Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans인간 곰팡이 병원체 Cryptococcus neoformans에서 Ras1, Cdc24 및 Ptp3의 고유한 역할을 통한 저산소 반응의 분자 메커니즘Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin affected Analysis biological processe biological processes C. neoforman C. neoformans CAMP caused Cdc42 central gene chromosome Compound Concentration condition conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoskeletal Deletion downstream eight ergosterol eukaryotic cells expression of gene family function fungal genes encoding genetic analysis genotoxic growth growth defect growth retardation GTPase guanine Human human host hypoxia hypoxic hypoxic condition hypoxic conditions indicated inhibit inhibitor involved maintenance molecular mutant not affected nucleotide osmotic oxygen pathogen pathway Pathways phosphatase phosphatases Phosphorylation Protein protein translation Rac1 Rac2 regulate required rescued response Rho GTPase RNA RNA sequencing role sequence similarity single cells strain Strains suggested suppressor These cells Tolerance unique wild-type strain [DOI] 10.1371/journal.pgen.1004292 PMC 바로가기 [Article Type] Research Article
A Truncated Receptor-Binding Domain of MERS-CoV Spike Protein Potently Inhibits MERS-CoV Infection and Induces Strong Neutralizing Antibody Responses: Implication for Developing Therapeutics and VaccinesResearch Article Published on 2013-12-042022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cells bind binding block caused culture supernatant Developing development Dipeptidyl peptidase 4 domain DPP4 effective eight expressed fused high mortality IgG Fc induce inhibited MERS MERS-CoV MERS-CoV infection mice Middle East neutralize Novel coronavirus Protein purified RBD RBD protein receptor reported residue respiratory infectious disease S-specific antibodies Safe Saudi Arabia spike Spread spread to Strong syndrome therapeutic Therapeutics Vaccine [DOI] 10.1371/journal.pone.0081587 PMC 바로가기 [Article Type] Research Article
An outbreak of feline infectious peritonitis in a Taiwanese shelter: epidemiologic and molecular evidence for horizontal transmission of a novel type II feline coronavirusResearch Published on 2013-07-172022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Analysis analyzed cause caused coronavirus death detected determine eight Epidemiology Evidence fatal disease fecal samples Feline infectious peritonitis found histopathological Infected Infection infectious molecular Mutation occur outbreak potential risk Recombination S gene serotype Seven Spread Taiwan tissue homogenate Transmission virus [DOI] 10.1186/1297-9716-44-57 PMC 바로가기 [Article Type] Research
Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic DermatitisGerman Shepherd Dogs의 게놈 전체 분석을 통해 아토피 피부염과 CFA 27에 대한 유전자좌 연관성 밝혀Research Article Published on 2013-05-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affected age allergic skin Analysis association atopic dermatitis Author block blocks CAD canine caused CFA chromosome Cohort compared complex contributing to Control correlation defined dermatitis detected develop different disease Disease prevalence division dog eight environmental factors expressed found Genes Genetic genetics Genome genome-wide association genome-wide significant genotyping German shepherd GSD Haplotype high correlation Human IgA level IgA levels included indicate Interaction mixed model approach parameters performed PKP2 plakophilin population stratification Prevalence sampling separation Sequencing serum significantly significantly lower skin disease SNPs study population subpopulation subpopulations subset Swedish the strongest was performed was used [DOI] 10.1371/journal.pgen.1003475 PMC 바로가기 [Article Type] Research Article
Ezrin Interacts with the SARS Coronavirus Spike Protein and Restrains Infection at the Entry StageResearch Article Published on 2012-11-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Amino acid amino-acid Cell cellular Cluster complex coronavirus cysteine cytosol dependent on domain dominant negative early stage eight endodomain envelope fusion epithelial cells event ezrin Factor finding found glycoprotein host cell membrane in vitro Infection interact Interaction Lentiviral particle limit linker mechanism membrane fusion molecular mechanisms Particle performed pseudotyped regulate Regulation respiratory RNA S-pseudotyped particle SARS-CoV SARS-CoV S severe spike Stage susceptibility targeting VERO E6 cells viral envelope virus entry Virus life cycle yeast [DOI] 10.1371/journal.pone.0049566 PMC 바로가기 [Article Type] Research Article
The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus PathogenesisReview Published on 2012-11-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein accessory proteins acute respiratory syndrome affected caused cellular China coronavirus country Effect eight ENCODE expression functional Genome homologous homologues human-to-human transmission infected individual infected individuals Infection Isolation knowledge membrane mortality rate Novel coronavirus nucleocapsid Open reading frame open reading frames ORFs predicted Protein Proteins reported Research respiratory Respiratory disease resulting role SARS-coronavirus SARS-CoV severe Spread subsequent unique virus [DOI] 10.3390/v4112902 PMC 바로가기 [Article Type] Review
Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivoArticle Published on 2012-07-202022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accessory protein accessory proteins acute respiratory syndrome Amino acid Analysis analyzed approach cellular conditions coronavirus Coronaviruses cytoplasm described eight ENCODE experiment Factor functions Genome homology immunoprecipitation in vivo infective Interaction involved LC–MS pathogenicity Protein Protein 6 Protein 9b protein–protein interactions Proteins proteomic Replication SARS Coronavirus SARS-CoV SARS-CoV infected cell SARS-CoV infected cells severe shown structural protein Viral protein virus [DOI] 10.1016/j.virusres.2012.07.012 PMC 바로가기 [Article Type] Article
Recombination in Avian Gamma-Coronavirus Infectious Bronchitis VirusArticle Published on 2011-09-232022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] analyzed antigenic diversity Area avian coronavirus Coronaviral coronavirus different eight evidence of Evolution family Coronaviridae found Frequency full-length full-length genome gamma coronavirus GenBank Genetic Genome Genotype highest IBV Infectious Bronchitis Virus isolate mechanism nonstructural protein Occurrence Recombination Region sequence sequenced spike glycoprotein strain thought virus [DOI] 10.3390/v3091777 PMC 바로가기 [Article Type] Article
Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoVResearch article Published on 2009-12-032022-10-28 Journal: BMC Immunology [Category] Coronavirus, Fulltext, MERS, [키워드] acute respiratory syndrome analyzed assays autologous binding Candidates Cell-mediated immune responses cleavage conserved coronavirus CoV CTL dendritic cell different Donor eight epitope Ex vivo full-length S protein glycoprotein healthy help identification IFN-γ immunized immunized mice immunopathology lysed mechanism Pathogenesis PBL peptide peptides Plasmid predict processed Protein Region released Result S protein SARS-CoV SARS-CoV infection sequence target cell tested the S protein the spike protein transgenic mice virus virus clearance [DOI] 10.1186/1471-2172-10-61 PMC 바로가기 [Article Type] Research article
Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoVResearch article Published on 2009-12-032022-10-27 Journal: BMC Immunology [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed assays autologous binding Candidates Cell-mediated immune responses cleavage conserved coronavirus CoV CTL dendritic cell different Donor eight epitope Ex vivo full-length S protein glycoprotein healthy help identification IFN-γ immunized immunized mice immunopathology lysed mechanism Pathogenesis PBL peptide peptides Plasmid predict processed Protein Region released Result S protein SARS-CoV SARS-CoV infection sequence target cell tested the S protein the spike protein transgenic mice virus virus clearance [DOI] 10.1186/1471-2172-10-61 PMC 바로가기 [Article Type] Research article