Real-World Effectiveness of Remdesivir in Adults Hospitalized With Coronavirus Disease 2019 (COVID-19): A Retrospective, Multicenter Comparative Effectiveness Study코로나바이러스 질병 2019(COVID-19)로 입원한 성인에서 렘데시비르의 실제 효과: 후향적, 다기관 비교 효과 연구Multicenter Study Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료제, [키워드] 19 2 28-day mortality 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted hazard ratio Clinical improvement Comparative Control controls coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 patients death Diagnosis dose Effectiveness healthcare Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients ICD-10 individual less likelihood low-flow oxygen male median age Mortality oxygen Patient patients Positive test Primary outcome real recipient Remdesivir retrospective routine SARS SARS-CoV-2 secondary outcome severe acute respiratory syndrome Coronavirus severely ill patient significantly significantly more Support symptomatic the United State Therapeutics Treatment United States unlikely world effectiveness. [DOI] 10.1093/cid/ciab1035 PMC 바로가기 [Article Type] Multicenter Study
SARS-CoV-2 RBD-Specific Antibodies Induced Early in the Pandemic by Natural Infection and Vaccination Display Cross-Variant Binding and InhibitionArticle Published on 2022-08-242022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding acute respiratory syndrome angiotensin-converting enzyme 2 antibody approved Beta binding BNT162b2 ChAdOx1 nCoV-19 circulating collected coronavirus country COVID-19 cross-reactive cross-reactivity Denmark display dose Efficacy examined Gamma greater IgG Immunity induced infected with SARS-CoV-2 inhibited inhibition inhibitory less mechanisms natural natural infection omicron Oxford-AstraZeneca pandemic Pfizer-BioNTech receptor Receptor binding domain reduced regimen response SARS-CoV-2 Strains subject subjects susceptibility sustained symptomatic transmission rate vaccination Vaccine vaccine candidate variant variants of concern were used wild-type [DOI] 10.3390/v14091861 PMC 바로가기
Facing the Omicron variant-how well do vaccines protect against mild and severe COVID-19? Third interim analysis of a living systematic reviewArticle Published on 2022-08-242022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] 95% CI acute respiratory syndrome Against approved booster booster dose booster vaccination characterized coronavirus coronavirus disease COVID-19 COVID-19 vaccine Critical death dominant variant Effectiveness estimate European evaluated Evidence Hospitalization ICU admission Immunity immunization indicated Infection interim analysis long-lasting Mild moderate omicron Omicron variant outcomes Participants performed PROTECT ranged receiving remained risk of bia robust SARS-CoV-2 SARS-COV-2 infection searched severe COVID-19 study heterogeneity symptomatic systematic review the SARS-CoV-2 union vaccination Vaccine vaccine effectiveness variant variant of concern website [DOI] 10.3389/fimmu.2022.940562 PMC 바로가기
Summary of Guidance for Minimizing the Impact of COVID-19 on Individual Persons, Communities, and Health Care Systems – United States, August 2022Article Published on 2022-08-192022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, 치료제, [키워드] acute illness age Antiviral agents approach Care cause CDC changes in circulating variants conditions COVID-19 COVID-19 illness current death effective effort expand exposure Health high risk Hospitalization Immunity Immunocompromised Impact increase individual Infection information Mask measure Measures medical condition monoclonal antibodies nonpharmaceutical intervention Nonpharmaceutical interventions preexposure prophylaxis Prevent PROTECT public health receive recommendation reduce reduced reducing Respirator risk SARS-CoV-2 symptomatic System therapeutic Treatment United States vaccination Vaccine Vaccines Ventilation virus [DOI] 10.15585/mmwr.mm7133e1 PMC 바로가기
Incidence of thromboembolic complications in hospitalized COVID-19 patients in a medical ward in Japan: A single-center retrospective and prospective observational studyObservational Study Published on 2022-08-192022-10-05 Journal: Medicine [Category] 임상, [키워드] 95% CI addition Admission age Asian Asymptomatic body mass index complications of COVID-19 conducted COVID-19 COVID-19 patient Critical determine died events hallmark higher risk hospital hospitalized COVID-19 patient identify incidence intensive care IQR Ischemia Japan Japanese limb median Mild moderate Myocardial infarction occurred Patient Prevalence Primary outcome prospective cohort study prospective observational study Prospective Study retrospective Severe case severe COVID-19 severe COVID-19 patient severity of COVID-19 single-center stroke symptomatic the median thromboembolic complication thromboembolic complications transferred Venous Thromboembolism women [DOI] 10.1097/MD.0000000000029933 PMC 바로가기 [Article Type] Observational Study
