Disease severity of the first COVID-19 wave in Germany using reporting data from the national notification systemFocus Published on 2021-02-122022-10-30 Journal: Journal of Health Monitoring [Category] COVID-19, [키워드] affected age Analysis cardiovascular disease China Cluster Contact tracing country COVID-19 Descriptive analysis diabetes disease severity First wave Germany groups hospitalisation ICU infection control information initial intensive care laboratory-confirmed Lung diseases measure median men Mild MOST National NATIONAL NOTIFICATION SYSTEM Neurological disorder pandemic Pneumonia provide reported retrospective risk factor Robert Koch severity Severity of disease symptom onset virus [DOI] 10.25646/7170 PMC 바로가기 [Article Type] Focus
Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control studyImmunology Published on 2021-02-092022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] affected antibody Antibody titer Antibody titers antigens association AST Asymptomatic biochemical Bordetella pertussis case control study case-control study childhood children circulating circulating antibodies control group control groups Covid patients COVID-19 COVID-19 severity cross-protection D-dimer disease disease severity Evidence ferritin healthy controls healthy volunteers Hypothesis identify immune memory Infection infection markers less Level memory Mild pandemic patients with COVID-19 pneumococcus procalcitonin Protective Result rubella severity Severity of disease significantly increased significantly lower Support the disease vaccination Vaccinations Vaccine [DOI] 10.7717/peerj.10910 PMC 바로가기 [Article Type] Immunology
Severe Thrombocytopenia in a Pregnant Patient with Asymptomatic COVID-19 Infection: A Case ReportAnesthesiology Published on 2021-01-292022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Admission Asymptomatic bleeding Care Coagulation complete blood count contributing to coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 testing described etiology feature gestation highlight Infection invasive lowest occur Patient patient with COVID-19 Platelet Platelets positive postpartum hemorrhage preeclampsia Pregnancy pregnant report resulting risk Severity of disease Symptom thrombocytopenia [DOI] 10.7759/cureus.12990 PMC 바로가기 [Article Type] Anesthesiology
Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent IndividualsSARS-CoV-2 회복기 환자의 전신 및 점막 체액 면역의 특징 및 기능Immunology Published on 2021-01-282022-09-12 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, 진단, [키워드] antibody Antibody Response cohorts contribute convalescent individual correlated correlations COVID-19 Critical experiment function Hospitalization humoral immune response IgA IgA responses IgG Immunity individual Infection less magnitude mucosa mucosal mucosal immunity nasal natural infection neutralization phagocytosis public health reduced risk robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG serum severe disease Severity of disease Support systemic systems serology understanding Vaccine Vaccine development Virus neutralization [DOI] 10.3389/fimmu.2020.618685 PMC 바로가기 [Article Type] Immunology
Cost‐effectiveness of intensive care for hospitalized COVID-19 patients: experience from South AfricaResearch Article Published on 2021-01-222022-10-28 Journal: BMC health services research [Category] COVID-19, [키워드] adjusted Admission African Analysis approach calculated Cost‐effectiveness COVID-19 COVID-19 pandemic COVID-19 patient Critical care critical COVID-19 patient determine disability estimate evaluated Evidence Government Health health system hospitalized COVID-19 hospitals ICU indicated intensive care intensive care unit management mortality rates outcome Perspective Pragmatic Priority setting produced Public Hospital representing Result SARS-CoV-2 Severity of disease South South Africa threshold unit cost was determined were assessed [DOI] 10.1186/s12913-021-06081-4 PMC 바로가기 [Article Type] Research Article
Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial중증 코로나19 환자에서 이카티반트 및 C1 에스테라제/칼리크레인 억제제의 효능 및 안전성 평가: 3군 무작위 대조 시험 연구 프로토콜Study Protocol Published on 2021-01-202022-09-10 Journal: Trials [Category] 비임상, 임상, [키워드] accumulation ACE inhibitor ACE inhibitors ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models anti-inflammatory agents antibiotic antithrombotic therapy assigned binding bradykinin breath C1 esterase inhibitor cause Cell clinical clinical trial clinical trials cough COVID-19 Degradation dependent on driving Efficacy and safety eligible patient expressed Icatibant inactivation include Inflammatory inhibitor intravenously invasive ventilation leads lipopolysaccharide LPS lung lung inflammatory response Lungs mechanism mortality rates Non-invasive number Open-label oxygen parallel-group Pneumonia Pneumonitis Prophylactic Protein randomized clinical trial Randomized controlled trial Randomly receive reduce registry renal replacement therapy replacement therapy Respiratory failure SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients Severity of disease Side effect single-center standard care Study protocol subcutaneously supplemental oxygen the cells Universal vasopressor support viral-induced virus [DOI] 10.1186/s13063-021-05027-9 PMC 바로가기 [Article Type] Study Protocol
