Design and various in silico studies of the novel curcumin derivatives as potential candidates against COVID-19 -associated main enzymesCOVID-19 관련 주요 효소에 대한 잠재적 후보로서 새로운 커큐민 유도체의 설계 및 다양한 in silico 연구Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro acute respiratory syndrome ADME Analysis Anti-inflammatory antioxidant Antiviral antiviral drug antiviral drugs Area binding binding score candidate caused Combination contagious contagious disease coronavirus coronavirus disease Coronaviruses COVID-19 Curcumin derivative disease docking drug drug design drugs Effectiveness enzyme Enzymes expected in silico inhibitor inhibitors Ligand MD simulation MD simulations Mechanics MM-PBSA molecular molecular docking studies Molecular dynamic Molecular mechanics Novel coronavirus novel coronavirus disease Nsp15 Nsp7 patients performed pharmacokinetic PLPro Protein protein complex residue Safe SARS-CoV-2 SARS-CoV-2 virus Severe acute respiratory syndrome shown Simulation spike surface surface area the SARS-CoV-2 virus therapeutic Toxicity was determined [DOI] 10.1016/j.compbiolchem.2022.107657 PMC 바로가기 [Article Type] Article
Lysozyme Protects Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Inflammation in Human Corneal Epithelial Cells리소자임은 인간 각막 상피 세포의 중증 급성 호흡기 증후군 코로나바이러스 2 감염 및 염증으로부터 보호합니다Article Published on 2022-06-012022-09-11 Journal: Investigative ophthalmology & visual science [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Against analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cell entry Cell toxicity characterized Corneal coronavirus coronavirus 2 Effect entry of SARS-CoV-2 enzyme epithelial cell epithelial cells expressed expression Human IL-6 Infection Inflammatory cytokine Inflammatory response luciferase lysozyme MCP-1 Pathogens pro-inflammatory molecule pro-inflammatory molecules proinflammatory molecule proinflammatory molecules PROTECT protective effect Protective effects pseudotyped respiratory robust RT-PCR SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection secretion Serine Spike protein Spike proteins stimulated suggested susceptibility tears TMPRSS2 TNF-α Toxicity transmembrane serine protease was measured was tested western blotting [DOI] 10.1167/iovs.63.6.16 PMC 바로가기 [Article Type] Article
Contrasting tourism regimes due to the COVID-19 lockdown reveal varied genomic toxicity in a tropical beach in the Southern AtlanticCOVID-19 잠금으로 인한 대조적인 관광 체제는 남대서양의 열대 해변에서 다양한 게놈 독성을 나타냅니다Article Published on 2022-05-312022-09-11 Journal: Environmental Monitoring and Assessment [Category] 유전자 메커니즘, [키워드] absence Abudefduf Analysis analyzed Beaches blood sample Blood samples Brazil change collected control group COVID-19 COVID-19 pandemic demonstrated ecosystem Effect Environmental impact environmental monitoring Frequency Galinha Galinhas genomic genotoxic genotoxicity greater highest incidence lack lockdown micronucleus Migration Morphological NMA nuclear Porto species stability suffered Tourism Tourism impact. Toxicity tropical [DOI] 10.1007/s10661-022-10112-w PMC 바로가기 [Article Type] Article
Ultra-Hypofractionated vs. Moderate Fractionated Whole Breast Three Dimensional Conformal Radiotherapy during the COVID-19 PandemicRandomized Controlled Trial Published on 2022-05-302022-10-05 Journal: Medicina [Category] COVID19(2023년), SARS, 임상, [키워드] addition analyzed application Breast Breast cancer breast cancer patient breast cancer patients comparable Compliance cosmetic COVID COVID-19 COVID-19 outbreak COVID-19 pandemic CTCAE descending dose fraction Grade 1 infected case ipsilateral lung material median moderate objective outbreak pandemic parameters Patient patients with moderate Prevalence Radiation Radiation dose Radiotherapy randomized study reducing regimen risk SARS-CoV-2 Scoring significantly lower Still tissue Toxicity Treatment ultra-hypofractionated radiotherapy. [DOI] 10.3390/medicina58060745 PMC 바로가기 [Article Type] Randomized Controlled Trial
Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot studyClinical Trial Published on 2022-05-262022-10-04 Journal: Stem Cell Research & Therapy [Category] 임상, [키워드] adipose administration adverse event adverse events assigned chest imaging Clinical characteristics clinical study COVID-19 COVID-19 patient COVID-19 patients D-dimer daily dose demographic data dose Efficacy Efficiency enrolled event Evidence Exosome Exosomes Extracellular vesicles feasible females Hospital admission IL-6 incidence inhalation interquartile range IQR laboratory result Lymphocyte count male median median age median time Mesenchymal stromal cell. MSC nebulized onset of symptom Patient patients patients with COVID-19 pilot study Pneumonia Primary outcome pulmonary lesion receive safety profile Serious Adverse Events serum Seven severe COVID-19 single-arm slight increase stromal cell supported tested tissue Toxicity Treatment Trial Vesicle vesicles Wuhan, China [DOI] 10.1186/s13287-022-02900-5 PMC 바로가기 [Article Type] Clinical Trial
