In-silico homology assisted identification of inhibitor of RNA binding against 2019-nCoV N-protein (N terminal domain)인-실리코 상동성은 2019-nCoV N-단백질(N 말단 도메인)에 대한 RNA 결합 억제제의 식별을 지원합니다.Article Published on 2021-05-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] 2019 novel corona virus 2019-nCoV approved bind binding binding free energy complex Compound compounds coronavirus CoV docking score drug design drug-likeness free energy homology identify in vitro inhibitor inhibitors molecular molecular dynamics N protein N proteins N Terminal N terminal domain N-protein nCoV novel corona virus NTD nucleocapsid protein pharmacokinetic Protein pyrimidone RNA RNA binding SARS-CoV-2 screened selected Structure target targets the N protein theophylline Virtual screening virus replication [DOI] 10.1080/07391102.2020.1753580 PMC 바로가기 [Article Type] Article
Development of multiplex real-time RT-PCR assay for the detection of SARS-CoV-2SARS-CoV-2 검출을 위한 다중 실시간 RT-PCR 분석법 개발Research Article Published on 2021-04-292022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] 2019-nCoV 96-well plate 96-well plates amplification CDC Chain Reaction Consequences coronavirus SARS-CoV-2 development diagnose diagnostic Diagnostic method false false-negative false-positive result human coronavirus human gene IMPROVE multiplex outbreak PCR method PCR reaction polymerase chain polymerase chain reaction positive protocol provide provided RdRP reaction Real-Time Reverse Transcription Polymerase Chain Reaction real-time RT-PCR Region reverse transcription RNA rRT-PCR SARS-CoV-2 sequence single gene target target mRNA Template Viral viral gene viral genes virus detection was tested [DOI] 10.1371/journal.pone.0250942 PMC 바로가기 [Article Type] Research Article
Therapeutic Potentials of Antiviral Plants Used in Traditional African Medicine With COVID-19 in Focus: A Nigerian PerspectivePharmacology Published on 2021-04-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 2019-nCoV acute respiratory syndrome addition adopted African anti-SARS-CoV-2 Antiviral antiviral drug approach available data carried caused Chinese Combination Community coronavirus coronavirus disease country COVID-19 drug Drug discovery effort Evidence global public health herb-drug interaction herbal immuno-stimulants in silico In vitro assay in vivo experiment increasingly information Interaction Intervention knowledge lethal disease management Medicine non-specific pandemic Phytomedicines plant Potential preventive measures provided recorded reported Research Respiratory disease risk SARS-CoV-2 supportive care TAM Traditional Traditional African Medicine Treatment Vaccines World War II [DOI] 10.3389/fphar.2021.596855 PMC 바로가기 [Article Type] Pharmacology
Single-cell analysis of angiotensin-converting enzyme II expression in human kidneys and bladders reveals a potential route of 2019 novel coronavirus infection인간의 신장과 방광에서 안지오텐신 전환 효소 II 발현의 단일 세포 분석은 2019년 신종 코로나바이러스 감염의 잠재적 경로를 보여줍니다Article Published on 2021-04-202022-09-11 Journal: Chinese medical journal [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infection ACE2 ACE2 expression ACE2 gene Acute kidney injury acute respiratory syndrome addition Analysis angiotensin Angiotensin-converting enzyme bioinformatics bladder Cell cell type cells co-expression coronavirus disease Coronavirus disease 2019 datasets detectable enzyme II epithelial cells evaluate Evidence evidence of expression Fever healthy house human kidney in urine independent Infection intermediate cell kidney kidney damage nCoV Novel coronavirus p value p values Patient Pearson correlation Pearson correlation coefficient provided proximal proximal convoluted tubule proximal tubule recent findings receptor Respiratory complications reveal SAME AS sequencing data Severe acute respiratory syndrome single-cell analysis Single-cell RNA sequencing subtype urinary system Urine virus [DOI] 10.1097/CM9.0000000000001439 PMC 바로가기 [Article Type] Article
Efficacy of cognitive behavioral therapy on mood and quality of life for patients with COVID-19 A protocol for systematic review and meta-analysis인지행동치료가 코로나19 환자의 기분과 삶의 질에 미치는 영향 체계적인 검토 및 메타분석을 위한 프로토콜5000 Published on 2021-04-162022-08-31 Journal: Medicine [Category] COVID-19, MERS, meta-analysis, SARS, [키워드] “COVID-19 2019 coronavirus disease 2019-nCoV behavioral therapy CBT Clinical treatment Cochrane Library cognitive cognitive behavioral therapy cognitive behavioral treatment collaboration conducted Consistency coronavirus coronavirus disease COVID-19 COVID-19 epidemic criteria database Direct Effectiveness eligible Ethical approval Ethics Evidence Guidance include independent Intervention life Meta-analysis mood nCoV OSF outcome Patient patients with COVID-19 patients with COVID19 peer-reviewed protocol Psychological distress psychological health Quality of life registration number reported required resolved review risk of bia Science Science Direct searched Stress systematic review therapy Web of Science [DOI] 10.1097/MD.0000000000025512 PMC 바로가기 [Article Type] 5000
