Circadian clock modulating small molecules repurposing as inhibitors of SARS-CoV-2 M pro for pharmacological interventions in COVID-19 pandemicCOVID-19 전염병에 대한 약리학적 개입을 위한 SARS-CoV-2 M pro 억제제로 용도 변경되는 소분자를 조절하는 24시간 주기 시계Article Published on 2021-07-012022-09-11 Journal: Chronobiology international [Category] SARS, 신약개발, 치료제, [키워드] approach caused circadian clock Circadian clock-modulating molecules Coronavirus infection Coronavirus infections COVID-19 COVID-19 pandemic drug target expected health emergency inhibiting inhibitor inhibitors inhibitors of SARS-CoV-2 M pro main protease modulating MPro pandemic pharmacological intervention polyprotein Prevent protease Proteolytic processing Replication replication of SARS-CoV-2 required SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 replication small molecule Spread SRT2183 targeted therapy targeting the SARS-CoV-2 Therapeutics Transcription Treatment Viral RNA [DOI] 10.1080/07420528.2021.1903027 PMC 바로가기 [Article Type] Article
Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World DataCOVID-19 임상 시험의 약물: 체외 분석 및 실제 데이터를 사용하여 운반체 매개 약물-약물 상호작용 예측Article Published on 2021-07-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 임상, 치료제, [키워드] accelerated ADRS Adverse drug reaction Adverse drug reactions Chloroquine clinical clinical investigation clinical study clinical trial clinical trials clinically concentrations concomitant medications coronavirus disease Coronavirus disease 2019 COVID-19 criteria database determine drug drug-drug interaction Efficacy Electronic health records expressing Future HEK293 cell HEK293 cells Hydroxychloroquine inhibit membrane vesicle Numerous Older patients with COVID-19 predict predicted real-world data Regulatory Authorities regulatory authority representing risk Risk assessment Sildenafil small molecule small molecule drug target targets Treatment [DOI] 10.1002/cpt.2236 PMC 바로가기 [Article Type] Article
Potential Therapeutic Targets and Vaccine Development for SARS-CoV-2/COVID-19 Pandemic Management: A Review on the Recent UpdateSARS-CoV-2/COVID-19 팬데믹 관리를 위한 잠재적인 치료 목표 및 백신 개발: 최근 업데이트에 대한 검토Review Published on 2021-06-302022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibodies antibody Beta cause caused China city clinical trials common cold Coronaviridae family coronavirus disease Coronavirus disease 2019 Coronavirus-2 country CoV COVID-19 develop development disease effort epicenter Health Organization help highly pathogenic Hope Host Inactivated Vaccines Integrative analysis Interaction management Multiple nucleic acid outbreak pandemic peptide peptides Phase 3 phase 3 clinical trials Potential Prophylaxis recent respiratory respiratory symptom respiratory symptoms review Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 small molecule small molecule drugs target the Coronaviridae the disease therapeutic Therapeutic approach therapeutic strategy therapeutic targets treat Treatment Vaccine Vaccine development Vaccines virus WHO World Health Organization Wuhan [DOI] 10.3389/fimmu.2021.658519 PMC 바로가기 [Article Type] Review
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entryTMPRSS2 발현을 위한 고처리량 스크린으로 SARS-CoV-2 진입을 제한할 수 있는 FDA 승인 화합물 식별Article Published on 2021-06-232022-09-10 Journal: Nature Communications [Category] MERS, SARS, 비임상, [키워드] 2019-nCoV ACE2 breath Cell cell entry cell surface receptor clinical trial Compound compounds Concentration concentrations coronavirus COVID-19 disease COVID-19 infection DCAF1 DDB1 Degradation dependent on drug E3 ubiquitin ligase Effect entry of SARS-CoV-2 epithelial cells expression global pandemic halofuginone help High-throughput screening homoharringtonine Host host protease host proteases human clinical trial human clinical trials Human plasma identify in vitro library limit lung epithelial cell modulate pathogenic coronavirus pharmacokinetic data proteasome Protein reduce reducing responsible SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 glycoprotein SARS-COV-2 infection Screen Serine serine protease serine protease TMPRSS2 small molecule Small molecules spike stability surface expression surface receptor the cell TMPRSS2 TMPRSS2 expression TMPRSS2 level TMPRSS2 levels TMPRSS2 protein [DOI] 10.1038/s41467-021-24156-y PMC 바로가기 [Article Type] Article
