Pneumococcal DnaJ modulates dendritic cell-mediated Th1 and Th17 immune responses through Toll-like receptor 4 signaling pathwayarticle Published on 2017-02-282024-09-01 Journal: Immunobiology [Category] 폐렴구균 감염증, [키워드] dendritic cell DNAJ MAPKs NF-κB PI3K-Akt S. pneumonia Th1 Th17 TLR4 [Article Type] article
Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease유전 변이는 점막 염증 질환에서 T-bet 결합 및 유전자 발현을 변경합니다Research Article Published on 2017-02-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect alleles Alter alteration Arthritis association autoimmune conditions Autoimmune disease Autoimmune diseases Autoimmunity autoinflammatory disease binding binding site Cancer CD4+ T cell CD4+ T cells celiac disease certainty ChIP ChIP-seq condition contribute Crohn’s disease decreased expression disease disease-associated distal DNA elements environmental factors eQTL examined exons expression expression quantitative trait locus Gene Expression Genetic Genetic polymorphism genetic polymorphisms Genetic variant genetic variants Genetic variation Genome-wide association studies helper cell heterozygous identify IL18RAP immune response in vitro in vivo increased risk individual Infection Inflammatory inflammatory disease Inflammatory diseases Lineage locus majority mechanism modulating molecular mechanism mucosal nucleotide Other polarization polymorphism protective immunity Protein psoriasis Quantitative quantitative trait locus Region regulate Regulatory represse reveal rheumatoid arthritis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs subsequent susceptibility susceptibility to infections T cell T cells T helper cell TBX21 Th1 transcription factor transcription factors transcriptional ulcerative colitis underlie variant [DOI] 10.1371/journal.pgen.1006587 PMC 바로가기 [Article Type] Research Article
Pertussis: pertussis control strategies and the options for improving current vaccines백일해: 백일해 통제 전략 및 현재 백신 개선을 위한 옵션journal-article Published on 2014-09-012024-08-01 Journal: Expert review of vaccines [Category] 백일해, [키워드] adjuvant pertactin pertussis Pertussis toxin Th1 [DOI] 10.1586/14760584.2014.944166 [Article Type] journal-article
Primary vaccination with the LiESP/QA-21 vaccine (CaniLeish) produces a cell-mediated immune response which is still present 1 year laterArticle Published on 2014-04-152023-06-02 Journal: Veterinary Immunology and Immunopathology [Category] 조류인플루엔자, [키워드] Canine leishmaniasis Cell-mediated immunity nitric oxide prevention Th1 vaccination [DOI] 10.1016/j.vetimm.2014.01.011
Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response인간의 면역 반응이 Plasmodium falciparum 감염에 대한 것: 이상적이고 효과적인 전통적인 TH1 면역 반응에 비해 THαβ 및 TH17 편향의 하위 최적성에 대한 분자적 증거Research Published on 2013-11-052024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] immune response malaria Th1 Th17 Th2 THαβ [DOI] 10.1186/1475-2875-12-392 PMC 바로가기 [Article Type] Research
CD4 + T-cell subsets in intestinal inflammationArticle Published on 2013-03-132023-08-30 Journal: Immunological reviews [Category] E형 간염, [키워드] intestinal inflammation T-cell differentiation Th1 Th17 Treg [DOI] 10.1111/imr.12039 PMC 바로가기
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophilsResearch Published on 2012-05-292022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] affecting Autoimmune blockade CD4 CD4+ T cells Central nervous system clinical consequence CNS compared complex coronavirus cytokine Demyelination detrimental disease downstream effector molecule Encephalomyelitis expression Factor feedback loops GM-CSF IFN-γ IFN-γ IL-17 independent Infected inflammatory condition inflammatory disease Interaction mechanism memory mice morbidity Mortality murine Neurotropic coronavirus neutrophil neutrophil infiltration Neutrophils not express pathogenic positive PROTECT provided recipient reduced reducing relative contribution rescued response Result survival T cell T cells Th1 Th17 Th17 cell tissue damage Transcription transcriptional regulation transfer upregulation virus was used wild-type [DOI] 10.1186/1742-2094-9-104 PMC 바로가기 [Article Type] Research
The Adjuvanticity of an O. volvulus -Derived r Ov -ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human PrimatesResearch Article Published on 2012-05-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Activation adjuvant adjuvanticity administration anti-RBD antibody Antibody Response antigens bystander Course DC different Effectiveness Efficacy element first vaccination functional host response IFN-γ IgG2a IL-2 IL-6 immunized induce Influenza virus maturation mice naïve NHPs non-human primate not affect Onchocerca volvulus primate promote promoted Protective protective immune response Protein provided RBD reported retained SARS-CoV spike protein sera subsequent Th1 Th1 cytokines Th2 response the receptor-binding domain titre TNF-α upregulated utility vaccination Vaccine vaccine antigen virus strains was used [DOI] 10.1371/journal.pone.0037019 PMC 바로가기 [Article Type] Research Article