Trends in malaria admissions at the Mbakong Health Centre of the North West Region of Cameroon: a retrospective study카메룬 북서부 지역의 음바콩 보건소에서의 말라리아 입원 추세: 후향적 연구Research Published on 2014-08-222024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Cameroon malaria Mbakong Policy Prevalence Treatment trends [DOI] 10.1186/1475-2875-13-328 PMC 바로가기 [Article Type] Research
FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelinationResearch Published on 2014-08-202022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] Affect Anti-viral immune response approved CD4+ CD8+ T cell Central nervous system clinical disease CNS correlated cytokine production cytolytic Demyelination disease disease severity disease-causing dose drug Effect effective examined exhibited expression flow cytometry food FTY720 IFN-γ infiltration Inflammatory inhibiting Lymph node lymphocyte mice Migration modulate morbidity and mortality Mortality mouse hepatitis virus multiple sclerosis Neuroinflammation neurologic neurotropic not affect occur Patient Post-infection proliferation recorded reduce reduction in Result S1P receptor severity staining T lymphocyte T lymphocytes Therapeutic benefit TNF-α treated Treatment viral replication viral-induced virus virus-specific T cell was determined were infected [DOI] 10.1186/s12974-014-0138-y PMC 바로가기 [Article Type] Research
Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes폐렴구균 모자이크 유전자 내 베타-락탐 내성과 관련된 단일 뉴클레오티드 다형성의 포괄적인 식별Research Article Published on 2014-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] alterations Amino acid analysed antibiotic Antibiotic resistance Antibiotic treatment Antibiotics approach arise association Bacteria Beta-lactam beta-lactam antibiotics block blocks carried cause change children clinical setting collected Comprehensive description determinant determinants Diseases distribution DNA fragment explain Frequency Genetic genetic association genetic determinant genetic determinants Genome Genome sequencing Genome-wide association study genomes Haplotype identification identify INDEL indels independent dataset independent datasets introduced isolate isolates large sample leads lineages loci mechanism Meningitis morbidity morbidity and mortality more difficult mosaic Mutation nasopharyngeal non-susceptibility nucleotide organism performed pneumococcal Pneumonia pneumoniae populations predict Previous studies previous study raise Recombination reported resistance responsible sensitivity sequence single nucleotide Single nucleotide polymorphism single nucleotide polymorphisms SNPs Spread strain Strains Streptococcus pneumoniae susceptible Traditional Treatment understanding USA variant variants while [DOI] 10.1371/journal.pgen.1004547 PMC 바로가기 [Article Type] Research Article
Thiamin supplementation does not reduce the frequency of adverse events after anti-malarial therapy among patients with falciparum malaria in southern Laos티아민 보충제가 남부 라오스의 팔수파럼 말라리아 환자에서 항말라리아 치료 후 부작용 발생 빈도를 줄이지 않는다.Research Published on 2014-07-152024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Laos malaria Plasmodium falciparum thiamin Treatment [DOI] 10.1186/1475-2875-13-275 PMC 바로가기 [Article Type] Research
Reduction of mortality due to tetanus by immunisation and proper wound management of the patients in Sengerema Designated District Hospital, Tanzania탄자니아 센게레마 지정 지구병원에서 환자들의 예방접종 및 적절한 상처 관리로 인한 파상풍으로 인한 사망률 감소journal-article Published on 2014-07-012024-08-18 Journal: Tropical Doctor [Category] 파상풍, [키워드] immunisation Mortality Tetanus Treatment [DOI] 10.1177/0049475514521804 [Article Type] journal-article
Post-varicella angiopathy: a series of 4 patients with focus on virologic and neuroimaging findingsCase Reports Published on 2014-06-012023-06-02 Journal: Pediatric neurology [Category] 두창, [키워드] angiopathy children outcome stroke Treatment varicella zoster [DOI] 10.1016/j.pediatrneurol.2014.01.019 [Article Type] Case Reports
Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome VirusResearch Article Published on 2014-05-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] accompanied accumulating antiviral activity antiviral drug antiviral intervention cellular membrane complex component Compound concerning conserved Coronaviral coronavirus coronavirus 229E Coronavirus infection Coronavirus replication Coronaviruses Culture early phase epithelia genome replication hallmark highly pathogenic Host host cell cytoplasm implicated Including infections inhibit inhibition inhibitor knowledge membrane membrane vesicle membrane-bound membranes MERS-CoV MERS–CoV Middle East mutant Mutation non-structural protein not affected positive potent raise recruitment reduced replicate Replication representing respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus RNA viruses SARS-CoV screened Substitution synthesis target targeting Transcription Treatment viral life cycle viral replication viral RNA synthesis virus virus entry zoonotic [DOI] 10.1371/journal.ppat.1004166 PMC 바로가기 [Article Type] Research Article
Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway리보솜 단백질 돌연변이는 인슐린 경로의 S6 키나제 억제를 통해 자가포식을 유도합니다Research Article Published on 2014-05-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major activated activating Activation affected affecting AKT Anemia antioxidant aplasia autophagy Blood blood cell Blood cells Bone marrow bone marrow failure Catabolism CD34 Cell cellular conserved Critical cytopenia deregulation disease Embryo etiology event example explanation feature Genes growth growth defects Hematopoiesis impair impairment include increase increase in induce inhibit inhibition insulin insulin resistance insulin-signaling pathway involved kinase lead maturation mechanism Mutation observé opens oxygen p53 pathophysiology pathway Pathways Patient patients phenotype Phenotypes Phosphorylation Potential treatment progenitor cell promote provide reactive oxygen species reactive oxygen specy red blood cell red blood cells Red cell red cell aplasia reduce regulated ribosomal protein ribosome ROS RPS19 SDS Shwachman-Diamond syndrome Signaling signaling pathway Treatment triggered Tumor tumor suppressor while zebrafish [DOI] 10.1371/journal.pgen.1004371 PMC 바로가기 [Article Type] Research Article
Identification and genotyping of feline infectious peritonitis-associated single nucleotide polymorphisms in the feline interferon-γ geneResearch Published on 2014-05-212022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] allele amplification analyzed Asymptomatic caused cellular immunity coronavirus correlation Critical decrease effective Factor Feline infectious peritonitis Genotype genotyping heterozygous genotype identification IFN-γ Immune-mediated Infection interferon-γ intron 1 investigated isolates lethal disease morbidity Mutation outcome PCR plasma polymorphism Protective resistant allele Sequencing shown significant decrease Single nucleotide polymorphism SNP the disease thought Treatment Vaccine virulent [DOI] 10.1186/1297-9716-45-57 PMC 바로가기 [Article Type] Research
2012 Update of the 2008 American College of Rheumatology (ACR) Recommendations for the use of Disease-Modifying Anti-Rheumatic Drugs and Biologics in the treatment of Rheumatoid Arthritis (RA)Article Published on 2014-05-202024-09-04 Journal: Arthritis care & research [Category] 대상포진, [키워드] American College of Rheumatology biologics disease-modifying anti-rheumatic drug DMARD recommendations rheumatoid arthritis Treatment [DOI] 10.1002/acr.21641 PMC 바로가기 [Article Type] Article