A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum플라스모듐 팔시파룸(Plasmodium falciparum)에서 변경된 퀴닌 및 퀴니딘 반응에 대한 새로운 후보 유전자로서의 HECT 유비퀴틴-단백질 리가제Research Article Published on 2014-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Altered Analysis antimalarial antimalarial drug Asia association candidate candidate gene changes in chromosome chromosome 13 complex conducted contribute contributing to cross cytotoxic activity defend demonstrated drug Efficacy experiment Factor Factors Genetic genetic screens genetic trait identify IMPROVE initial isolate Laboratory Ligase likelihood locus malaria malaria parasite moderate multiple allele multiple alleles mutated novel occur P. falciparum Plasmodium falciparum preservation progeny Quantitative quantitative trait locus quinidine Quinine response responsiveness segment sensitivity strain subset Surveillance susceptibility These data Treatment treatment failure ubiquitin ligase [DOI] 10.1371/journal.pgen.1004382 PMC 바로가기 [Article Type] Research Article
Interactions between malaria and human immunodeficiency virus anno 2014article Published on 2014-04-302024-09-01 Journal: Clinical Microbiology and Infection [Category] 말라리아, [키워드] clinical epidemiology Diagnosis HIV immunology interactions malaria public health review Treatment [Article Type] article
CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with HypomagnesemiaCNNM2 돌연변이는 저마그네슘혈증 환자의 뇌 발달 장애 및 발작을 유발합니다Research Article Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied Affect Brain brain development brain malformation brain malformations cation channel cause caused Cell cellular clinical variability CNNM2 Combination cRNA cyclin M2 de novo de novo heterozygous missense mutations demonstrated development Diagnosis disease Effect embryonic explain expressing FIVE gene encoding Genetic genetic cause genetic component genetic disease genetic etiology genetic heterogeneity handling HEK293 cell HEK293 cells heterozygous homeostasis human disease hypomagnesemia identify Impaired IMPROVE in vitro activity increase inheritance injection intellectual disability isoform kidney knockdown loss-of-function Magnesium mammalian Mental mental disability mental retardation Missense mutation mutant mutated Mutation neurodevelopmental impairment neurodevelopmental impairments neurological Neurological diseases occur Pathomechanism Pathomechanisms Patient patients with moderate phenotype Phenotypes physiological Physiology Protein reduced Regulation renal rescued Seizure Seizures shown the disease therapeutic drug Treatment TRPM7 unique wild-type zebrafish [DOI] 10.1371/journal.pgen.1004267 PMC 바로가기 [Article Type] Research Article
Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin ( ACTG2 ) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome평활근 액틴(ACTG2) 유전자의 이형 접합체 및 유전 돌연변이는 거대포낭-소결장-장 연동운동부전 증후군의 기초가 됩니다.Research Article Published on 2014-03-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abdominal surgeries abdominal surgery ACTG2 Actin Actins affected affecting arginine arginine residues bladder catheterization codon Cohort cohort of patient component components contractile protein contractile proteins CpG de novo mutation de novo mutations dependent on described description diagnosed dinucleotide disease disorder DNA ENCODE enteric smooth muscle Families Finnish followed by food gastrointestinal problem gastrointestinal problems Genes heterozygous heterozygous mutation Hypoperistalsis identify initial intestinal intestinal pseudo-obstruction intestine less majority megacystis megacystis-microcolon-intestinal hypoperistalsis syndrome microcolon Missense mutation Missense mutations missense variant MMIHS muscle muscle contractile units muscle disease Muscle function Mutation mutations obstruction organ parenteral nutrition Patient patients phenotype powerful tool provide radiologist remained responsible Sanger sequencing Smooth smooth muscle smooth muscle disease Spectrum subjects syndrome the disease total parenteral nutrition Treatment unique urinary catheterization variant visceral whole-exome sequencing γ2 enteric actin [DOI] 10.1371/journal.pgen.1004258 PMC 바로가기 [Article Type] Research Article
