virion – Page 12 – Communicable Diseases Research

Drugs repurposing against SARS-CoV2 and the new variant B.1.1.7 (alpha strain) targeting the spike protein: molecular docking and simulation studies

Research article

Published on 2021-08-172022-10-05
Journal: Heliyon [Category] 신약개발,

Recombinant SARS-CoV-2 Nucleocapsid Protein: Expression, Purification, and Its Biochemical Characterization and Utility in Serological Assay Development to Assess Immunological Responses to SARS-CoV-2 Infection

Article

Published on 2021-08-162022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] Bacterial bacterial cell bind biochemically C-terminal domain can be used characterization complex conserved contribute coronavirus COVID-19 COVID-19 infection CTD detect develop development diagnostic diagnostics ELISA ELISAs EMSA enzyme-linked immunosorbent assay exhibit Express expressed form immunogenic lysate mAb monoclonal antibody N protein N-terminal domain NTD nucleocapsid packaged Particles Protein purified recombinant regions response ribonucleoprotein RNA RNA-binding protein RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N SARS-CoV-2 nucleocapsid sensitivity Serological assay seropositive serum samples single-stranded soluble fraction specificity ssRNA the SARS-CoV-2 viral RNA genome virion
[DOI] 10.3390/pathogens10081039 PMC 바로가기 [Article Type] Article

Comparing antiviral strategies against COVID-19 via multiscale within-host modelling

Mathematics

Published on 2021-08-112022-10-28
Journal: Royal Society Open Science [Category] COVID-19,

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies

SARS-COV-2 스파이크 단백질에서의 시그니처 중화 항체로의 탈출

Research Article

Published on 2021-08-052022-08-13
Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 ACE2 binding ACE2 receptor Affect Alter Amino acid amino acid substitution amino acids Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody neutralization binding Cell changes in circulating Combination convalescent core COVID-19 Critical Determining develop diagnostics E484K elicited engage enzyme evade Evolution explanation grid Host host immunity hotspot identify Immune escape immune escape mutants immune evasion in silico increase Infection Interaction K417N lentivirus MONITOR Mutation mutations N501Y Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing-antibody Pandemics Protein provide provided pseudotyped lentiviruses Recognition reduce responses SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV2 sera shown signature specificity Spike protein target targets tested the spike protein Therapies understanding vaccination Vaccine variants variants of concern Viral Viral protein virion virus
[DOI] 10.1371/journal.ppat.1009772 PMC 바로가기 [Article Type] Research Article

Noroviruses—The State of the Art, Nearly Fifty Years after Their Initial Discovery

Review

Published on 2021-08-042023-08-29
Journal: Viruses [Category] E형 간염,

[키워드] clinic detection Epidemiology Evolution Genome Immunity model systems Norovirus Phylogeny Replication treatment and prophylaxis virion
[DOI] 10.3390/v13081541 PMC 바로가기 [Article Type] Review

Direct Evidence of Active SARS-CoV-2 Replication in the Intestine

장에서 활동적인 SARS-COV-2 복제의 직접적인 증거

Major Articles and Commentaries

Published on 2021-08-012022-09-06
Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, MERS, SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 carried Clinical data clinically collected Colon coronavirus coronavirus disease Coronavirus disease 2019 coronavirus virion cough COVID-19 diagnosed with COVID-19 Direct discharge discharged distribution electron microscopy eosin epithelial cells evaluate Evidence evidence of explain Fecal–oral transmission Fever Follow-up hematoxylin hematoxylin-eosin stain histopathological examination hospital Hospitalization Ileostomy Immune cell immunofluorescence Immunohistochemical analysis Incubation period infiltrating intestinal epithelial cell intestinal epithelial cells intestinal infection rectal cancer intestinal mucosa intestinal tract intestine investigated lamina propria lymphocyte Lymphocytes Macrophage macrophages Microscopy mucosal damage nucleic acid pathological change pathological changes Patient patients positive provided rectal adenocarcinoma rectal mucosa rectal specimen rectal specimens rectal tissue rectal tissues rectum Replication respiratory Result reverse transcriptase RNA RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 replication SARS-CoV-2 virion SARS-CoV-2 virions severe acute respiratory syndrome Coronavirus specimen succus entericus surgical surgical rectal tissue surgical rectal tissues surgical resection surgical specimen surgical specimens Typical Ultrathin section Ultrathin sections virion virions was performed
[DOI] 10.1093/cid/ciaa925 PMC 바로가기 [Article Type] Major Articles and Commentaries

