicable Diseases Research

A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria

A −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

Use of an HRP2-based rapid diagnostic test to guide treatment of children admitted to hospital in a malaria-endemic area of north-east Tanzania

HRP2 기반의 신속 진단 검사를 사용하여 탄자니아 북동부 말라리아 유행 지역에 입원한 아동의 치료를 안내하다

Article

Published on 2011-05-142024-08-26
Journal: Tropical Medicine & International Health [Category] 말라리아,

[키워드] hospital malaria Rapid diagnostic test severe
[DOI] 10.1111/j.1365-3156.2011.02737.x PMC 바로가기

Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42

Research

Published on 2010-05-172022-10-28
Journal: Virology Journal [Category] Coronavirus,

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

Research Article

Published on 2010-04-082022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype
[DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

Research Article

Published on 2010-02-052022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] acute lung injury acute respiratory distress acute respiratory syndrome advanced age age analyses Analysis anti-inflammatory action ARDS Author cause Comprehensive contributed coronavirus correlated develop different differential expression diminishe disease displaying exacerbated expression Gene genomic H5N1 host response IFN-β IL-8 in viral increase in individual individuals Infection Inflammation influenza A Innate Intervention life-threatening Lungs macaque macaques Microarray modulation molecular mRNA level NF-κB outcome pandemic pathogen Pathogenesis pathology Pathways Patient primate pro-inflammatory gene expression Protective provide reduce reduced Replication response reveal SARS-CoV SARS-CoV infection severe severe pathology severity shown significantly significantly more syndrome Treatment type I Type I IFN type I interferon viral infection viral replication viral respiratory virus infection virus replication without affecting
[DOI] 10.1371/journal.ppat.1000756 PMC 바로가기 [Article Type] Research Article

Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection

Research Article

Published on 2010-01-152022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] 2B4 cell 2B4 cells Activation aggravate antiviral genes antiviral signaling bronchial bronchial epithelial cell calu-3 cells cellular cloned complementary complex coronavirus detected detrimental dynamic epithelial epithelial cell line event expression found functional growth highlight Host Human identify IFN-stimulated gene IFN-β IFN-λ Immune-mediated Infected Inflammatory cytokine Inflammatory mediators Inflammatory responses Innate interferon interferon regulatory factor ISGs limit lung epithelial cell Lungs nuclear pathology post infection Protein Replication respiratory response resulting SARS pathogenesis SARS-CoV SARS-CoV infection secreting severe Signaling Support target these cell triggered
[DOI] 10.1371/journal.pone.0008729 PMC 바로가기 [Article Type] Research Article

Plasmodium malariae in Bangladesh

방글라데시의 말라리아 원충

Case Report

Published on 2010-01-012024-08-26
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene [Category] 말라리아,

[키워드] Bangladesh malaria PCR Plasmodium malariae rosetting severe
[DOI] 10.1016/j.trstmh.2009.06.014 PMC 바로가기 [Article Type] Case Report

MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem Cells

Research Article

Published on 2009-11-132022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] ACE2 Activation acute infectious disease acute respiratory syndrome Basis bronchoalveolar caused CD45 Cell cellular miRNA complex interaction coronavirus SARS-CoV Data analysis Deterioration develop diagnostic Disease progression downregulated downregulation enrichment analysis epithelial evade Factors host cell host–virus interaction immune Infection inflammatory chemokines interact knowledge lung lung failure lung tissue marker microRNA miRNA miRNAs molecular mechanism Mortality observation pathway Protein target pulmonary fibrosis Replication reveal SARS-CoV SARS-CoV infection severe spike Stage STEM stem cell subset suppress target target cell the SARS epidemic Transmission viral genome Viral transmission virus
[DOI] 10.1371/journal.pone.0007837 PMC 바로가기 [Article Type] Research Article

Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice

Research Article

Published on 2009-10-232022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] activate activated Activation Adaptive immune response allergic alveolar macrophage animal model Anti-viral Antigen Author BALB/c mice caused characterized correlated CoV dendritic cell dendritic cells deplete develop DLN draining lymph node Epidemic feature Human human disease human population humans immune response individual inefficient Infected Infection inhibitory inhibitory effect initial Liposome lung lymphopenia MA15 Macrophage mice morbidity and mortality mouse-adapted SARS-CoV Novel coronavirus occurred Patient Poor Prevent prolonged virus persistence PROTECT respiratory Respiratory disease response severe severe disease severe respiratory disease T cell response T cells Therapies TLR3 Toll-like receptor transfer treated virus virus clearance virus excretion virus-specific T cell
[DOI] 10.1371/journal.ppat.1000636 PMC 바로가기 [Article Type] Research Article

Distant Relatives of Severe Acute Respiratory Syndrome Coronavirus and Close Relatives of Human Coronavirus 229E in Bats, Ghana

Research

Published on 2009-09-012022-10-31
Journal: Emerging Infectious Diseases [Category] Coronavirus,

[키워드] 229E bat bats common cold virus Concentration coronavirus CoV CoVs detected Distant Fecal sample Ghana Hipposidero human coronavirus hypothese molecular clock morphology Prevalence relative Research respiratory RNA severe Severe acute respiratory syndrome tested virus viruses
[DOI] 10.3201/eid1509.090224 PMC 바로가기 [Article Type] Research