SARS-CoV-2: Origin, Evolution, and Targeting InhibitionSARS-CoV-2: 기원, 진화 및 표적 억제Review Published on 2021-06-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 진단, [키워드] (RdRp ACE2 acute respiratory diseases acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed angiotensin angiotensin converting enzyme antibodies antibody bind carried caused China comparison complex structure coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G described drug effective enzyme Evolution help host cell in viral Infection inhibit inhibition inhibitor Invasion involved mechanism MPro mutant Neutralizing antibodies neutralizing antibody non-structural proteins origin outbreak pandemic pathogenic pathogenic mechanism physiological protease Protein proteolytic RdRP receptor recognize Replication respiratory respiratory diseases responsible RNA-dependent RNA polymerase S protein SARS-CoV-2 second wave severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small molecule small molecule inhibitor Small molecule inhibitors Spread Structure targeting targeting inhibition therapeutic target transcription processes Viral viral genome replication viral invasion Viral RNA Wuhan [DOI] 10.3389/fcimb.2021.676451 PMC 바로가기 [Article Type] Review
More Is Always Better Than One: The N-Terminal Domain of the Spike Protein as Another Emerging Target for Hampering the SARS-CoV-2 Attachment to Host CellsPerspective Published on 2021-06-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antibody approved attachment Better cavity mapping coronavirus Coronavirus disease 2019 COVID-19 defined diagnostics domain effective therapy galectin inhibitors glycoprotein host cells immune response induce N-terminal domain Neutralizing antibodies Perspective S1-NTD SARS-CoV-2 single-stranded RNA virus small molecule Spike protein target the SARS-CoV-2 the Spike therapeutic Vaccine variant virus [DOI] 10.3390/ijms22126462 PMC 바로가기 [Article Type] Perspective
Early Returns on Small Molecule Therapeutics for SARS-CoV-2SARS-CoV-2에 대한 저분자 치료제의 조기 수익Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 신약개발, 치료제, [키워드] approach breadth clinical testing Computational approaches COVID-19 pandemic determine effort Extraordinary identify molecule Pandemics Potential treatment potential treatments preparation progression return SARS-CoV-2 SARS-COV-2 infection Scientific community small molecule Therapeutics treat [DOI] 10.1021/acsinfecdis.0c00874 PMC 바로가기 [Article Type] Article
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular MechanismsReview Published on 2021-06-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activate activated Activation alveolar appear approved attenuate autophagy canonical Cell cell type cellular cellular proliferation change characterized clinical trial compassionate use Cytokines described disorders distribution Endoplasmic reticulum epithelial Evidence excessive inflammation expression FGF fibroblast fibrosis growth factor idiopathic pulmonary fibrosis (IPF) IL-11 IL-13 IL-6 ILD in vitro in vivo model indicate inhibit Interaction interstitial inflammation interstitial lung disease (ILD) isoform isoforms JAK inhibitor JAK/STAT JAK/STAT pathway JAK2/STAT3 Janus kinases (JAK) lung Lung disease lung disorder Lung fibrosis lung tissue molecular monoclonal antibody over-expressed pathway Pathways PDGF Phosphorylation predominant proliferation pulmonary fibrosis recent role SARS-CoV-2 virus signal transducer and activator of transcription (STAT) small molecule Stress TGF-β1 [DOI] 10.3390/ijms22126211 PMC 바로가기 [Article Type] Review
A Bioluminescent Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and In VitroArticle Published on 2021-06-022022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antibodies bioluminescent bioluminescent biosensor biosensor cellular receptor Coronavirus-2 COVID-19 develop Drug discovery drugs evaluate evaluated in vitro Interaction living cell mutant mutant virus NanoBiT peptide RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 RBD significantly small molecule the SARS-CoV-2 therapeutic drugs virus–host interaction [DOI] 10.3390/v13061055 PMC 바로가기 [Article Type] Article
Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 PatientsArticle Published on 2021-06-022022-10-04 Journal: SLAS discovery : advancing life sciences R & D [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] 384-well format acute respiratory syndrome Analysis antifibrotic antifibrotic therapy Apoptosis application applied approved drug automated Autopsy Candidates Cell cell differentiation Confirmed COVID-19 COVID-19 pandemic COVID-19 patient current Data analysis Diseases drug ECM effective elevated Extracellular matrix fibroblast fibrosis growth hallmark Health high-content screening Human human lung lung Lung fibrosis medical need Middle East Migration mitigate Mortality network analysis pathway phenotypic phenotypic drug discovery previous study Prognosis proliferation Rapid representing repurposing respiratory disorder scarring screened Screening small molecule syndrome therapeutic Treatment ventilator with COVID-19 [DOI] 10.1177/24725552211019405 PMC 바로가기 [Article Type] Article