traits – Page 12 – Communicable Diseases Research

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다

Research Article

Published on 2017-03-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Systems Level Analyses Reveal Multiple Regulatory Activities of CodY Controlling Metabolism, Motility and Virulence in Listeria monocytogenes

시스템 수준 분석을 통해 Listeria monocytogenes에서 대사, 운동성 및 독성을 제어하는 CodY의 여러 조절 활동이 밝혀졌습니다.

Research Article

Published on 2016-02-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] actA activate activator activity adaptation Affect Amino acid amino acids Analysis Bacteria bacterial pathogen Bacterial pathogens BCAA bind binding branch CodY condition conditions controlling dependent on DNA DNA binding environmental cues expression facilitate function functions Gene Expression Genes Genome gram Gram-positive bacteria growth Host identify identifying L . monocytogene Level Ligand ligands Listeria Listeria monocytogene Listeria monocytogenes mammalian metabolic genes metabolism modulate motility Multiple multiple pathway multiple pathways observation pathogen Pathogens pathway Pathways performed previous study prfA raised regulated regulator gene Regulatory regulatory network reported repress repressor respond response responses Sequencing Stress stress responses System Target genes thought traits Transcription transcription factor transcription factors virulence virulence gene virulence genes
[DOI] 10.1371/journal.pgen.1005870 PMC 바로가기 [Article Type] Research Article

Bovine Host Genetic Variation Influences Rumen Microbial Methane Production with Best Selection Criterion for Low Methane Emitting and Efficiently Feed Converting Hosts Based on Metagenomic Gene Abundance

소 숙주 유전자 변이는 메타게놈 유전자 풍부도를 기반으로 하는 낮은 메탄 방출 및 효율적인 사료 전환 숙주에 대한 최상의 선택 기준으로 반추위 미생물 메탄 생산에 영향을 미칩니다.

Research Article

Published on 2016-02-182022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] abundance analysed Analysis animals anthropogenic anthropogenic activities archaeal can be used cattle contribute Control criterion cross talk crossbred diet Effect effective experiment explained feed conversion efficiency fmdB FucI functional gene gastrointestinal tract Genes Genetic genetic analysis genetic control genetic influence genetic link genetic link controlling genetic selection genetics greenhouse gas greenhouse gas emissions group Health Host hosts idea implementation influence mcrA metabolism metagenome metagenomic metagenomic profiling Methane methane emission methane emissions Methanogenesis methanogenic archaea microbial Microbiome microbiota nutrition open predict principle produced Production progeny proof provide provided ranking respiration chambers Rumen ruminal ruminal digesta ruminant ruminants Selection shown significantly species suggested traits TSTA3 Variation
[DOI] 10.1371/journal.pgen.1005846 PMC 바로가기 [Article Type] Research Article

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

Research Article

Published on 2015-10-092022-10-28
Journal: PLoS Genetics [Category] Coronavirus,

[키워드] Animal host animal model approach assist candidate gene chromosome classical complex contribute contributing to disease disease severity E3 ubiquitin ligase evaluate fiber Genes Genetic genetic data Genetic variation genetics genome region Health highly pathogenic Host host gene identification identify Inflammation Inflammatory response knockout mice loci locus Lung pathology mice microbial mouse model New Noncoding RNAs outcome outcomes pathogen Pathogenesis Pathogens pathology phenotype phenotypic platform populations regulate resource respiratory viruses responses SARS patient SARS-CoV SARS-CoV infection single gene Spread statistical susceptibility loci the disease traits transcriptomic data utility Vascular viral titer virus replication viruses weight loss were used
[DOI] 10.1371/journal.pgen.1005504 PMC 바로가기 [Article Type] Research Article

Heterologous Aggregates Promote De Novo Prion Appearance via More than One Mechanism

이종 골재는 하나 이상의 메커니즘을 통해 De Novo Prion 모양을 촉진합니다.

Research Article

Published on 2015-01-082022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Phenotype Ontologies and Cross-Species Analysis for Translational Research

번역 연구를 위한 표현형 온톨로지 및 교차 종 분석

Review

Published on 2014-04-032022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Classic Selective Sweeps Revealed by Massive Sequencing in Cattle

소에서 대규모 시퀀싱으로 밝혀진 클래식 선택적 스윕

Research Article

Published on 2014-02-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a major affected affecting allele among others Analysis ancestors applied approach association autosomal SNP candidate gene cattle classic CLR complementary complexity Composite current detect detectable disequilibrium Domestication ERBB4 Evidence faster fixation Fleckvieh followed by Genetic genetics Genome genome-wide association genomic genomic region help homozygosity Human identify iHS IMPROVE KIT life style likelihood ratio linkage Linkage disequilibrium massive MC1R MITF multiple statistical metrics NRG4 overlap Perspective phenotype Phenotypes physical Protein QTL mapping QTLs Ratio re-sequencing Region regions Result Revealed score sensory perception Sequencing sequencing technology significantly somatic cell somatic cell count speciation subsequent TAS2R16 temper thought TMEM132D traits utility whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1004148 PMC 바로가기 [Article Type] Research Article

Arabidopsis thaliana RESISTANCE TO FUSARIUM OXYSPORUM 2 Implicates Tyrosine-Sulfated Peptide Signaling in Susceptibility and Resistance to Root Infection

Arabidopsis thaliana FUSARIUM OXYSPORUM 2에 대한 내성은 뿌리 감염에 대한 감수성과 내성에 티로신-황산염 신호 전달을 의미합니다

Research Article

Published on 2013-05-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다

Research Article

Published on 2013-05-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated After allele Analysis approved drug Arthritis association Author B cells B lymphocyte B lymphocytes Biology can be used CD19+ CD40 CD40 ligand CD40 signaling Cell cell line chemical compounds clinical care coding Combination complex Compound consequence controls correlation counter deep sequencing develop disease drug Drug discovery drugs effort eQTL ExoN exonic explain expression finding Follow-up gain-of-function Genetic genetic findings Genome-wide association studies Genome-wide association study genotyping guide GWAS healthy control homozygous Human Human genetics identify implicated increase individuals Infection Inflammation inhibit inhibitor loci locus lymphocyte Lymphocytes mononuclear cell mononuclear cells mouse NF-kB NF-κB NF-κB signaling non-risk allele observé p65 pathway Patient Peripheral blood Peripheral blood mononuclear cells Phosphorylation Protein Quantitative RA RELA reporter retroviral Rheumatoid rheumatoid arthritis risk risk allele Screen second Sequencing seropositive Signaling single SNP small molecule Small molecules small-molecule screen subject subunit therapy trait traits transcription factor treat variant while
[DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article

Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

공통 변이체는 매우 작은 개체를 제외하고 분포 꼬리의 키에 대한 예측된 다유전자 효과를 보여줍니다

Research Article

Published on 2011-12-292022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a major allele Author average calculated chance classic cohorts common common disease common variants complex decrease determine discrepancy distribution Effect effect size Effects effort expectation expected explain explained extreme Factor found fraction Frequency Genetic Genetic variant Genetic variation Height Human genome implication include individual individuals less loci low frequency Odds ratio Odds ratios phenotype Phenotypes population-based cohort Predictive quantitative traits short stature show shown significantly stature tail trait traits variant variants Variation whole-exome sequencing whole-genome
[DOI] 10.1371/journal.pgen.1002439 PMC 바로가기 [Article Type] Research Article