From Alpha to Omicron BA.2: New digital RT-PCR approach and challenges for SARS-CoV-2 VOC monitoring and normalization of variant dynamics in wastewaterArticle Published on 2022-11-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] approach circulation Concentration COVID-19 COVID-19 pandemic discrimination Epidemic fecal France Genome sequencing greater human population immune response immunized incidence Local MONITOR New normalization omicron Paris pathogenicity Patient PMMoV populations prevalent proportion public health resulting risk RT-PCR SARS-CoV-2 selection of variant Sequencing Severity of infection specific mutation Spread statistically strain subject suggested the SARS-CoV-2 genome Transmissibility Vaccination strategy Variability variant variants of concern Variation viral dynamics viral spread virus VoC VOCs wastewater [DOI] 10.1016/j.scitotenv.2022.157740 PMC 바로가기
Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2Article Published on 2022-11-152023-07-10 Journal: Cell Reports [Category] COVID19(2023년), [키워드] allelic preference broadly neutralizing COVID-19 CP: Immunology CP: Microbiology Data mining public antibody SARS-CoV-2 Sequence analysis variants of concern [DOI] 10.1016/j.celrep.2022.111650 PMC 바로가기
Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
The spike gene target failure (SGTF) genomic signature is highly accurate for the identification of Alpha and Omicron SARS-CoV-2 variantsArticle Published on 2022-11-082022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] 95% CI Accuracy Alpha variant Amino acid Analysis B.1.1.529 B.1.1.7 cause Del detect evaluated genomic Laboratory Mutation omicron positive Positive predictive value Protein resulting RT-PCR S gene SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 variant Sensitivity and specificity sequenced Sequencing spike gene TaqPath tested the Spike Thermo Fisher variant variants of concern VoC [DOI] 10.1038/s41598-022-21564-y PMC 바로가기
Neutralizing response elicited by homologous and heterologous prime booster vaccination against ancestral SARS-CoV-2 B.1, P.1, C.37 and B.1.617.2 variantsArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] analysed B.1 B.1.617.2 BBIBP-CorV booster vaccination ChAdOx1-S Combination country COVID-19 elicited exhibited Gam-COVID-Vac greater Heterologous heterologous vaccination homologous immunized information mRNA-1273 mRNA-1273 vaccines Neutralizing Neutralizing antibodies non-replicative P.1 participant percentage Population protocol protocols provided SARS-CoV-2 second dose serum shortage significantly significantly lower vaccination Vaccination strategies Vaccination strategy Vaccine variant variants of concern viral vector-based [DOI] 10.1016/j.vaccine.2022.10.021 PMC 바로가기
Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trialArticle Published on 2022-11-082022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] adaptive anti-COVID-19 IVIG antivirals clinical evidence clinical trial collected convalescent convalescent plasma COVID-19 cumulative death Efficacy eligibility criteria evaluate Health hyperimmune immunization immunomodulators intravenous Intravenous immunoglobulin low dose monoclonal antibodies Neutralizing non-specific novel Novel coronavirus outcome Passive passive immunization Patient phase Pneumonia polyclonal polyclonal antibodies Pooled convalescent plasma Potential treatment Randomized Randomized controlled trial receive Recovered COVID-19 patients reported SARS CoV-2 SARS-CoV-2 sealed Secondary outcomes severe COVID-19 severe COVID-19 patient severe COVID-19 patients Standard of care Steroids Study protocol therapeutic option therapy treat Treatment Trial variant variants of concern virus virus particles World Health Organization [DOI] 10.1186/s13063-022-06860-2 PMC 바로가기
Evaluating correlates of protection for mix-match vaccine against COVID-19 VOCs with potential of evading immunityArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] appear Bayesian Beta ChAdOx1 Clinical efficacy Correlate of protection COVID-19 D614G Delta Delta VOC distribution Efficacy ENhance evaluate Evaluating finding Heterologous highlight homologous Immunity inversion Mix-match mRNA-1273 neutralizing antibody omicron pandemic phase 3 trial predicted Predictive previous study provide ranged reduction reductions in strain vaccination Vaccine variant variant of concern variants variants of concern VoC VOCs was used while Wuhan [DOI] 10.1016/j.vaccine.2022.10.011 PMC 바로가기
ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific mannerArticle Published on 2022-11-052022-11-16 Journal: Communications Biology [Category] SARS, 변종, [키워드] accumulated ACE2 ACE2 receptor binding binding site caused cellular changes in conserved Delta glycan glycosylation glycosylation deletion glycosylation site Guidance Interaction investigated lineages modulate mutated N-glycosylation omicron parental profile provide SARS-CoV-2 SARS-CoV-2 spike protein soluble ACE2 spike spike mutation the SARS-CoV-2 therapeutic use variant variants of concern virus VOCs [DOI] 10.1038/s42003-022-04170-6 PMC 바로가기
Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamstersArticle Published on 2022-11-042022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Antigen B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta block Community COVID-19 vaccine current Delta delta variant detectable Efficacy eliminating expressed Fever Gamma hamster immunization Lineage Lung pathology maintain Neutralizing antibody response omicron P.1 pandemic predominant Prevent PROTECT SARS-CoV-2 strains SARS-CoV-2 variant sequence Spread titre Transmission Vaccine variants variants of concern vectored vaccine virus VoC VOCs [DOI] 10.1038/s41467-022-34439-7 PMC 바로가기
RASCL: Rapid Assessment of Selection in CLades through molecular sequence analysisArticle Published on 2022-11-022022-11-16 Journal: PLoS ONE [Category] SARS, 변종, 치료기술, [키워드] acting Analysis assessment automatically COVID-19 pandemic dataset datasets detect evaluate Evolution Genome Genome sequences genomes genomic include Intensive Lineage lineages molecular Mutation natural selection Notation object pathogen Phylogenetic Rapid SARS-CoV-2 selected Selection selective sensitivity sequence Sequence analysis sequencing error Surveillance underlie unmet need variants of concern whole genes yielding [DOI] 10.1371/journal.pone.0275623 PMC 바로가기