transcriptomic – Page 12 – Communicable Diseases Research

Identifying COVID-19-Specific Transcriptomic Biomarkers with Machine Learning Methods

Research Article

Published on 2021-07-062022-10-27
Journal: BioMed Research International [Category] COVID-19, MERS, SARS,

SARS-CoV-2 infection in the mouse olfactory system

Article

Published on 2021-07-062022-10-04
Journal: Cell Discovery [Category] 진단,

Identifying COVID-19-Specific Transcriptomic Biomarkers with Machine Learning Methods

기계 학습 방법을 갖는 Covid-19- 특이 적 전 사체 바이오 마커 식별

Research Article

Published on 2021-07-062022-09-10
Journal: BioMed Research International [Category] 바이오마커, 유전자 메커니즘, 진단,

[키워드] Accuracy analysed Analysis applied asymptomatic patients Bacterial infection Biomarker Biomarkers build candidate gene caused classification algorithm classification algorithms Classifier Clinical use coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 diagnosis COVID-19 infection dataset Diagnosis diagnosis of COVID-19 Diseases Efficacy extension healthy control healthy controls Host identify identifying IMPROVE infected with SARS-CoV-2 Infection Infectious diseases Influenza initial machine learning machine learning model other respiratory infections pathogenic Patient presymptomatic previous study released required respiratory Respiratory disease respiratory infections respiratory infectious disease resulting severe respiratory disease Spread susceptible susceptible people Symptom Symptoms transcriptomic virus with COVID-19
[DOI] 10.1155/2021/9939134 PMC 바로가기 [Article Type] Research Article

Babaodan controls excessive immune responses and may represent a cytokine-targeted agent suitable for COVID-19 treatment

Babaodan은 과도한 면역 반응을 제어하고 COVID-19 치료에 적합한 사이토카인 표적 제제를 나타낼 수 있습니다

Article

Published on 2021-07-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 유전자 메커니즘, 치료법,

[키워드] Activation adapter anti-cytokine storm anti-inflammatory activity approach Babaodan Bacterial Bacterial infection cellular Chinese contribute Control COVID-19 COVID-19 patient COVID-19 patients Cytokine storm Cytokines demonstrated determine evaluated excessive immune response IL-6 immune responses immunomodulatory in vivo increased survival indicated Inflammation inhibited Macrophage macrophages MAPK MAPK signaling mechanism mice molecular mouse model MYD88 NF-κB occur Occurrence overproduction Pathways Pneumonia pro-inflammatory cytokine pro-inflammatory cytokines protective role Protein recruitment reduction in responsible resulting reveal robust SARS-COV-2 infection Seven severe COVID-19 severely ill COVID-19 patients significantly TCM therapy TLR TLR2 TLR3 TLRs Traditional Chinese medicine transcriptomic treating COVID-19 Treatment TRIF viruses was used
[DOI] 10.1016/j.biopha.2021.111586 PMC 바로가기 [Article Type] Article

Angiotensin-converting enzyme 2 gene expression in human male urological tissues: implications for pathogenesis and virus transmission pathways

Original Research

Published on 2021-07-012022-10-27
Journal: African Journal of Urology [Category] COVID-19,

[키워드] ACE2 ACE2 gene acute respiratory syndrome angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor binding bladder caused change comparable coronavirus COVID-19 database dataset demonstrated enzyme Express expression Fertility functions Gene Expression gene expression profile genital Genitalia host cell membrane human kidney human lung tissue implication Infection Interaction kidneys Lungs male occur organ Pathogenesis pathological pathway Prostate receptor reproductive Result SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 susceptible tissue transcriptomic Urology viral spike protein virus transmission
[DOI] 10.1186/s12301-021-00192-4 PMC 바로가기 [Article Type] Original Research

50-gene risk profiles in peripheral blood predict COVID-19 outcomes: A retrospective, multicenter cohort study

말초 혈액의 50개 유전자 위험 프로필이 COVID-19 결과를 예측합니다: 후향적, 다기관 코호트 연구

Multicenter Study

Published on 2021-07-012022-09-11
Journal: EBioMedicine [Category] MERS, 바이오마커, 유전자 메커니즘,

[키워드] 50-gene risk profiles Action Adaptive immune response analyzed applied B cells Blood CD4 CD8 Cell cellular change Chicago Cohort cohorts college COVID-19 Cutoff dendritic cells Dendritic Cells and Neutrophils Diseases expressing Features fibrosis foundation Gene Expression heart ICU ICU admission identify idiopathic Idiopathic pulmonary fibrosis IgG immune immune responses in-hospital mortality intensive care intensive care unit Interstitial lung disease investigated IPF London Lung disease Lymphocytes mechanical ventilation Mild Monocytes Mortality multicenter cohort study Neutrophils NHLBI outcomes overlap Peripheral blood plasmablasts predict predicted Predictive producing profile profiles pulmonary pulmonary fibrosis retrospective risk RNA-sequencing scientist Scoring South supported T cells T lymphocytes transcript level transcriptomic university validation was used were used
[DOI] 10.1016/j.ebiom.2021.103439 PMC 바로가기 [Article Type] Multicenter Study

Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection

SARS-CoV-2 바이러스 감염 중 자가항원 발현 향상

Immunology

Published on 2021-06-302022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Activation Analysis Asymptomatic COVID-19 autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity Autopsy bioinformatics Blood conducted confirmed case confirmed cases COVID-19 COVID-19 infections datasets determine Effect enhanced evaluate expression level expression levels follow-up studies follow-up study homeostasis IFIH1 Immune homeostasis immunopathology in-silico Infection infections lead longitudinal low-density lung lung autopsies mononuclear cell mononuclear cells MPO neutrophil neutrophil activation overexpressed PADI4 PBMCs Peripheral blood Peripheral blood mononuclear cells plasma protein protein level protein levels PRTN3 PTPRN2 respiratory viral infection SAR-CoV-2 SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 infections severity of COVID-19 significantly single-cell dataset subset tissue Tolerance transcriptomic TRIM21 TSHR upregulated upregulation Viral viral infection viral infections Whole blood
[DOI] 10.3389/fimmu.2021.686462 PMC 바로가기 [Article Type] Immunology

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

Immunology

Published on 2021-06-252022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] 48 hour ACE2 ANPEP Apoptosis Autoimmune disease cancers cardiovascular comorbidity cardiovascular disease CEACAM1 cell death changes in complexes contribute controls coronavirus Coronavirus infection Coronaviruses COVID-19 CSF1 CSF3 CVD Cytokine storms DAMP DAMPs dataset death DPP4 Endothelial cell enzyme Epigenetic ER stress examined Express expressed expression facilitate Factor Ferroptosis hours post-infection Human hyperlipidemia IL6 Immunity Inflammation innate immune innate immune responses LPS majority marker MERS-CoV Microarray mitochondrial mitotic modulated monocyte Myelopoiesis Nrf2 nucleic acid oxidative phosphorylation PAMP Proinflammatory cytokine Proinflammatory response protein complex pyroptosis receptor regulate ROS stimulated Stimulation storm Stress subsequent Thromboembolism thrombosis TMPRSS2 TNFα trained immunity transcriptomic upregulated upregulation Viremia virus entry
[DOI] 10.3389/fimmu.2021.653110 PMC 바로가기 [Article Type] Immunology

AI-guided discovery of the invariant host response to viral pandemics

바이러스 전염병에 대한 불변 숙주 반응의 AI 유도 발견

Research Paper

Published on 2021-06-112022-09-11
Journal: EBioMedicine [Category] MERS, 바이오마커, 진단, 치료제,

[키워드] “cytokine storm” abrogate ACE2 acting analyzed Angiotensin converting enzyme (ACE)-2 Antiviral antiviral agent Apoptosis approach Artificial intelligence/machine learning Boolean equivalent clusters candidate drugs cause cell senescence center clinical conserved Cooperative Coronavirus COVID-19 coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dataset determine Diego disease severity EIDD-2801 elevated ENCODE entry of SARS-CoV-2 epithelial facilitate fatal COVID-19 fatal disease fatality finding Fund funding hamster Healthcare system High-dose host cells Host immune response host response Human IL15 IL15RA immune response immunologist implicated in viral Interleukin 15 (IL15) knowledge limit limits LJI lung Lung alveoli lung epithelial Lungs myeloid cell myeloid cells natural killer (NK) cells Neutralizing antibodies neutralizing antibody NIH NK cell office over Pandemics paradoxical Patient plasma Plasma levels President Program Quantitative receptor scientist signature STEM stem cell subset supported System therapeutic to define transcriptomic University of California utility Viral virus was used
[DOI] 10.1016/j.ebiom.2021.103390 PMC 바로가기 [Article Type] Research Paper

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

네트워크 의학은 SARS-COV-2/COVID-19 감염을 뇌 미세 혈관 손상 및 치매 유사인지 장애에서 신경 염증에 연결합니다.

Research

Published on 2021-06-092022-09-10
Journal: Alzheimer's Research & Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료기술,

[키워드] addition Alzheimer’s disease Alzheimer’s disease Analysis Antiviral ApoE Biomarker Blood Brain Brain microvasculature brains BSG causal relationship cell types cerebrospinal fluid change Cognitive impairment complications conducted COVID-19 CRISPR CRISPR-Cas9 Defense Dementia elevated Endothelial cell endothelial cells expression expression of SARS-CoV-2 Factor furin Genetic Guidance healthy control healthy controls help Host Human brain IFITM2 IFITM3 IFNAR1 implicated IMPROVE increasingly individual individuals infected with COVID-19 infected with SARS-CoV-2 Infection investigated lead low expression LY6E marker gene Measures mechanism microvascular injury network network medicine Neuroinflammation neurologic neurological manifestation neurological manifestations Neuron neurons overlap pathway Patient patients with COVID-19 Prevalence protein-protein interaction reduced reported responsible Result risk allele RNA-sequencing SARS-CoV-2 SARS-CoV-2 entry factor SARS-CoV-2 entry factors SARS-COV-2 infection Single-cell/nucleus supplementary material the SARS-CoV-2 transcriptomic Transcriptomic analyses transcriptomic profile transcriptomic profiles treatment interventions while
[DOI] 10.1186/s13195-021-00850-3 PMC 바로가기 [Article Type] Research