BCEPS: A Web Server to Predict Linear B Cell Epitopes with Enhanced Immunogenicity and Cross-ReactivityBCEPS: 향상된 면역원성과 교차 반응성으로 선형 B 세포 에피토프를 예측하는 웹 서버Article Published on 2021-10-142022-09-11 Journal: Cells [Category] MERS, SARS, 치료기술, 치료제, [키워드] Accessibility Accuracy antibody antigen-specific antibody antigens B cell epitope B cell epitopes B cells best conformational cross-reactive antibodies cross-reactive antibody dataset detect ectodomain ectodomains enhanced epitope Epitopes flexibility hydrophilicity identify IEDB Immune Epitope Database immunogenic immunogenicity independent linear linear B machine learning machine learning model membrane protein Membrane proteins MHC II molecules N-glycosylation site Neutralizing antibodies peptide-based vaccines predicted prediction Protein protein structures reached retrieved SARS-CoV-2 SARS-CoV-2 spike protein server specific antibodies spike Spike protein structures Support support vector machine the SARS-CoV-2 Web web server [DOI] 10.3390/cells10102744 PMC 바로가기 [Article Type] Article
COVID-19 Presenting as Recurrent Pericardial EffusionInternal Medicine Published on 2021-10-112022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect affecting Altered mental status Analysis appear association capillary leakage Case report cells chest pain coronavirus coronavirus disease covid and heart COVID-19 COVID-19 cases COVID-19 infection creating deleterious effect demonstrated disease Effects effusion Evidence global pandemic inflammatory markers Inflammatory response moderate occur Patient pericardial effusion pericardial window pleuritic positive Recurrent resulting SARS-CoV-2 sars-cov-2 (severe acute respiratory syndrome coronavirus -2) structures Symptom with COVID-19 Wuhan, China [DOI] 10.7759/cureus.18652 PMC 바로가기 [Article Type] Internal Medicine
Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition인간 심근세포의 고효율 SARS-CoV-2 감염: 스파이크 단백질 매개 세포 융합 및 억제Virus-Cell Interactions Published on 2021-10-062022-09-10 Journal: Journal of Virology [Category] MERS, SARS, 변종, [키워드] 2019 aberrant host response accounted ACE2 Activation activity Acute respiratory infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Autopsy block canonical cardiac cardiac complication Cardiac complications cardiac damage cardiac tropism cardiovascular complication cardiovascular complications catalytic site Cell Cell fusion cell lines cell surface cell-cell fusion cells cleavage cleavage site coding coronavirus coronavirus disease correlated COVID-19 COVID-19 patient cytopathic Cytopathic effect cytoplasm cytoplasmic tail direct infection disrupt Drug discovery efficient examined exceeded Express expressed expression vector fluorescent furin furin cleavage motif furin-like protease furin-like proteases fused fusing fusion fusion inhibition green fluorescent protein Human human cardiomyocyte in vitro model inactive Infection inhibition Lungs mechanism monomeric mRNA mutant Mutation Myocardium occur other coronavirus other coronaviruses parental Particle patients peptide-based platform pluripotent stem cell-derived cardiomyocytes protease Protein protein cleavage Proteolytic processing receptor replicate required respiratory respiratory infection SARS-CoV-2 SARS-COV-2 infection Serine serine 2 severe acute respiratory syndrome Coronavirus spike Spike protein Spread structures Syncytia systemic inflammation the spike protein These data thrombosis tissue TMPRSS2 Transformed cell transmembrane transmembrane protease serine 2 tropism of SARS-CoV-2 Vesicle Viral viral replication viral transcript viral transcription viral transcripts Virus-like particle virus-like particles viruses [DOI] 10.1128/JVI.01368-21 PMC 바로가기 [Article Type] Virus-Cell Interactions
Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agentsEphedra Sinica STAPF의 활성 성분은 ACE2와 SARS-COV-2 RBD 사이의 상호 작용을 방해합니다 : 강력한 COVID-19 치료제Article Published on 2021-10-052022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 치료제, [키워드] 293T-ACE2 4-hydroxy-6-methoxyquinoline-2-carboxylic acid (PubChem CID: 22017520) 4-hydroxyquinoline-2-carboxylic acid (PubChem CID: 3845) 4,6-dihydroxyquinoline-2-carboxylic acid (PubChem CID: 440752) ACE2 ACE2-RBD activity alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asia Asthma binding domain Calu calu-3 cells carboxylic acid carried cells Chinese Cold component Compound compounds cough COVID-19 COVID-19 therapeutic agent Deterioration disrupt disrupting docking domain effort ephedra Ephedra sinica Ethanol HPLC hydrogen Hydrogen bond hydroxy indicated inhibit inhibit SARS-CoV-2 inhibiting Inhibition assays inhibitory activity Interaction Isolation knock-out Lung diseases material mechanism molecular docking NMR observé potent potential therapeutic agent potential therapeutic agents PPI PPI inhibitor Prevent protein-protein interaction provided pseudoviruses PubChem quinoline Quinoline-2-carboxylic acid S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus SARS-CoV-2 virus infection Spike protein SPR Structure structures suggested surface plasmon surface plasmon resonance Symptom TCM the SARS-CoV-2 therapeutic agents these compound these compounds Traditional Chinese medicine treat viropexis virus infection were used [DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article
