Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease SituationResearch Article Published on 2017-01-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] absence caused characterized Deletion deletions eight epidemic diarrhea Genetic genomic Genotype Infection Intact Isolation Japan Molecular epidemiology New nine novel ORF3 outbreak Outbreaks Pathogenesis PEDV pig Protein resulting S gene Seven situation strain the disease the Spike variant virus [DOI] 10.1371/journal.pone.0170126 PMC 바로가기 [Article Type] Research Article
A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other CausesResearch Article Published on 2016-11-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] acute respiratory disease acute respiratory illness Adverse adverse outcome cause city clinical clinical feature Clinical outcome clinically Comparative CoV demographics diabete diarrhoea eight eligible Factor for inclusion HCW Health Health care health care workers hospital illness indicated Infection King laboratory characteristics Laboratory test MERS MERS patient MERS patients MERS-CoV MERS-CoV infection Middle East nine Older age Other outcome Patient PCR positive presentation presenting respiratory risk factor RT-PCR Saudi Arabia significantly syndrome tested variable [DOI] 10.1371/journal.pone.0165978 PMC 바로가기 [Article Type] Research Article
Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes다른 동일한 tRNA 유전자의 조직 및 시간 특이적 발현Research Article Published on 2016-08-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogate adaptive addition Affect affected age aggregation Amino acid Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans can not changes in codon codon usage conserved disease Diseases dynamic eight element expressed expression expression level expression levels fluorescent Genes genome-wide analysis GFP hallmark Host identity intrinsic intron Intronic introns lead MONITOR mutations nematodes neurodegeneration observation orthologous gene orthologous genes Pairing predict promoter promoters Protein Protein misfolding protein sequences protein translation protein-coding gene protein-coding genes recognize regulated Regulating reporter ribosome sequence synonymous tissue tissues transcribed tRNA tRNAs Tryptophan [DOI] 10.1371/journal.pgen.1006264 PMC 바로가기 [Article Type] Research Article
Alphacoronavirus in urban Molossidae and Phyllostomidae bats, BrazilShort Report Published on 2016-06-242022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Phyllostomidae alphacoronavirus Analysis bat bats Brazil Cluster conducted coronavirus CoV Cynomop eight emerging disease Evolution finding FIVE groups Host implicated indicated molecular Molossidae Occurrence Phylogenetic analysis Phylogeny positive RdRp gene RT-PCR S gene sequence Sequencing specificity specimen Spread strain Surveillance tested [DOI] 10.1186/s12985-016-0569-4 PMC 바로가기 [Article Type] Short Report
Molecular characterization of human coronaviruses and their circulation dynamics in Kenya, 2009–2012Research Published on 2016-02-012022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Acute respiratory infection all age group amplification Analysis analyzed cells characterized children circulation diagnosed distribution eight Evidence FIVE HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Hospitalization Human human coronavirus human coronaviruses identity Immunity individual Infection information inoculated isolate Kenya MERS-CoV molecular molecular characterization monolayer morbidity nasopharyngeal specimen polymerase positive Prevalence Primers real time Respiratory illness responsible Result RT-PCR sequence homology Sequencing shown specimen specimens strain Strains Variation virus [DOI] 10.1186/s12985-016-0474-x PMC 바로가기 [Article Type] Research
Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant GenotypesArticle Published on 2015-05-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Analysis association available data Belgium characterized circulating clinical sample Cluster collected Complete coronavirus Coronaviruses detect Diversity eight Epidemic Evolution FIVE France Genotype genotypes HCoV-OC43 Human human coronavirus identification information isolate Like Lower molecular N gene New Nsp12 OC43 Phylogeny plasticity provide recombinant Recombination respiratory infections responsible sequenced Sequencing specimen Temporal analysis TMRCA USA virus viruses [DOI] 10.3390/v7052358 PMC 바로가기 [Article Type] Article
Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin [DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article
An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infectionsResearch Article Published on 2014-08-152022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] antibody baculovirus both viruses carried caused Cell clinically coronavirus Coronavirus infection domain dominant eight Evolution fatal disease Feline coronavirus Feline infectious peritonitis genotypic genotyping healthy hospital immunofluorescence assay Infection infection rate infections Population predominant Prevalence Recombinant protein Result seropositive Seroprevalence serotype Spike protein Support Taiwan the spike protein Transmission Type type I viral infection virus was used were infected [DOI] 10.1186/s12917-014-0186-7 PMC 바로가기 [Article Type] Research Article
Findings from the SASA! Study: a cluster randomized controlled trial to assess the impact of a community mobilization intervention to prevent violence against women and reduce HIV risk in Kampala, UgandaSASA의 발견! 연구: 우간다 캄팔라에서 여성에 대한 폭력을 예방하고 HIV 위험을 줄이기 위한 지역사회 동원 개입의 영향을 평가하기 위한 클러스터 무작위 통제 시험Research Article Published on 2014-07-312022-08-09 Journal: BMC Medicine [Category] 임상, [키워드] 95% CI 95% confidence interval adjusted baseline Cluster Community Community mobilization conducted Controlled trial Cross-sectional surveys defined Drivers East Africa eight Evidence finding Follow-up Gender based violence greater HIV Impact evaluation impacts implementation intention-to-treat analysis Intervention Intimate partner violence men outcome physical post intervention Prevalence Prevent Primary outcome protocol public health random Random sample Randomized controlled trial receive reduce replicated responses Result risk risk ratio Sex significantly significantly lower Study protocol sub-Saharan Africa supplementary material Trial registration Uganda Violence Violence prevention while woman women [DOI] 10.1186/s12916-014-0122-5 PMC 바로가기 [Article Type] Research Article
Genomic Profiling of Collaborative Cross Founder Mice Infected with Respiratory Viruses Reveals Novel Transcripts and Infection-Related Strain-Specific Gene and Isoform ExpressionMouse Genetic Resources Published on 2014-06-052022-10-31 Journal: G3 (Bethesda, Md.) [Category] Coronavirus, [키워드] acute respiratory syndrome aligned base pair collaborative cross conserved coronavirus differential expression eight elements expression gene transcription Genetic variation Genome genomes genomic host response identify Infection influenza A virus instance isoform isoform differential expression junctions knowledge lung mice mouse transcriptome annotation Mutation novel Profiling proportion recorded respiratory respiratory virus resulting RNA sample RNA-Seq sequence sequenced strain Strains transcribed transcript transcriptional transcriptional profile transcriptional response Transcriptome transcripts unlikely Variation viral infection [DOI] 10.1534/g3.114.011759 PMC 바로가기 [Article Type] Mouse Genetic Resources