Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, BrazilArticle Published on 2022-10-212022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] addition affected age Brazil caused concern COVID-19 COVID-19 case COVID-19 cases death deaths disease epidemiological fluctuation Gamma Gender genetic variants Host Impact individual men nasopharynx P.1 pandemic Patient replaced replacement SARS-CoV-2 SARS-CoV-2 lineage significant increase study period symptomatic the patient the SARS-CoV-2 variant variant of concern Viral load VoC [DOI] 10.3390/v14102314 PMC 바로가기
Evidence for the spread of SARS-CoV-2 and olfactory cell lineage impairment in close-contact infection Syrian hamster modelsArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition Administered assigned caused Cell cells changes in close contact complication of COVID-19 Contact days post infection detectable examined group groups hamster highest immature Impact impairment indicated Infection Lineage lung lung damage lung; nose occurred olfactory Olfactory epithelium olfactory receptor cells ORN ORNs pathogenesis of COVID-19 patients with COVID-19 receptor SARS-CoV-2 short-term cohabitation. significantly Spread subsequent tissue tissue damage transmitted uninfected unique Viral load viral presence Viral transmission virus [DOI] 10.3389/fcimb.2022.1019723 PMC 바로가기
Sensitivity analysis of rapid antigen tests for the Omicron SARS-CoV-2 variant detection from nasopharyngeal swab samples collected in Santiago of ChileArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Antigen circulation collected Contagion contagiousness COVID-19 COVID-19 pandemic decrease Detection sensitivity evaluate faster genomic greater Health authority highlight immune evasion increasingly indicate Infection limit Local Mutation nasopharyngeal swab sample NPSs omicron Omicron detection outbreak pandemic pandemic in Chile Patient predominant Prevent rapid antigen test RAT RATs reduce RT-PCR RT-qPCR SARS-CoV-2 SARS-CoV-2 variant sensitivity suggested tested the SARS-CoV-2 virus variant viral amplification Viral load viral loads Viral variants VoC [DOI] 10.3389/fpubh.2022.976875 PMC 바로가기
Individual-based modeling reveals that the COVID-19 isolation period can be shortened by community vaccinationArticle Published on 2022-10-202022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI approach B.1.617.2 baseline BNT162b2 vaccine booster vaccination Community Contact COVID-19 Delta Effect effective vaccine emotional Impact individual infected individual infected individuals Infection Isolation less likelihood mitigate nonpharmaceutical intervention occur outbreak profile Psychological quarantine reduce reveal risk Secondary infection subsequent sustained the patient the SARS-CoV-2 Transmission transmission of SARS-CoV-2 vaccination Vaccine-induced immunity variant Viral load [DOI] 10.1038/s41598-022-21645-y PMC 바로가기
SARS-CoV-2 wastewater monitoring using a novel PCR-based method rapidly captured the Delta-to-Omicron ΒΑ.1 transition patterns in the absence of conventional surveillance evidenceArticle Published on 2022-10-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] absence acquisition amplify Analysis applicability approach characterized clinical sample Conventional Delta delta variant Delta wave dependent on described doubling early warning epidemic wave epidemiological situation Epidemiology Evidence genomic genomic region genotyping Greece influence information Measures methodology omicron Omicron BA.1 PCR amplification PCR-based method plant Prevalence proportion provide Public health interventions quantification rapid increase reached real-time RT-PCR reported SARS-CoV-2 SARS-CoV-2 surveillance selective Sequencing state Surveillance surveillance data Thessaloniki variant Viral load virus wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.156932 PMC 바로가기
COVID-19 and Gut InjuryArticle Published on 2022-10-202022-11-15 Journal: Nutrients [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 bind change children coronavirus COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death develop disorder females GI Tract Gut high risk host cell IBD increased risk Inflammatory Inflammatory bowel disease inflammatory cell inhibitor Injury mechanism microbiota monoclonal antibody pandemic Pathologies Patient Probiotics receptor recruitment reduce Respiratory system SARS-CoV-2 secreted cytokine severe COVID-19 susceptible Symptom the disease the patient therapeutic option Viral load [DOI] 10.3390/nu14204409 PMC 바로가기
Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19Article Published on 2022-10-192022-11-15 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI Administered administration Adverse affected analysed antiviral therapy Antiviral treatment ARMS baseline changed Combination combination therapy concentrations conducted coronavirus 2 COVID-19 COVID-19 pandemic Day Dose escalation doses double-blind double-blind trial drug level effective Efficacy evaluate the effect event Favipiravir healthy Interaction Lopinavir-ritonavir measure monotherapy Odds ratio Outpatient participant Participants Phase 2 Placebo placebo-controlled placebo-controlled trial placebos plasma primary analysis Primary outcome provided randomised recruited reduced respiratory SARS-CoV-2 SARS-CoV-2 viral load significant interaction significantly study population symptom onset the mean trajectory Treatment undetectable United Kingdom Viral load virus [DOI] 10.1371/journal.pmed.1004120 PMC 바로가기
SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse ModelArticle Published on 2022-10-162022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] animal model B.1.1.7 B.1.1.7 variant expected greater higher infectivity Human immune system human lung tissue humanized humanized mice immune cells Immune profile immune response Immunity Infection Infectivity lesion Lineage lung lung organoid mice Model mouse no difference overlapping Pathogenesis pathogenesis of SARS-CoV-2 profile replication of SARS-CoV-2 required Research SARS-CoV-2 SARS-COV-2 infection similarity Support supported sustained Th1 Th2 variant variants of concern Viral load viral variant Viral variants virus [DOI] 10.3390/v14102272 PMC 바로가기
Comparison and Harmonization of Different Semi-Automated and Automated qRT-PCR Assays in the Assessment of SARS-CoV-2Article Published on 2022-10-122022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis Applying assays assessment automated carried comparability Concentration COVID-19 cycle threshold Cycle threshold value detectable diagnostics FIVE harmonization highlight identify infected individuals Isolation Laboratory lowest mandatory oropharyngeal swab Patient qRT-PCR qRT-PCR assay Qualitative Quantitative quantitative reverse transcriptase-polymerase chain reaction RIDA SARS-CoV-2 SARS-CoV-2 qRT-PCR sensitivity significant difference significantly the median Viral load [DOI] 10.3390/v14102239 PMC 바로가기
Genetic Load of SARS-CoV-2 in Aerosols Collected in Operating TheatersArticle Published on 2022-10-112022-11-15 Journal: Applied and Environmental Microbiology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] aerosol aerosol-generating procedure analyzed Care collected Concentration concentrations conducted coronavirus COVID-19 COVID-19 pandemic COVID-19 test Critical equipment evaluate genetic material Health Health care worker health care workers healthcare highlight implementation infected with SARS-CoV-2 information load measure N1 and N2 Operating room operating theaters outbreak Patient patients Potential presenting Prevent preventative measure preventive measure Protective protocol regions risk of COVID-19 RNA RT-qPCR Sample SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 RNA SARS-CoV-2 virion Surveillance the patient the SARS-CoV-2 Transmission Viral load virus [DOI] 10.1128/aem.01297-22 PMC 바로가기