Virtual screening and dynamics of potential inhibitors targeting RNA binding domain of nucleocapsid phosphoprotein from SARS-CoV-2

SARS-CoV-2의 뉴클레오캡시드 인단백질의 RNA 결합 도메인을 표적으로 하는 잠재적 억제제의 가상 스크리닝 및 역학

Article

Published on 2021-08-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, 치료법,

[키워드] Antiviral binding binding domain binding energy binding free energy calculated coronavirus coronavirus disease COVID-19 database databases docking docking process docking score docking scores drug exonuclease fluctuation genetic material hotspot inhibitor Interaction Ligand mechanism molecular molecular dynamics Molecular dynamics simulation N protein nucleocapsid Nucleocapsid phosphoprotein nucleocapsid phosphoprotein. outbreak pandemic Potential treatment Precision PubChem PubChem database remained required RMSD RMSF RNA SARS-CoV-2 selected Site target target protein transcribed Transcription unique viral replication virion Virtual screening virus zidovudine
[DOI] 10.1080/07391102.2020.1778536 PMC 바로가기 [Article Type] Article

CAR Macrophages for SARS-CoV-2 Immunotherapy

Immunology

Published on 2021-07-232022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

Sodium Toxicity in the Nutritional Epidemiology and Nutritional Immunology of COVID-19

Perspective

Published on 2021-07-222022-10-30
Journal: Medicina [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome addition aggregate association Bell’s palsy cardiac arrhythmias cause clearance comorbid condition coronavirus COVID-19 diabetes dietary dietary intake dietary sodium intake disease Epidemiology etiology Evidence Factor Fever Government hepatic disease hypertension immunology impair Increased increases in inflammatory immune response Kidney disease mechanism morbidity and mortality mucosal immune mucosal immune system multiple sclerosis nasal nutritional epidemiology nutritional immunology obesity Outbreaks pathophysiology Pneumonia processed Pulmonary edema reduce reduced SARS-CoV-2 SARS-COV-2 infection Sepsis sodium sodium toxicity stroke sweating symptoms of COVID-19 syndrome Systemic sclerosis thrombosis Toxicity virion Virology
[DOI] 10.3390/medicina57080739 PMC 바로가기 [Article Type] Perspective

Multivalent binding of the partially disordered SARS-CoV-2 nucleocapsid phosphoprotein dimer to RNA

RNA에 부분적으로 무질서한 SARS-CoV-2 뉴클레오캡시드 인단백질 이량체의 다가 결합

Article

Published on 2021-07-202022-09-11
Journal: Biophysical Journal [Category] SARS, 치료기술, 치료법,

[키워드] acute respiratory syndrome aggregation autoproteolysis bind binding biochemical technique Combination complex complexes core coronavirus Critical dimeric disorder domain experiment experiments explain fragment of heterogeneous identify Infection infection cycle infective interact Interaction isothermal titration calorimetry linkers maturation membrane multivalent N protein N proteins NMR nucleocapsid Nucleocapsid phosphoprotein nucleotide oligomers protease Proteases PROTECT Protein purity Replication RNA SARS-CoV-2 nucleocapsid scattering severe acute respiratory syndrome Coronavirus Spike protein susceptibility the N protein ultracentrifugation Viral RNA virion virus
[DOI] 10.1016/j.bpj.2021.03.023 PMC 바로가기 [Article Type] Article