Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses전사체 메타 분석에 의해 발견된 중추신경계 장애와 암 사이의 역병환에 대한 분자적 증거Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Alzheimer's disease Alzheimer's disease Analysis Author biological processe biological processes cancers Candidates causes CENTRAL CNS CNS disorder Colorectal Comorbidity complex disorders conditions conducted contribute decrease Degradation deregulated deregulation described disease disorder disorders downregulated downregulation driven by Drug repurposing drug treatment drug treatments epidemiological Evidence expected expression Factors Gene Genetic genetic factors Hypothesis incidence inverse lung mechanism meta-analysis molecular nervous observé opposite overlap Parkinson's Disease pathway Pathways Patient PIN1 Probability progression promote Prostate protective effect Protein related risk Schizophrenia System tested transcriptomic Treatment understanding upregulated upregulation Wnt [DOI] 10.1371/journal.pgen.1004173 PMC 바로가기 [Article Type] Research Article
Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential TherapeuticsResearch Article Published on 2013-08-152022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 5-FU activity antiviral activity antiviral drug Author biochemical Combination compared conserved coronavirus CoV CoV replication CoVs Critical decrease demonstrated determine Epidemic Evidence Exoribonuclease Express Genetic high mutation rate human coronavirus human disease Hypothesis identify increase in inhibitor inhibitory activity lethal MERS-CoV Middle East Mutagenesis Mutation Next-generation sequencing NO nonstructural protein 14 nsp14-ExoN nucleotides Population Potential Prevent Probability Proofreading provide RdRP Replication required respiratory responsible ribavirin RNA RNA synthesis RNA virus SARS-CoV selective sensitivity severe Support susceptible target Therapeutics to define treated Vaccine viral adaptation Viral protein viral RNA synthesis virus virus virus replication while wild-type zoonotic [DOI] 10.1371/journal.ppat.1003565 PMC 바로가기 [Article Type] Research Article
Detection of human coronaviruses in simultaneously collected stool samples and nasopharyngeal swabs from hospitalized children with acute gastroenteritisResearch Published on 2013-02-052022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] 95% CI 95% confidence interval age Asymptomatic children collected Control control group coronavirus detected detected in stool detection Elective surgery etiology gastroenteritis Gastrointestinal infection healthy control healthy controls Hospitalized Human human coronavirus Human coronavirus nasopharyngeal Nasopharyngeal swab NP swab NP swabs Occurrence Odds ratio Patient Prevalence Probability real time recalled respiratory infection respiratory symptom respiratory symptoms Result RT-PCR significantly higher Stool Stool sample stools Swab tested Viral gastroenteritis virus [DOI] 10.1186/1743-422X-10-46 PMC 바로가기 [Article Type] Research
Temporal Variability and Social Heterogeneity in Disease Transmission: The Case of SARS in Hong KongResearch Article Published on 2009-08-212022-10-28 Journal: PLoS Computational Biology [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Affect applied Author average behavioural Better case change changes in Community Contact Course Critical different disease transmission effective Epidemic Epidemics epidemiological estimate event Evolution example functions General population healthcare healthcare worker Hong Kong hospital Hospitalized hospitals infect infectious influenza pandemic Markov chain mean measure observation outbreak parameter parameters Probability PROTECT provided public health measure recent reduced remained Reproduction number risk of infection SEIR shown subpopulation susceptible-exposed-infectious-removed sustained Temporal the SARS epidemic Transmission transmission rates was used were infected [DOI] 10.1371/journal.pcbi.1000471 PMC 바로가기 [Article Type] Research Article
Molecular analysis of the S1 subunit of the spike glycoprotein of respiratory and enteric bovine coronavirus isolatesArticle Published on 2002-01-302022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Allelic variation alteration Amino acid amino acid change amino acid substitution Analysis analyzed antigenic Bovine coronavirus Characteristics classical cleavage site Clustering compared diarrhea different Genetic group hydrophobicity isolate isolates led to nucleotide Phylogenetic analysis polymorphism predicted Probability Protein residue Respiratory and enteric BoCV S glycoprotein S1 subunit secondary structure sequence Sequencing significant changes in spike glycoprotein strain Strains the S1 subunit two subgroups variations [DOI] 10.1016/S0168-1702(02)00004-7 PMC 바로가기 [Article Type] Article