Persistence of SARS-CoV-2 Viral RNA in Nasopharyngeal Swabs after Death: An Observational StudyCommunication Published on 2021-04-102022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 2019-nCoV absence airway antibody Autopsy cause chemiluminescence death Deceased detectable detection diagnosis of SARS-CoV-2 died different time point evaluated IgM/IgG management medico-legal procedures pandemic persistence positive positive individual Post-mortem Real-time PCR RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patient SARS-CoV-2 viral RNA subject Swab Viral load virus was performed [DOI] 10.3390/microorganisms9040800 PMC 바로가기 [Article Type] Communication
First Report on the Latvian SARS-CoV-2 Isolate Genetic DiversityMedicine Published on 2021-04-062022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 2019-nCoV acute respiratory syndrome carried caused China confirmed case coronavirus coronavirus disease Coronavirus-2 country COVID-19 COVID-19 case death Diversity full-length SARS-CoV-2 genetic diversity genome sequence HCoV-19 healthcare Infection isolate Latvia Local Next-generation sequencing outbreak pandemic positive Registered remaining report representing resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates sequenced Sequencing Spread viral isolate WHO [DOI] 10.3389/fmed.2021.626000 PMC 바로가기 [Article Type] Medicine
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19COVID-19에 대한 SARS-CoV-2의 구조적 및 비구조적 단백질과 치료 표적의 역할Review Published on 2021-04-062022-09-11 Journal: Cells [Category] MERS, SARS, 신약개발, 진단, 치료법, [키워드] 2019-nCoV accessory protein accessory proteins ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid angiotensin angiotensin converting enzyme 2 Angiotensin-converting enzyme angiotensin-converting enzyme 2 bats cats causative agent cellular entry cleavage components consequence convalescent plasm Coronaviridae coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 death downstream drugs encapsulate event family focus functional Genome genomic genomic RNA greater gRNA host cell host cell receptor hosts humans Infection lead mammalian MERS MERS-CoV molecular molecular function molecular target myriad non-structural protein Novel coronavirus polymerase polyproteins positive-sense pp1a pp1ab protease proteolytic cleavage RBD Receptor binding domain referred to replicase respiratory resulting RNA genome role S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sgRNAs similarity single-stranded Spike protein spike protein of SARS-CoV-2 Spread ssRNA structural protein structural proteins subgenomic mRNA subgenomic mRNAs synthesis target therapeutic therapy TMPRSS2 translated translation transmembrane transmembrane protease serine 2 undergo Vaccine Variability Viral Viral RNA virus [DOI] 10.3390/cells10040821 PMC 바로가기 [Article Type] Review
Evidence and speculations: vaccines and therapeutic options for COVID-19 pandemic증거 및 추측: COVID-19 전염병에 대한 백신 및 치료 옵션Review Published on 2021-04-032022-09-11 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, 치료제, [키워드] 2019-nCoV accelerate acute respiratory syndrome antiviral therapeutics Characteristics China Committee consequence coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pandemic disease drugs Emergency evaluate Genome global pandemic Health Health Organization highlight human health ICTV mechanisms molecular virology Novel coronavirus protocol Public question recent finding recent findings required respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Side effect Side effects taxonomy the disease therapeutic therapeutic option therapeutic options Transmission Vaccine Vaccine development viruses WHO World Health Organization [DOI] 10.1080/21645515.2020.1824497 PMC 바로가기 [Article Type] Review
Integrated Bioinformatics Analysis for the Screening of Associated Pathways and Therapeutic Drugs in Coronavirus Disease 2019코로나바이러스 질병 2019에서 관련 경로 및 치료 약물의 스크리닝을 위한 통합 생물정보학 분석Article Published on 2021-04-012022-09-11 Journal: Archives of medical research [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] 2019-nCoV 2019-nCoV coronavirus acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis antiviral drug Antiviral effect antiviral effects approved assist bioinformatics Bioinformatics analysis caused Clinical research Clinical treatment clinically conducted contribute coronavirus Coronavirus infection COVID-19 COVID-2019 database disease drug Effects EGCG Epigallocatechin-3-gallate expression functional enrichment Functional enrichment analysis Genes hub genes human coronavirus human protein human proteins ingredient inhibit inhibitor inhibitors Integrated analysis Interaction involved mechanism MERS MERS-CoV N protein network analysis Novel coronavirus PKA Previous studies progression Protein reduce Research resveratrol SARS-CoV-2 SARS-COV-2 infection screened Screening selected significant pathways significantly Stage targets therapeutic targets trans trans-resveratrol transcriptional regulation Treatment Vaccine virus [DOI] 10.1016/j.arcmed.2020.11.009 PMC 바로가기 [Article Type] Article