Immunization with SARS-CoV-2 Nucleocapsid protein triggers a pulmonary immune response in ratsSARS-CoV-2 뉴클레오캡시드 단백질을 사용한 면역은 쥐에서 폐 면역 반응을 유발합니다Article Published on 2022-05-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] absence Activation administration affecting alteration animals anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody Asymptomatic biochemical can be used Clinical studies clinical study clinical symptom Clinical symptoms COVID-19 COVID-19 severity dead elicit emerging viruses Exacerbation groups histological histological analysis IgG antibodies immune response immunization immunological effect induce injection lead Local lung Microthrombosis multiple organ failure once a week Organ failure parameters produced Protein pulmonary immune response RATs Rattus Recombinant nucleocapsid protein recombinant proteins required Research respiratory insufficiency Safe SARS-CoV-2 SARS-CoV-2 pandemic sensitization Side effects Spread strain submitted Support synthesis Toxicity Trigger triggered vaccination Vaccine virus viruses world population [DOI] 10.1371/journal.pone.0268434 PMC 바로가기 [Article Type] Article
Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor팔미토일에탄올아미드(PEA)는 S 단백질 및 ACE-2 수용체와 상호작용하여 SARS-CoV-2 진입을 억제합니다Article Published on 2022-05-172022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 activate activated adjuvant therapy Antiviral antiviral agent antiviral drug antiviral drugs antiviral potency binding bioactive lipids cascade cause cellular clinical test Clinical tests clinical trial connection Coronaviruses counteract Course COVID-19 COVID-19 pandemic Degradation derangement Disruption drop droplets energy entry receptor event Evidence fatty Fatty acid generate glycoprotein Glycoproteins highlight Huh-7 cells humans in viral Infection Inflammation inflammatory stimuli lack life cycle Lipid lipid droplets lipid metabolism lipids mechanism of action mechanisms membrane metabolism nutraceutical palmitoylethanolamide Pathways PEA Prevent protective effect Protective effects recent replicate Replication Research RNA virus S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein second significantly Spike protein the SARS-CoV-2 therapy Toxicity transcription factor Treatment Usage viral infection viral life cycle virus viruses VSV [DOI] 10.3390/v14051080 PMC 바로가기 [Article Type] Article
Generation of environmental persistent free radicals (EPFRs) enhances ecotoxicological effects of the disposable face mask waste with the COVID-19 pandemic환경 지속성 자유 라디칼(EPFR)의 생성은 COVID-19 전염병으로 일회용 안면 마스크 폐기물의 생태독성 효과를 향상시킵니다Article Published on 2022-05-152022-09-11 Journal: Environmental pollution (Barking, Essex : 1987) [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetophenone acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BENZOTHIAZOLE bisphenol butylphenol carbon characteristic contribute coronavirus COVID-19 COVID-19 pandemic cytotoxicity dominant dramatic increase Effect ENhance Environmentally persistent free radicals (EPFRs) exposure to Face mask free radical generate Generation Health risk Heavy metals higher risk highlight in vitro Leachate Mask microplastics Microplastics (MPs) mixture N95 respirator N95 respirators oxidative stress oxygen pandemic phthalide plastic Plastic face masks (DPFs). plasticizer Polypropylene produced risk Risk assessment SARS-CoV-2 severe acute respiratory syndrome Coronavirus solvent surgical TERT tested toxic effects Toxicity water [DOI] 10.1016/j.envpol.2022.119019 PMC 바로가기 [Article Type] Article
Pharmacokinetics and safety of inhaled ivermectin in mice as a potential COVID-19 treatment잠재적인 COVID-19 치료제로서 생쥐에서 흡입된 이버멕틴의 약동학 및 안전성Article Published on 2022-05-102022-09-11 Journal: International journal of pharmaceutics [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] administration analyzed Antiviral antiviral efficacy BALB/c mice BALF binding Bronchoalveolar lavage fluid clinically collected Concentration concentrations COVID-19 Critical drug Dry Dry powder aerosol Formulation healthy histological in vitro in vitro experiment Inhalable ivermectin inhalation Inhaled intratracheal administration investigated Ivermectin kidney Lactose less limit limitation liver Local low dose lung Lungs mice Mild overcome pharmacokinetic pharmacokinetics plasma Protein Protein binding resolved respiratory tract Safety SARS-CoV-2 spleen spray Spray drying therapeutic Toxicity Treatment viral pathology was used [DOI] 10.1016/j.ijpharm.2022.121688 PMC 바로가기 [Article Type] Article
Detoxifying SARS-CoV-2 antiviral drugs from model and real wastewaters by industrial waste-derived multiphase photocatalysts산업폐기물 유래 다상 광촉매로 모델 폐수 및 실제 폐수에서 SARS-CoV-2 항바이러스제 해독Article Published on 2022-05-052022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 치료제, [키워드] Ammonium antiviral drug antiviral drugs applied Combination Concentration contrary COVID-19 pandemic Danio Degradation degrade Effect effective Efficiency Embryo highest hydrophilic Industrial Industrial waste Lopinavir LOPINAVIR AND RITONAVIR Multiphase photocatalyst Photocatalysis plant reported resulting Ritonavir SARS-CoV-2 temperature tested Toxicity treated Treatment visible light wastewater water Water pollution Water purification Water purification. X-ray diffraction zebrafish [DOI] 10.1016/j.jhazmat.2022.128300 PMC 바로가기 [Article Type] Article