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 updateRecommendation Published on 2014-03-252024-09-04 Journal: Annals of the rheumatic diseases [Category] 대상포진, [키워드] DMARDs (biologic) DMARDs (synthetic) Early rheumatoid arthritis rheumatoid arthritis Treatment [DOI] 10.1136/annrheumdis-2013-204573 PMC 바로가기 [Article Type] Recommendation
Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses전사체 메타 분석에 의해 발견된 중추신경계 장애와 암 사이의 역병환에 대한 분자적 증거Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Alzheimer's disease Alzheimer's disease Analysis Author biological processe biological processes cancers Candidates causes CENTRAL CNS CNS disorder Colorectal Comorbidity complex disorders conditions conducted contribute decrease Degradation deregulated deregulation described disease disorder disorders downregulated downregulation driven by Drug repurposing drug treatment drug treatments epidemiological Evidence expected expression Factors Gene Genetic genetic factors Hypothesis incidence inverse lung mechanism Meta-analysis molecular nervous observé opposite overlap Parkinson's Disease pathway Pathways Patient PIN1 Probability progression promote Prostate protective effect Protein related risk Schizophrenia System tested transcriptomic Treatment understanding upregulated upregulation Wnt [DOI] 10.1371/journal.pgen.1004173 PMC 바로가기 [Article Type] Research Article
In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus ReplicationResearch Article Published on 2014-02-202022-10-27 Journal: BioMed Research International [Category] Coronavirus, MERS, [키워드] activity antiviral agent antiviral property binding binding kinetics caused Cell cells Circular coronavirus CrFK current demonstrated different disease effective enteric FIVE Forming Genome helix in vitro Infection inhibit log mutant oligonucleotide peritonitis Region Replication RNA RNAs RT-qPCR significantly target region tested Treatment viral genome virulent virus [DOI] 10.1155/2014/654712 PMC 바로가기 [Article Type] Research Article
Patient-, health worker-, and health facility-level determinants of correct malaria case management at publicly funded health facilities in Malawi: results from a nationally representative health facility survey말라위의 공공 자금 지원 건강 시설에서 올바른 말라리아 사례 관리를 위한 환자, 건강 근로자 및 건강 시설 수준의 결정 요인: 국가적으로 대표적인 건강 시설 조사 결과Research Published on 2014-02-202024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Case management diagnostics malaria Malawi Symptoms Treatment [DOI] 10.1186/1475-2875-13-64 PMC 바로가기 [Article Type] Research
Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside?Research Article Published on 2014-02-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] absence adaptive Adaptive immune response Antigen presentation Antiviral approach BAL Bench Can Cell chemokine compared Consensus control patients coronavirus Critical cytokine decrease determine died different dsRNA early stage enzyme-linked immunosorbent highlight humans IFN IFNα IFNγ IL-12 IL-17 immune response impair in vitro Infected infected patient Infection initial intensive care involved mechanism MERS-CoV MERS-CoV infection Middle East National Occurrence outcome Patient polymerase chain promote respiratory response RNA robust secretion sera supernatant therapeutic approaches Treatment viral dsRNA viruses was performed were used World Health Organization [DOI] 10.1371/journal.pone.0088716 PMC 바로가기 [Article Type] Research Article
Myosins 1 and 6, myosin light chain kinase, actin and microtubules cooperate during antibody-mediated internalisation and trafficking of membrane-expressed viral antigens in feline infectious peritonitis virus infected monocytesResearch Published on 2014-02-122022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] accumulated Actin antibodies Antigen association binding can be used cell lysis complexes coronavirus cortical cytoskeletal experiment Express filaments found Infected infectious inhibiting Intracellular investigated kinase monocyte myosin overcome pathway plasma membranes Protein subsequent Transport transported Treatment Vesicle Viral antigen Viral protein virus [DOI] 10.1186/1297-9716-45-17 PMC 바로가기 [Article Type] Research