susceptibility – Page 121 – Communicable Diseases Research

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

인간의 SARS-CoV-2에 대한 기존 및 새로운 체액 면역

Report

Published on 2020-12-112022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, SARS, 조류인플루엔자, 진단, 치료제,

An Overview of SARS-CoV-2 and Animal Infection

Veterinary Science

Published on 2020-12-112022-11-01
Journal: Frontiers in Veterinary Science [Category] COVID-19,

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

SARS-CoV-2 폐 감염에 대한 숙주 반응의 시간적 및 공간적 이질성

Article

Published on 2020-12-092022-09-10
Journal: Nature Communications [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, 진단,

[키워드] Activation Analysis Autopsy autopsy specimens Cadaveric Combination death disease epithelial cell Evolution expression Genes heterogeneity heterogeneous high viral load host response immunohistochemistry Inflammation Inflammatory inherent interferon pathway interferon response lung lung damage Lungs Macrophage mucin pathology Patient patients with COVID-19 platform predominant Protein pulmonary epithelial cell Pulmonary infection RNA RNA expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Severity of disease specimen Spectrum surfactant susceptibility Temporal the SARS-CoV-2 virus tissue Translational research understanding Viral viral infection Viral load virus virus infection
[DOI] 10.1038/s41467-020-20139-7 PMC 바로가기 [Article Type] Article

Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus

Research Article

Published on 2020-12-092022-10-30
Journal: The Journal of General Virology [Category] COVID-19, SARS,

In vitro synergy of isavuconazole in combination with colistin against Candida auris

Article

Published on 2020-12-082022-10-04
Journal: Scientific Reports [Category] 신약개발,

Novel Molecular Evidence Related to COVID-19 in Patients with Diabetes Mellitus

Review

Published on 2020-12-072022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome affected aggravate angiotensin-converting enzyme 2 anti-inflammatory effect Asymptomatic COVID-19 Autoimmune benefit binding caused Cell cleavage clinical trial coronavirus Coronavirus disease 2019 COVID-19 COVID-19 progression cytosolic Diabetes Mellitus Dipeptidyl peptidase-4 Effectiveness Evidence exhibit facilitate furin global pandemic glycemic control glycosylation Hospitalization human Angiotensin-converting enzyme hyperglycemia immune response induce inhibitor Injury innate immune system Innate immunity Lactate lower mortality medication metabolites Mild novel outcomes pancreatic Patient patients with diabete pro-inflammatory cytokine protective effect Randomized receptor reduction in renin–angiotensin–aldosterone system S protein SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 susceptibility targets Th1 Th2 immunity the S protein TMPRSS2 transmembrane serine protease Treatment Trigger uncontrolled vicious cycle viral entry viral genome viral S protein
[DOI] 10.3390/jcm9123962 PMC 바로가기 [Article Type] Review

Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients

COVID-19로 인해 입원한 환자의 사망 및 중증 질환의 유병률 및 예측인자: 77건의 연구 및 38,000명의 환자에 대한 포괄적인 체계적 검토 및 메타 분석

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS ONE [Category] COVID-19, Medicine and Health Sciences, MERS, SARS,

[키워드] 95% CI adjusted adverse outcome adverse outcomes analyzed association China Chronic kidney disease chronic liver disease CKD CLD Comorbidities confidence interval COPD COVID-19 COVID-19 patient death determine diabete diabetes died disease Disease progression Europe fatality Health health screening heart disease heterogeneity Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients hypertension Inclusion inclusion criteria individual Infection Kidney disease male males Meta-analysis morbidity morbidity and mortality objective observational studies observational study Patient patients hospitalized predictor Prevalence Public reduce Relative risk Result risk risk factor Risk factors searched severe disease smoking susceptibility susceptibility to infection systematic review Web of Science
[DOI] 10.1371/journal.pone.0243191 PMC 바로가기 [Article Type] Research Article

Pediatric Inflammatory Multisystem Syndrome and Rheumatic Diseases During SARS-CoV-2 Pandemic

Pediatrics

Published on 2020-12-042022-10-31
Journal: Frontiers in Pediatrics [Category] COVID-19,

