In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 치료를 위한 하이드록시클로로퀸의 시험관 내 항바이러스 활성 및 최적화된 투여 설계의 예측Major Article Published on 2020-03-092022-09-10 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 비임상, [키워드] activity acute respiratory syndrome coronavirus advance autoimmune conditions breath China Chloroquine Chloroquine phosphate Concentration coronavirus coronavirus 2 Critically ill cytokine Cytokine storm Dosing dosing regimen drug effective Evidence followed by Hydroxychloroquine hydroxychloroquine sulfate immunomodulatory effect in vitro in vitro data inhibit SARS-CoV-2 Loading dose lung maintenance dose malaria mechanism of action occur pharmacokinetic pharmacological phosphate projection reached regimen respiratory Result safety profile SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread sulfate Support the cytokine storm tolerable treat treating SARS-CoV-2 infection use of hydroxychloroquine Vero cells was tested Wuhan [DOI] 10.1093/cid/ciaa237 PMC 바로가기 [Article Type] Major Article
Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological StudiesArticle Published on 2020-02-252022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus 2019-nCoV Analysis B cell B cell epitopes caused China coronavirus coronavirus 2 Coverage COVID-19 COVID-19 outbreak develop effort epitope Genetic help identification immune immunogenic immunological MERS-CoV MHC allele Mutation new virus Novel coronavirus nucleocapsid offer outbreak performed Potential Protein respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 sequence screened similarity Spread structural protein T cell epitope T cell epitopes target Vaccine Vaccine design virus [DOI] 10.3390/v12030254 PMC 바로가기 [Article Type] Article
Approaches for the Treatment of SARS-CoV-2 Infection: A Pharmacologic View and Literature ReviewReview Article Published on 2020-01-012022-10-30 Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome (ARDS) approach ARDS caused China clinical manifestations clinical trial coronavirus coronavirus 2 Coronavirus disease 2019 COVID-19 COVID-19 disease disease drugs targeting effective effective drug effort elements host cell identify knowledge literature medication Mild moderate new virus offered outcomes pandemic Pharmacologic potential therapy public health Quickly respiratory review SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severity Spread Stage suggested syndrome the disease therapy Treatment View virus [DOI] 10.22037/ijpr.2020.113821.14506 PMC 바로가기 [Article Type] Review Article