Evaluation of the effectiveness of surveillance policies to control the COVID-19 pandemic in São Paulo, BrazilArticle Published on 2022-08-172022-11-16 Journal: Global Health Research and Policy [Category] 치료기술, [키워드] Analysis Asymptomatic Brazil change changes in characterized Concentration conducted COVID-19 COVID-19 pandemic criteria database demographics disease Effectiveness effort evaluate genomic genomic sequence GISAID greater Health highlight Hospitalized increase in information Isolation Laboratory limit Local Molecular tests outcome outcomes pandemic Population Prevalence public health reductions in Regression model Result RHD RT-PCR RT-PCR public health testing policies RT-PCR test RT-PCR testing significantly state statistically significant Surveillance symptomatic Testing the mean These data Treatment virus Volume [DOI] 10.1186/s41256-022-00260-4 PMC 바로가기
SARS-CoV-2 antibody progression and neutralizing potential in mild symptomatic COVID-19 patients – a comparative long term post-infection studyArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute infections addition Antibody titer block CLIA clinician Cohort comparability comparable convalescent COVID-19 disease COVID-19 patient Cutoff diagnostics ELISA FIVE help immune immune response increasingly individual immune response Infection information Laboratory long-COVID long-term assay comparison Mild mild progression COVID-19 mild SARS-CoV-2 infection Molecular diagnosis neutralization Neutralizing neutralizing potential Occurrence offered pandemic participant Participants Patient Post-infection progression quantification quantification immune response. Rapid SARS-CoV-2 SARS-CoV-2 antibody serological serological test specific antigen Support Symptom symptomatic vaccination Vaccine WHO [DOI] 10.3389/fimmu.2022.915338 PMC 바로가기
Monoclonal antibodies for mild-to-moderate COVID-19 in multiple sclerosis: A case series다발성 경화증에서 경증에서 중등도의 COVID-19에 대한 단일클론항체: 사례 시리즈Article Published on 2022-08-152022-09-12 Journal: Journal of the neurological sciences [Category] MERS, 진단, 치료제, [키워드] absence anti-CD20 anti-SARS-CoV-2 antibody case sery change COVID-19 COVID-19 vaccine disease FIVE Mild-to-moderate monoclonal antibodies monoclonal antibody Multiple multiple sclerosis reduced reported symptomatic treated Treatment [DOI] 10.1016/j.jns.2022.120306 PMC 바로가기 [Article Type] Article
Breakthrough COVID-19 Infection During the Delta Variant Dominant Period: Individualized Care Based on Vaccination Status Is NeededArticle Published on 2022-08-152022-11-16 Journal: Journal of Korean medical science [Category] SARS, 변종, [키워드] abnormality age analyzed Breakthrough infection chest X-ray Clinical characteristics clinical feature Comorbidity coronavirus disease COVID-19 COVID-19 patient COVID-19 vaccination Delta Diabetes Mellitus elevated group Hospitalized hospitalized COVID-19 patient initial lactate dehydrogenase less National numbers of patient Older oxygen Oxygen therapy Patient patients progression proportion protective factor risk risk factor SARS-CoV-2 Severe Progression. solid cancer status symptomatic two groups vaccination were assessed X-ray [DOI] 10.3346/jkms.2022.37.e252 PMC 바로가기
Plasmonic Fluor-Enhanced Antigen Arrays for High-Throughput, Serological Studies of SARS-CoV-2SARS-CoV-2의 높은 처리량, 혈청학적 연구를 위한 플라즈몬 형광 강화 항원 어레이Article Published on 2022-08-122022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 96-well plate acute infection Antigen antigenic antigenic drift Bioscience Characteristics clinical sensitivity coordination COVID-19 pandemic Critical current diagnostics eight evaluate fluorescent highlight IgA IgG IgM Laboratory limitation limitations management microarray analysis microplate reader multiplex Outbreaks Patient Patient management plasmonics public health ranged reagents reminder response resulting Sample SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 detection SARS-CoV-2 positive patients Screening sensitivities sensitivity serological assays serological response serological studies SEROLOGICAL STUDY Serological testing serology several limitations specificity subset symptomatic used to evaluate Volume was performed were used [DOI] 10.1021/acsinfecdis.2c00086 PMC 바로가기 [Article Type] Article