Age is not the only risk factor in COVID-19: the role of comorbidities and of long staying in residential care homesResearch Article Published on 2021-01-152022-10-27 Journal: BMC Geriatrics [Category] COVID-19, [키워드] Admission age analyzed association Blood Bonferroni correction Care categorical variable caused clinical outcomes Comorbidities Comorbidity computer tomography COVID 19 develop diagnosis of COVID-19 disease elderly Elderly patient examined Factors FiO2 Fisher’s exact test Hospital stay increased mortality index inflammatory activity information inspired oxygen fraction Kaplan-Meier method Laboratory tests Logistic regression LOS manifestation Mann-Whitney U test mortality rate multiple comorbidities multiple group multivariate Occurrence outbreak outcome oxygen P/F PaO2 Patient patients patients older performed PSI radiological finding RANK Residential care homes Result Retrospective study risk factor risk stratification Rome SARS-CoV-2 Severity of disease Sex single-center survival susceptible Symptom Test the disease two group university variables viral shedding Wilcoxon signed-rank test [DOI] 10.1186/s12877-021-02013-3 PMC 바로가기 [Article Type] Research Article
Age is not the only risk factor in COVID-19: the role of comorbidities and of long staying in residential care homesResearch Article Published on 2021-01-152022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, MERS, [키워드] Admission age analyzed association Blood Bonferroni correction Care categorical variable caused clinical outcomes Comorbidities Comorbidity computer tomography COVID 19 develop diagnosis of COVID-19 disease elderly Elderly patient examined Factors FiO2 Fisher’s exact test Hospital stay increased mortality index inflammatory activity information inspired oxygen fraction Kaplan-Meier method Laboratory tests Logistic regression LOS manifestation Mann-Whitney U test mortality rate multiple comorbidities multiple group multivariate Occurrence outbreak outcome oxygen P/F PaO2 Patient patients patients older performed PSI radiological finding RANK Residential care homes Result Retrospective study risk factor risk stratification Rome SARS-CoV-2 Severity of disease Sex single-center survival susceptible Symptom Test the disease two group university variables viral shedding Wilcoxon signed-rank test [DOI] 10.1186/s12877-021-02013-3 PMC 바로가기 [Article Type] Research Article
A Matter of Caution: Coagulation Parameters in COVID-19 Do Not Differ from Patients with Ruled-Out SARS-CoV-2 Infection in the Emergency DepartmentOriginal Article Published on 2021-01-062022-10-29 Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19, [키워드] Abnormalities activated acute respiratory syndrome Admission analyzed Anticoagulant clinical evaluation clinically suspected Coagulation Coagulation parameters Coagulopathy Cohort comparable coronavirus coronavirus disease courses COVID-19 COVID-19 diagnosis D-dimer Department diagnostic value diagnostics Disease progression Emergency emergency department enrolled Excessive activation fibrinogen group in-depth analysis increased risk initial INR intensive care unit Laboratory parameters matter Moderate COVID-19 Mortality no significant difference non-COVID-19 cohort parameter Patient patients with COVID-19 PCR Platelets polymerase chain positive presenting Prevalence Protein protein S respiratory symptoms risk stratification SARS-CoV-2 Severity of disease shown subsequent swabs tested thrombosis [DOI] 10.1055/s-0040-1722612 PMC 바로가기 [Article Type] Original Article
Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sexCOVID-19의 사이토카인 방출 증후군: 선천성 면역, 혈관 및 혈소판 병원성 요인은 질병의 중증도와 성별이 다릅니다.Clinical Trial Published on 2021-01-012022-09-25 Journal: Journal of leukocyte biology [Category] SARS, 바이오마커, 임상, 진단, [키워드] Activation acute illness addition age Analysis analyzed association Biomarker CD40L Characteristics clinical feature Clinical features Cluster Cohort controls COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines disease disease pathology disease severity examined Factor females FGF fibroblast fibroblast growth factor growth Growth factors Health Health crisis highlight Hospitalized ICU admission identify IL-13 IL-4 immune immune response immune responses Immunopathogenesis Inflammatory cytokines Innate Innate immunity IP10 male pathogenic Patient PDGF Plasma cytokine Platelet platelet-derived growth factors Protein public health crisis risk severe disease Severity of disease Sex significant increases in syndrome Treatment understanding Vascular Vasculitis with COVID-19 [DOI] 10.1002/JLB.3COVA0820-410RRR PMC 바로가기 [Article Type] Clinical Trial