[키워드] acute respiratory syndrome Adults association caused children clinical Clinical course clinical history coronavirus coronavirus disease COVID - 19 COVID-19 COVID-19 patient COVID-19 research Diagnosis Europe European Evidence favor feature Features Fever form healthy healthy children hematological highlighting Immune-mediated include intensive care Kawasaki disease macrophage activation syndrome management manifestation Manifestations mechanism MIS-C Most patient multisystem inflammatory syndrome in children (MIS-C) myocarditis organ dysfunctions outbreak pandemic patients pediatric Pediatric Inflammatory Multisystem Syndrome pediatric rheumatic disease Pediatrician PIMS ranged SARS – CoV – 2 SARS-CoV-2 SARS-CoV2 severity Shock standard hospitalization susceptibility Symptoms syndrome systemic immune response systemic inflammatory systemic inflammatory disease
[DOI] 10.3389/fped.2020.605807 PMC 바로가기 [Article Type] Pediatrics

Identifying the Zoonotic Origin of SARS-CoV-2 by Modeling the Binding Affinity between the Spike Receptor-Binding Domain and Host ACE2

스파이크 수용체 결합 도메인과 호스트 ACE2 간의 결합 친화도를 모델링하여 SARS-CoV-2의 인수공통 기원 확인

Article

Published on 2020-12-042022-09-11
Journal: Journal of Proteome Research [Category] SARS, 변종, 조류인플루엔자, 치료기술,

[키워드] ACE2 ACE2 protein ACE2 proteins ACE2 variant affinity amphibians Analysis approach binding binding affinity binding energy birds calculated candidate Candidates complex structure coronavirus correlated Critical Cutoff data sets determined by disease control domain Effectiveness EvoEF2 energy unit examined feasible fish highest Host host cells human infectious disease identify identifying Infection Infectious disease intermediate host intermediate hosts investigated Laboratory mammals modeling origin primates RBD reptiles Research risk of infection rodents SARS-CoV-2 spike receptor-binding domain susceptibility the binding affinity the Spike virus wild animals zoonotic origin
[DOI] 10.1021/acs.jproteome.0c00717 PMC 바로가기 [Article Type] Article

Human Leukocyte Antigen Complex and Other Immunogenetic and Clinical Factors Influence Susceptibility or Protection to SARS-CoV-2 Infection and Severity of the Disease Course. The Sardinian Experience

인간 백혈구 항원 복합체 및 기타 면역유전학적 및 임상적 요인은 SARS-CoV-2 감염에 대한 감수성 또는 보호 및 질병 경과의 중증도에 영향을 미칩니다. 사르데냐 체험

Randomized Controlled Trial

Published on 2020-12-042022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단,

[키워드] 95% CI All participants allele alleles analyzed Asymptomatic asymptomatic or pauci-symptomatic patients Autoimmune disease Autoimmune diseases beta-thalassemia beta-thalassemia trait beta-thalassemic trait Care carried clinical Clinical data Clinical outcome clinical, genetic and immunogenetic factors collected controls Course COVID-19 severity deficiency Demographic and clinical data disease course DRB1 evaluate experience extended haplotype Factor Frequency G6PDH G6PDH deficiency Genetic genetic factor genetic factors Genetic polymorphism Glucose Glucose-6-phosphate glucose-6-phosphate dehydrogenase haplotype frequencies haplotypes health problem healthy HLA allele HLA class I HLA class I and II molecules HLA-A HLA-A*02:05, B*58:01, C*07:01 HLA-A*30:02 HLA-A*30:02, B*14:02, C*08:02 HLA-C HLA-C*04:01 allele HLA-DRB1*08:01 allele home care home care patients hospital hospital care hospitalized patient hospitalized patients Human human leukocyte antigen immunogenetic background immunogenetic factors in-patient infections influence Influenza influenza vaccination Italy Male sex material Mild disease negative influence Older age Other Participants Pathogenesis Patient patients pauci-symptomatic phosphate predisposing factor protection protective effect public health recruited related clinical consequence related clinical consequences required Result Sardinia Sardinian Sardinian control Sardinian population SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients seasonal flu severe disease Sex susceptibility Taking thalassemia the disease three-loci haplotype vaccination with mild disease without symptoms world-wide public health problem
[DOI] 10.3389/fimmu.2020.605688 PMC 바로가기 [Article Type] Randomized Controlled Trial