Mutation-Specific SARS-CoV-2 PCR Screen: Rapid and Accurate Detection of Variants of Concern and the Identification of a Newly Emerging Variant with Spike L452R Mutation돌연변이 관련 SARS-CoV-2 PCR 화면: 관심 변이체의 신속하고 정확한 탐지 및 Spike L452R 돌연변이를 포함하는 새로 출현하는 변이체 식별Article Published on 2021-07-192022-09-11 Journal: Journal of Clinical Microbiology [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted approach assays B.1.1.7 center concern Concordance Control coronavirus costly defined detect detection disease control Early detection FIVE genomic genomic sequencing identification Intensive isolate L452R long term multiplex mutated Mutation newly emerging SARS-CoV-2 variant P.1 PCR PCR-based assay prevention Rapid SARS-CoV-2 SARS-CoV-2 PCR screening method spike strain Surveillance triggered United States variant variant screening variants of concern variants of interest virulent VoC WGS whole-genome sequencing [DOI] 10.1128/JCM.00926-21 PMC 바로가기 [Article Type] Article
Dissemination and evolution of SARS-CoV-2 in the early pandemic phase in South America남미의 초기 전염병 단계에서 SARS-CoV-2의 보급 및 진화Article Published on 2021-07-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Americas Analysis analyzed independently Bayesian approach Brazil Characteristics clade clades concerning Coronavirus-2 country decrease demonstrated dissemination Ecuador Evolution of SARS-CoV-2 frequencies Frequency genomic indicated Infection information Lineage pandemic pandemic spread phylodynamic Prevalence prevalent reduction respiratory sampling SARS Coronavirus SARS-CoV-2 Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly social movement South South America Spread stationary stationary phase Suriname These data Viral virulence virus WGS Whole-genome sequence [DOI] 10.1002/jmv.26967 PMC 바로가기 [Article Type] Article
Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional StudyMicrobiology Published on 2021-06-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] analyzed association Bacteria clinical disease component controls coronavirus SARS-CoV-2 correlated COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients determine Dysbiosis Evidence fungi GM-CSF Gut identify IgA response IL-17 immune response Immunoglobulin Inflammation Inflammatory cytokines Local local immune response local inflammation marker microbial community Microbiome mucosal oral Oral microbiome other diseases pandemic parameter PCR primary site pro-inflammatory cytokine progression Protective quantified Replication respiratory virus response SARS-COV-2 infection secretory IgA shown significantly subjects susceptibility symptom severity symptomatic patient systemic diseases the SARS-CoV-2 therapy TNFα to define Vaccine development virus virus infection virus replication viruses WGS [DOI] 10.3389/fmicb.2021.687513 PMC 바로가기 [Article Type] Microbiology
Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance말라위에서의 시겔라 전체 유전체 서열 분석이 플루오로퀴놀론 내성을 확인하다Article Published on 2021-05-042024-07-30 Journal: Microbial Genomics [Category] 세균성이질, [키워드] AMR FQR Shigella WGS [DOI] 10.1099/mgen.0.000532 PMC 바로가기
Rapid Spread of the SARS-CoV-2 Variant of Concern 202012/01 in Southern Italy (December 2020–March 2021)남부 이탈리아에서 SARS-CoV-2 우려 변종 202012/01의 급속한 확산(2020년 12월–2021년 3월)Article Published on 2021-04-292022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] Apulia B.1.1.7 Clinical characteristics closure concern COVID-19 demographic and clinical characteristics Europe evaluate General population group Hospitalization implementation Intervention Italy Local lockdowns NPI NPIs positive sample proportion Rapid robust S gene S gene target failure SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants School Schools Spread statistical analysis strain Strengthened study period subset Surveillance symptomatic the SARS-CoV-2 Vaccine variants of concern virological study VoC VOC 202012/01 VOC 202012/01-B.1.1.7 lineage SARS-CoV-2 VOCs was performed WGS whole-genome sequencing [DOI] 10.3390/ijerph18094766 PMC 바로가기 [Article Type] Article
How Genetics Might Explain the Unusual Link Between Malaria and COVID-19Medicine Published on 2021-04-262022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome allele frequency coronavirus coronavirus disease correlations COVID-19 COVID-19 case COVID-19 cases demonstrated Epidemiology Evidence experiment Frequency Genes genetic information genetic variants Genomics help highest Hypothesis incidence increase Italy lowest malaria molecular mechanism pandemic Population positive Prevent reported SARS-COV-2 infection selected severity significantly subject subset therapeutic options variant WGS whole-genome sequencing whole-genome sequencing analysis [DOI] 10.3389/fmed.2021.650231 PMC 바로가기 [Article Type] Medicine
