Enrichment analysis on regulatory subspaces: A novel direction for the superior description of cellular responses to SARS-CoV-2규제 부분 공간에 대한 농축 분석: SARS-CoV-2에 대한 세포 반응의 우수한 설명을 위한 새로운 방향Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신종인플루엔자, [키워드] affected Algorithm Analysis applied Biclustering Cell cell line cellular response Characteristics classic Clustering Comparative analysis complex Computational biology Coverage COVID-19 database Discriminative regulatory patterns enrichment enrichment analysis False positive functional enrichment Functional enrichment analysis GO term GO terms H1N1 IAV identify Impact IMPROVE in vivo infected cell infected cells Interaction KEGG pathway knowledge knowledge extraction lack lung cell line lung cell lines machine machine learning machine learning algorithm machine learning approach motivation observations pathophysiological performed Predictive Regulatory RSV SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus scarcity significantly the SARS-CoV-2 virus transcriptional response transcriptomic data transcriptomics variant virus viruses [DOI] 10.1016/j.compbiomed.2022.105443 PMC 바로가기 [Article Type] Article
Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects짧은 이중 가닥, 평활 말단 RNA의 서열 특이적 특징은 RIG-I 및 유형 1 인터페론 의존성 또는 독립적 항바이러스 효과를 갖는다Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] adaptors Adenovirus Anti-viral anti-viral effect Antiviral Antiviral agents Antiviral effect antiviral effects assays Cell cell cycle cell cycle genes cell line cells cellular complementary cytoplasmic DNA DNA virus downregulated dsRNA dsRNAs Effect elicited fibroblast Gene Expression H3N2 human airway IFN IFN-alpha IFN-I IFNAR2 independent independent of indicated Infection Influenza influenza A influenza A virus Influenza virus interferon knock-out library MDA5 mechanism mimicking molecular patterns MYD88 organism Organisms pathogen pathogen-associated molecular patterns Pathogens Randomized receptor required retinoic acid retinoic acid-inducible gene I RIG-I RNA RNA therapy RNA virus RNAs SARS-CoV-2 sequence short double-strand blunt-end RNA. transcriptomics transfection Type ZNFX1 [DOI] 10.3390/v14071407 PMC 바로가기 [Article Type] Article
Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data Protocols Published on 2022-06-172022-10-05 Journal: Nature protocols [Category] 유전자 메커니즘, [키워드] bioinformatics Community Complete complex covariate adjustment Critical exploratory functional help High-resolution Interpretation Liquid chromatography MetaboAnalyst metabolomics Metadata Nature overcome parameter platform protocol Stage statistical analysis transcriptomics [DOI] 10.1038/s41596-022-00710-w [Article Type] Protocols
Transcriptome Analysis of Plasmodium falciparum Isolates From Benin Reveals Specific Gene Expression Associated With Cerebral MalariaArticle Published on 2022-06-152024-08-28 Journal: Nanoscale [Category] 말라리아, [키워드] cerebral malaria cytoadherence Plasmodium falciparum transcriptomics var genes
Interpreting the B-cell receptor repertoire with single-cell gene expression using Benisse Research Published on 2022-06-022022-10-05 Journal: The Pan African Medical Journal [Category] 변종, 유전자 메커니즘, [키워드] Activation Analysis antibodies Antigen approach association B cell B cells B-cell BCR correlation COVID-19 infections digestion Efficiency Evolution form function functional Gene Expression generate highest Interpretation Interpreting invading pathogens investigated linear neutralization receptor scRNA-seq scRNA-seq dataset secreted sequence Sequencing single-cell Single-cell RNA-sequencing T-Cell Receptors Trajectories transcriptomics yielding [DOI] 10.1038/s42256-022-00492-6 [Article Type] Research
When Mosquito HV bites Biomark HD: An automated workflow for high-throughput qPCRArticle Published on 2022-06-012023-07-07 Journal: Slas Technology [Category] COVID19(2023년), [키워드] Automation Core Facility Fluidigm High-throughput Mosquito HV RNA transcriptomics [DOI] 10.1016/j.slast.2021.12.007
Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosisCaspase-4/11은 염증 및 면역 혈전증을 촉진하여 SARS-CoV-2 감염의 질병 중증도를 악화시킵니다.Article Published on 2022-05-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accumulated acute respiratory syndrome Blood CASP4 caspase caspase-11 Coagulopathy coronavirus CXCL1 detrimental disease severity downstream drug target effective endothelial damage exacerbate expressed expression Factor functions gene signature GSDMD Health homolog humans IL-6 immunothrombosis Infection Inflammation Inflammatory inflammatory mediator Innate immunity less lung Lung pathology Lungs maintain marker mice molecular target neutrophil new treatment strategy pathway promote protein level reduced SARS-COV-2 infection SARS–CoV-2 severe COVID-19 severity targeting therapeutic thrombosis transcription factor transcriptomics Treatment up-regulated Vascular vessel viral titer von Willebrand factor weight loss wild-type [DOI] 10.1073/pnas.2202012119 PMC 바로가기 [Article Type] Article
Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study고형 종양의 영향을 받는 환자에서 발열성 COVID-19의 발병률 및 면역학적 특징: 전향적 코호트 연구Article Published on 2022-05-142022-09-11 Journal: Journal of Translational Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected Asymptomatic case Asymptomatic cases Asymptomatic COVID-19 asymptomatic infection asymptomatic patient asymptomatic patients baseline Cancer Cancer center changes in chemokine collected COVID-19 COVID-19 in patient COVID-19 pandemic downregulation evaluated feature First wave General population IgM Immunoglobulin interleukin 6 Italy KEGG mononuclear cell mononuclear cells Nasopharyngeal swab NPs p-values pathway Pathways Patient patients PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells positive prospective cohort study rationale receptor recruited RNA SARS-CoV-2 SARS-CoV-2 IgM Sequencing Seroconversion seroconversion rate serology Signaling solid cancer subset T-cell receptor tested Transcriptome transcriptome sequencing transcriptomic analysis transcriptomics treated upregulated Viral Viral RNA was performed [DOI] 10.1186/s12967-022-03429-0 PMC 바로가기 [Article Type] Article
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomicsCOVID-19 햄스터 모델에서 덱사메타손 및 항체 치료의 주요 이점, 단일 세포 전사체로 밝혀짐Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed Anti-inflammatory anti-inflammatory effect anti-inflammatory properties anti-inflammatory property anti-SARS-CoV-2 antibody Anti-viral anti-viral effect anti-viral effects antibodies antibody antibody treatment benefit Cell combination therapy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Dexamethasone disease drugs Effect effective Efficacy exhibited hamster host responses immune responses Immunity Infection Inflammatory inflammatory cell lung Lungs mechanisms monoclonal antibody monoclonal antibody therapy Neutrophils potential mechanism prevented pulmonary pulmonary immune response recruitment respiratory SARS-CoV-2 scRNA-seq severe disease single-cell Standard-of-care subpopulation synergistic synergistic effects therapeutic option therapeutic options Therapies therapy transcriptomic transcriptomics Treatment Vaccine vaccine efficacy Vaccine hesitancy variants Viral viral burden was reduced [DOI] 10.1016/j.ymthe.2022.03.014 PMC 바로가기 [Article Type] Article
The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic대유행 뇌: COVID-19 대유행 동안 감염되지 않은 개인의 신경염Article Published on 2022-05-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] Activation aligned Brain Brain imaging change Combination control subject control subjects COVID-19 pandemic COVID-19 research dataset demonstrated Depression dysregulation Effect elevated enrolled examined explosion expression fatigue functions Future Health healthy individuals hippocampus increase in independent individual Inflammatory marker inflammatory markers interleukin interleukin-16 intraparietal sulcus involved kDa Magnetic resonance spectroscopy marker measure mechanism Mental mental fatigue mental health molecular monocyte monocyte chemoattractant protein-1 MRS multiple comparisons myoinositol negative test Neuroimaging Neuroinflammation non-infected pandemic pet physical positron emission Positron emission tomography precuneus preliminary findings Prevalence Protein Research SARS-CoV-2 antibodies serum Serum level serum levels several gene several genes statistical significance Stress Stressor subjects Symptom symptom burden Symptoms tomography transcriptomics TSPO uninfected virus while [DOI] 10.1016/j.bbi.2022.02.018 PMC 바로가기 [Article Type] Article