Novel coronavirus-like particles targeting cells lining the respiratory tractResearch Article Published on 2018-09-052022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 protein baculovirus Cell ciliated cell concerning displaying evaluated expressed expressing expression HCoV-NL63 Major novel Particle platform produced Production purification purified Research respiratory tract structural protein tissue tropism vaccine candidates Viral vector VLP VLPs [DOI] 10.1371/journal.pone.0203489 PMC 바로가기 [Article Type] Research Article
A review of candidate therapies for Middle East respiratory syndrome from a molecular perspectiveReview Published on 2017-09-302022-10-29 Journal: Journal of Medical Microbiology [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Antibiotics antiviral peptide camostat cathepsin L clinical trials Combination Controlled clinical trial convalescent convalescent plasma Corticosteroids current therapy DPP4 East effective furin protease GLS-5300 glycopeptide antibiotic high mortality rate host proteases include inhibitor interferon interferons laboratory-confirmed Lopinavir Lopinavir–ritonavir M(pro) Medline database MERS-CoV Middle East molecular monoclonal antibodies mortality rate Mutation pandemic Perspective PL(pro) potential therapy protease required respiratory syndrome coronavirus ribavirin S protein SARS-CoV searched subject syndrome Therapies therapy TMPRSS2 Transmissibility urgency Vaccine vaccine candidates Variation viral S protein [DOI] 10.1099/jmm.0.000565 PMC 바로가기 [Article Type] Review
Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015Online Report Published on 2016-08-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Affect animal models Combination coronavirus Developing Dromedary Epidemiology Human international public health International Vaccine Institute MERS MERS coronavirus MERS-CoV Middle East Middle East respiratory syndrome Ministry of Health organizations Pathogenesis platform prevention public health researcher robust Saudi Arabia South Korea Spike protein syndrome therapeutic therapeutic antibodies Transmission Vaccine vaccine candidates Vaccine development Vaccines viruses workshop zoonosis [DOI] 10.3201/eid2208.160229 PMC 바로가기 [Article Type] Online Report
Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious DiseasesResearch Article Published on 2015-12-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] alleles Analysis B-cell B-cell epitope candidate Cellular immune response Coverage CTL CTL epitope CTL epitopes cytotoxic T lymphocyte Diseases dominant effective elicit epitope helper T-cell epitope helper T-cell epitopes HLA binding Immune Epitope Database Immunity immunogen induce Infectious disease linear majority mapped MERS MERS-CoV Middle East neutralizing antibody nucleocapsid pandemic pathogen peptide Population Protective protective neutralizing antibody Protein provide public health Region respiratory syndrome coronavirus screened Screening screening strategy selected sequence T-cell T-cell Response target the N protein Vaccine vaccine candidates Vaccine development was performed [DOI] 10.1371/journal.pone.0144475 PMC 바로가기 [Article Type] Research Article
Coronavirus virulence genes with main focus on SARS-CoV envelope geneArticle Published on 2014-08-022022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus virus infection [DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article
Vaccines to prevent severe acute respiratory syndrome coronavirus-induced diseaseArticle Published on 2007-04-092022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] 2003 acute respiratory syndrome After animal models approach Coronaviruses described develop diagnose disease DNA vaccines effective Efficacy and safety effort Epidemic genetics Genome heterologous expression humans inactivated viruses led to less other coronaviruses performed Prevent RNA viruses Safe SARS Coronavirus SARS-CoV serotypes Side effects subunit vaccines Trial vaccination Vaccine vaccine candidate vaccine candidates Vaccines virus Virus-like particle VLPs [DOI] 10.1016/j.virusres.2007.01.021 PMC 바로가기 [Article Type] Article