Virus-derived variation in diverse human genomes다양한 인간 게놈의 바이러스 유래 변이Research Article Published on 2021-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition addition Analysis applied biosafety can not cell line cell lines chromosomal chromosome chromosomes coevolution complex computational tool computational tools contributing to dataset described example expand experiment full-length gene conversion Gene Expression gene transfer generate genetic material Genetic variant Genetic variation Genome genome region Haplotype HERV HERV-K HHV-6 HIV-1 Host Human human endogenous retrovirus human endogenous retrovirus-K human endogenous retroviruses Human genome Human genomes human herpesvirus 6 Human immunodeficiency virus human T lymphotropic virus humans inaccessible include Infection introgression LCLs Linkage disequilibrium loci lymphoblastoid cell lymphoblastoid cell lines make up mapped nucleotide Perspective progenitor cell progenitor cells reads Reference materials sequence sequenced sequences Sequencing short-read sequencing Single nucleotide variant single nucleotide variants SMRV SNVs squirrel monkey squirrel monkey retrovirus Structural variant subjects SVs These cells transfer variant variants Variation virus virus infection viruses WGS whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1009324 PMC 바로가기 [Article Type] Research Article
Analysis of SARS-CoV-2 genomic epidemiology reveals disease transmission coupled to variant emergence and allelic variationSARS-CoV-2 게놈 역학 분석은 변이 출현 및 대립 유전자 변이와 결합된 질병 전파를 보여줍니다Article Published on 2021-04-012022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] a metric allelic Analysis association bioinformatics changes in China comparison Computational biology and bioinformatics country COVID-19 incidence creation cumulative Decision making defined determine direct association disease disease outbreak disease transmission Diseases epidemic curve Epidemiology estimate Evolution examined genetics Genome genome sequence Genome sequencing genomic Genomic analysis genomic variation had no identity incidence Increases increases in Infection infection process Inference information initial instantaneous integration Local Medical research metric Microbiology Microbiology techniques modeling Mutation mutation rate outbreak pandemic pathogen Pathogenesis PCR Population population density predict predicted Predictive progression real time reproductive required reveal SARS-CoV-2 severity SNP SNPs Spread Stage stages Surveillance Systems biology takeoff temperature the epidemic Transmission variant variants Variation Viral viral genome Viral mutations virus genome were used WGS [DOI] 10.1038/s41598-021-86265-4 PMC 바로가기 [Article Type] Article
Transmission of SARS-CoV-2 among healthcare workers and patients in a teaching hospital in the Netherlands confirmed by whole-genome sequencing전체 게놈 시퀀싱으로 확인된 네덜란드의 한 교육 병원의 의료 종사자와 환자 간의 SARS-CoV-2 전파Article Published on 2021-04-012022-09-11 Journal: The Journal of hospital infection [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Admission Cluster Contact coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 cohort diagnosed with COVID-19 early stage early stages epidemiological Evidence finding HCW HCWs healthcare worker Healthcare workers hospital Hospitalized Infection Isolation Molecular typing Netherland Netherlands nine outbreak pandemic Patient patients physical distancing positive SARS-CoV-2 sequence Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Transmission were infected WGS WGS. whole-genome sequences whole-genome sequencing [DOI] 10.1016/j.jhin.2021.02.005 PMC 바로가기 [Article Type] Article
Genomic surveillance of SARS-CoV-2 in the Republic of Congo콩고공화국에서 SARS-CoV-2의 게놈 감시Article Published on 2021-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African assigned carried clade Clusters collected contributing to coronavirus Ct values D614G database Genome genomes Genomic surveillance Illumina individual information Lineage Lineage B1 Mutation Next-generation sequencing NGS pangolin provide Republic of Congo RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage SARS-CoV-2 sequence SARS-CoV-2 variants screened sequenced severe acute respiratory syndrome Coronavirus shown spike mutation submitted Surveillance Transmission virus WGS Whole genome sequencing whole-genome sequencing [DOI] 10.1016/j.ijid.2021.03.036 PMC 바로가기 [Article Type] Article