upstream – Page 12 – Communicable Diseases Research

Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway

Cek1 경로의 활성화에 의해 칸디다 알비칸스 β(1,3)-글루칸의 노출이 촉진됩니다

Research Article

Published on 2019-01-312022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Reduced monocyte and macrophage TNFSF15 /TL1A expression is associated with susceptibility to inflammatory bowel disease

감소된 단핵구 및 대식세포 TNFSF15 /TL1A 발현은 염증성 장 질환에 대한 감수성과 관련이 있습니다

Research Article

Published on 2018-09-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation addition Affect allele animal model animal models association assumption bowel breakdown cell type cell types characterized chronic chronic inflammation compromise condition contribute Crohn’s disease cytokine decreased expression determine disease disease risk ENCODE ENhance Ethnic groups Evidence expression expression measurement functional genetic change genetic loci Genetic variant Genome-wide association studies Genotype Gut Haplotype healthy volunteer Hypothesis IBD IBD loci Immune homeostasis immunopathology increase Inflammation Inflammatory bowel disease intestinal list locus lymphocyte Macrophage macrophage differentiation macrophages mechanism monocyte Monocytes murine model murine models over patients Peripheral blood peripheral blood monocytes persist polymorphism Polymorphisms predisposition pro-inflammatory promote protective role protein level protein levels question receptor regulated regulatory region required responsible risk risk allele RNA shown Signaling Stimulation subtype susceptibility T cell T cells TNF TNFSF15 ulcerative colitis upstream variant variety
[DOI] 10.1371/journal.pgen.1007458 PMC 바로가기 [Article Type] Research Article

A novel mechanism of RNase L inhibition: Theiler’s virus L* protein prevents 2-5A from binding to RNase L

Research Article

Published on 2018-04-132022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

Controlled branched-chain amino acids auxotrophy in Listeria monocytogenes allows isoleucine to serve as a host signal and virulence effector

Listeria monocytogenes의 조절된 분지쇄 아미노산 영양요구성은 이소류신이 숙주 신호 및 독성 효과기 역할을 할 수 있도록 합니다.

Research Article

Published on 2018-03-122022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate adaptation amino acids Bacteria Bacterial pathogens BCAA BCAA biosynthesis BCAA biosynthesis genes branched-chain amino acid branched-chain amino acids CodY conditions Control Controlled deficiency dependent on downstream gene downstream genes Evidence expression function Gene regulation highlight Host Infection intracellular pathogen isoleucine L . monocytogene Listeria Listeria monocytogene Listeria monocytogenes mammalian cell mechanism metabolic pathway metabolic pathways metabolism metabolites occur pathogen pathogenic Pathogens regulate Regulation represse respond restrict Rli60 saprophyte switching transcribed transition Trigger triggers upregulated upstream virulence virulence gene virulence genes virulent while
[DOI] 10.1371/journal.pgen.1007283 PMC 바로가기 [Article Type] Research Article

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

HPV 통합은 높은 바이러스 종양 유전자 발현을 유도하는 바이러스 세포 슈퍼 인핸서를 생성하기 위해 세포 인핸서를 가로채고 다량체화합니다.

Research Article

Published on 2018-01-242022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accumulation amplification amplified BRD4 Cancer cancers cellular cellular DNA chromatin chromosome composed de novo dysregulated element enhancer Epigenetic example expressed expression generate genesis Genetic Genome genomic H3K27ac Host HPV human cancers human papillomavirus Infection integration intergenic region loci locus marker mechanism molecular mutations Next-generation sequencing oncogene oncogenesis papillomavirus positive promote promoted provide random regulatory region responsible sequence super-enhancer transcript Transcription tumors Type unique upstream Viral viral DNA viral genome virus
[DOI] 10.1371/journal.pgen.1007179 PMC 바로가기 [Article Type] Research Article

Activation of the c-Jun NH 2 -terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun

Article

Published on 2017-12-132022-11-01
Journal: Cell Death & Disease [Category] Coronavirus,

The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/MDA5 activation

Research Paper

Published on 2017-07-252022-10-28
Journal: Oncotarget [Category] Coronavirus,

Detection of alpha- and betacoronaviruses in rodents from Yunnan, China

Research

Published on 2017-05-262022-10-28
Journal: Virology Journal [Category] Coronavirus, MERS,

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

심혈관 질환의 83개 혈장 단백질 바이오마커에 대한 79개 유전자좌 매핑

Research Article

Published on 2017-04-032022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect Analysis approach association associations Author automated Biomarker Blood blood concentration bystander can be used cardiovascular disease cause Cell classic Combination Concentration Coronary artery Coronary artery disease correlation CVD determine disease Epidemiology eQTL evaluate Evidence evidence of expression expression quantitative trait loci Genetic genetic regulation Genetic variant genetic variants genome-wide association genome-wide significant genotyping GWA higher risk highlight human disease identify implicated individual individuals information involved knowledge large cohort leads Ligand loci majority manual curation mapping matrix metalloproteinase mechanism multiplexed immunoassay novel offer plasma plasma protein plasma proteins Protein protein expression protein level protein levels Proteins provide Quantitative RANK recent regulate Regulation Regulatory replicated risk Risk factors stem cell stem cell factor targets text mining the disease turn upstream validation study variant
[DOI] 10.1371/journal.pgen.1006706 PMC 바로가기 [Article Type] Research Article

A genetic switch controls the production of flagella and toxins in Clostridium difficile

유전자 스위치는 Clostridium difficile의 편모 및 독소 생성을 제어합니다

Research Article

Published on 2017-03-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate addition antibiotic Bacteria Bacterial Bacterial infection bacterial pathogen cause characterization Clostridium difficile colonization Control Coordinate Course degrade described determinant determine detrimental effect diarrheal diarrheal disease disease early stage Effect engage enzyme epithelial cells Evidence expressed expression Factor flagella flagellar flagellar gene flagellum Gene Expression Gene regulation Genes Genetic growth Host host tissue Impact in vitro inactivation independent independent of Infection intestinal intestinal epithelial cells intestine inversion isolates mechanism motility mRNA Mutagenesis occur Orientation pathogen phase produced promote regulate Regulation regulator Regulatory responsible secrete secreted secretion sequence severity SigD Structure toxin toxins tyrosine upstream virulence virulence factors
[DOI] 10.1371/journal.pgen.1006701 PMC 바로가기 [Article Type] Research Article