When Covid-19 first struck: Analysis of the influence of structural characteristics of countries – technocracy is strengthened by open democracyResearch Article Published on 2021-10-042022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] absence age Analysis approach Characteristics Cluster Context correlation country death Depth Desk Effects enrolment Evidence facilitate facilitated Factor Factors feature Features finding Government had no Health Health services health system identify implication influence Interpretation majority measure moderate Multiple regression National nine notable outcome pandemic Population positive profiles resources respond responses seeking strength structures therapeutic Volume [DOI] 10.1371/journal.pone.0257757 PMC 바로가기 [Article Type] Research Article
Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCRHLA-A*02:01에서 제시한 지배적인 SARS-CoV-2 스파이크 유래 에피토프의 분자 기반은 공공 TCR에서 인정했습니다.Article Published on 2021-10-032022-09-11 Journal: Cells [Category] MERS, SARS, 변종, [키워드] activate antibodies Basis binding CD8+ T cell CD8+ T cells clearance complex COVID-19 recovered COVID-19 recovered patients Critical dominant epitope epitope presentation help HLA-A HLA-A*02:01 immune system individual individuals Interaction lack molecular basis peptide Public public TCR recognition SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus Structure structures T cell T cell receptor T cells TCR the SARS-CoV-2 virus Viral virus while X-ray crystallography YLQ peptide [DOI] 10.3390/cells10102646 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 Variants with Nucleic Acid Therapeutic Nanoparticle ConjugatesBrief Report Published on 2021-10-012022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acid Analysis Antisense oligonucleotide Antisense oligonucleotides antiviral drug coding region conjugate conservation conserved contributing to Critical current disadvantage drug homopurine nanomedicines nanoparticle oligomers oligonucleotides palindrome predict predicted produced Region Regulatory representing resulting RNAfold SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Structure structures targeting TFO Vaccine variant variants viral genome Viral proteins was performed was used [DOI] 10.3390/ph14101012 PMC 바로가기 [Article Type] Brief Report
Fragment-based in silico design of SARS-CoV-2 main protease inhibitorsSARS-CoV-2 주요 프로테아제 억제제의 단편 기반 in silico 설계Article Published on 2021-10-012022-09-11 Journal: Chemical biology & drug design [Category] SARS, 신약개발, 치료제, [키워드] 3CLpro approach AutoDock AutoDock vina binding binding affinity binding mode binding pocket co-crystallized Compound conformation conformations coronavirus Coronavirus COVID-19 crystal structure domain Drug discovery eight fragment fragment-based drug discovery generate Glide in silico inhibitor interactions linear combination linker main protease Mpro 3CLpro MD simulation MPro multivalency. Precision protease Protein Data Bank provided SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 replication screened selected small molecule Small molecules starting point Structure structures suggested therapeutic strategy were used X-ray X-ray crystal structure [DOI] 10.1111/cbdd.13914 PMC 바로가기 [Article Type] Article
A method for intuitively extracting macromolecular dynamics from structural disorderArticle Published on 2021-09-172022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] accounted Analysis approach conformations Cryo-electron microscopy cryo-EM structures disorder example Factors Hierarchical hypothese Implications information macromolecular molecular molecular mechanisms parameter Proteins Quantitative SARS-CoV-2 SARS-CoV-2 proteins STEAP4 Structural analysis structural biology Structure Structure determination structures temperature [DOI] 10.1038/s41467-021-25814-x PMC 바로가기 [Article Type] Article
Structures of synthetic nanobody–SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interactionResearch Article Published on 2021-09-162022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] accompanied ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome angiotensin-converting enzyme 2 antibody BSA, buried surface area CCs, correlation coefficients CDR1, complementarity-determining region 1 CDR2, complementarity-determining region 2 CDR3, complementarity-determining region 3 complementarity-determining region complexes conformational coronavirus cryo-EM cryo-EM structure crystal structure Crystallography CTF, contrast transfer function difference domain enzyme explained FIVE indicate interact Interaction PDB, Protein Data Bank RBD RBD variant RBD, receptor-binding domain S-6P, HexaPro S S, spike SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography single-domain antibody (sdAb, nanobody) Spike protein SPR, surface plasmon resonance Spread Structure structures surface plasmon resonance (SPR) sybody synthetic nanobodies the RBD the SARS-CoV-2 Trimeric spike protein unliganded variant X-ray [DOI] 10.1016/j.jbc.2021.101202 PMC 바로가기 [Article Type] Research Article