Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi ArabiaResearch Article Published on 2016-04-212022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] Abnormalities Administered Admission age Alanine ALT Analysis Anemia Characteristics chest X-ray clearance clinical feature Confounding Coronary artery disease coronavirus CoV creatinine CXR death determine Diagnosis disease effect of treatment Efficacy elevated evaluate evaluated Gender healthcare worker hypertension Hypoxemia increased survival independent Infection interferon beta Kingdom Laboratory Leukocytosis lung male MERS MERS CoV MERS-CoV middle Middle Eastern respiratory syndrome coronavirus Most patient multivariate logistic regression outcome overall mortality Patient PCR polymerase chain predictor randomized trial reduced renal respiratory respiratory rate Result retrospective retrospective cohort Saudi Arabia severity severity of illness survival the patient Treatment Treatment outcome treatment regimen Univariate analysis vomiting was performed was reduced [DOI] 10.1186/s12879-016-1492-4 PMC 바로가기 [Article Type] Research Article
Diminished COX-2/PGE 2 -Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial CellsResearch Article Published on 2016-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] A549 cell A549 cells addition Affect antiviral activity antiviral response Cell cellular chloride coronavirus 229E decrease decreased expression deficiency diminished downstream DPI dysregulated expression G6PD glucose-6-phosphate dehydrogenase homeostasis Impaired Infection Inflammatory response inhibitor MAPK NADPH NADPH oxidase NF-κB occurred oxidative stress PGE Phosphorylation provide reduced reducing Regulation response Signaling subunit susceptibility These data TNF-α transcriptional level Treatment tumor necrosis factor-α up-regulated viral infections viral replication was determined [DOI] 10.1371/journal.pone.0153462 PMC 바로가기 [Article Type] Research Article
Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirusArticle Published on 2016-04-162023-06-14 Journal: Journal of infection and public health [Category] MERS, [키워드] coronavirus MERS-CoV nitazoxanide Treatment [DOI] 10.1016/j.jiph.2016.04.001 PMC 바로가기 [Article Type] Article
Evidence of successful malaria case management policy implementation in Cambodia: results from national ACTwatch outlet surveys캄보디아에서 성공적인 말라리아 사례 관리 정책 시행의 증거: 국가 ACTwatch 아울렛 조사 결과Research Published on 2016-04-082024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Anti-malarial availability Elimination Market share outlet private sector Public supply Treatment [DOI] 10.1186/s12936-016-1200-2 PMC 바로가기 [Article Type] Research
Does Circulating Antibody Play a Role in the Protection of Piglets against Porcine Epidemic Diarrhea Virus?Research Article Published on 2016-04-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 24 hour Administered administration ameliorated Analysis antibody Antibody Response antibody transfer assigned body temperature circulating circulating antibody Clinical signs collected colostrum contribute contributed demonstrated Effect epidemic diarrhea evaluated experiment faster fecal fecal samples group growth IgA IgG Infection infections inoculated intraperitoneally naïve Neonatal PCR PEDV protection provided Randomized real-time reverse transcriptase remained returned role secretory IgA serum antibody suggested Survivability survival TCID tested Treatment virus virus-neutralizing antibody [DOI] 10.1371/journal.pone.0153041 PMC 바로가기 [Article Type] Research Article
Determinants of delay in malaria care-seeking behaviour for children 15 years and under in Bata district, Equatorial Guinea에콰토리얼 기니 바타 지역에서 15세 이하 아동의 말라리아 치료 지연 행동의 결정 요인Research Published on 2016-03-312024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Bata district Care-seeking behaviour Delay Equatorial Guinea malaria Treatment [DOI] 10.1186/s12936-016-1239-0 PMC 바로가기 [Article Type] Research
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease InhibitorResearch Article Published on 2016-03-302022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 3CLpro Animal coronaviruses Antiviral compound antiviral drug antiviral drugs Antiviral treatment cause caused cell tropism contributed coronavirus Coronavirus infection Coronavirus infections Cross-species transmission death disease Diseases effective Efficacy and safety evaluated experimental evidence facilitate fatal disease fatality feature Feline infectious peritonitis Fever full recovery Health Host Human humans immune response Immune-mediated infect inflammatory disease inhibitor Laboratory less lymphopenia mammalian measure Mild Mutation other coronavirus pathogen Pathogenesis progression protease Protease inhibitor recombination rate reduction in Replication reported required respiratory resulting returned reversal risk Significant T cells therapeutic therapeutic efficacy therapeutic strategy tissue Treatment viable treatment viral titer virulence virulent virus virus replication [DOI] 10.1371/journal.ppat.1005531 PMC 바로가기 [Article Type] Research Article
Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease건강 및 면역 매개 질환의 여러 세포 유형에서 eQTL 매핑을 통한 유전자형-표현형 연관성에 대한 통찰력Research Article Published on 2016-03-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Active disease Affect Analysis anti-neutrophil cytoplasmic antibody association Autoimmune Autoimmune diseases blood cell blood vessel blood vessels bowel Cancer cell types cellular cellular activation clinical disease complex complex system contribute cytoplasmic damage database dependent on disease risk disease-associated loci DNA Effect eQTL eQTL analysis eQTL mapping eQTLs estimate examined Examining expression expression data expression quantitative trait loci FIVE Gene Expression Genetic genetic control Genetic studies Genetic variant genetic variants genetics Genome-wide association studies Gut GWAS healthy healthy control healthy controls help Human immune system human inflammatory diseases identifying immune Immune cell immune cell type immune cells immune-mediated diseases in vitro include Infection Inflammation Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory diseases insight investigated joint knowledge leucocyte loci majority mapping Multiple observation Pathogenesis Patient performed proportion PROTECT provide Quantitative regions resulting risk specificity subset subtype tissue tissues Treatment Type variant Vasculitis White blood cell [DOI] 10.1371/journal.pgen.1005908 PMC 바로가기 [Article Type] Research Article
Modeling the transboundary risk of feed ingredients contaminated with porcine epidemic diarrhea virusResearch Article Published on 2016-03-122022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] antimicrobial Beijing carrier China chloride choline condition Control corn diarrhea effective Epidemic epidemic diarrhea evaluate events fatty ingredient inoculated lysine lysine hydrochloride medium methionine modeling organized PEDV plant Porcine representing Result risk risk factor San Francisco Shanghai Soybean meal subset temperature tested Transboundary Transport treated Treatment USA viability virus Vitamin Vitamin D [DOI] 10.1186/s12917-016-0674-z PMC 바로가기 [Article Type] Research Article
Neoehrlichiosis: an emerging tick-borne zoonosis caused by Candidatus Neoehrlichia mikurensisReview Published on 2016-03-012023-06-02 Journal: Experimental & Applied Acarology [Category] 조류인플루엔자, [키워드] Anaplasmataceae Apodemus spp. Candidatus Neoehrlichia mikurenis diagnostics haematological disorders immunodeficiency Ixodes persulcatus Ixodes ricinus Myodes spp. rodents thrombosis Treatment [DOI] 10.1007/s10493-015-9935-y [Article Type] Review