Specific cytokines in the inflammatory cytokine storm of patients with COVID-19-associated acute respiratory distress syndrome and extrapulmonary multiple-organ dysfunctionResearch Published on 2021-06-042022-10-28 Journal: Virology Journal [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury acute respiratory distress acute respiratory distress syndrome Admission AKI analyzed ARDS ARDS patient coagulation parameter contributed controls correlated COVID-19 COVID-19 patient COVID-19 patients creatinine cytokine Cytokine storm described died Disseminated intravascular coagulation dysfunction healthy volunteer IL-10 IL-6 IL-8 Inflammatory cytokine Inflammatory cytokine storm Laboratory laboratory data multiple organ dysfunction multiple-organ Multiple-organ dysfunction Necrosis negative correlation non-survivor PaO Patient patients with COVID-19 positive correlation recruited relative Result SARS-CoV-2 Serum level significantly Specific Survivors syndrome TNF-α urea nitrogen variable were measured [DOI] 10.1186/s12985-021-01588-y PMC 바로가기 [Article Type] Research
Point of care diagnostic of hypercoagulability and platelet function in COVID-19 induced acute respiratory distress syndrome: a retrospective observational studyResearch Published on 2021-06-022022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] abnormality acute respiratory distress acute respiratory distress syndrome Admission age Algorithm analysed analyzed ARDS bleeding Care Coagulation Coagulopathy Complication complications Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill diagnostic dysfunction elevated higher risk hypercoagulability Hypothesis ICU Impedance aggregometry indicated intensive care longitudinal major bleeding moderate no correlation occurred PaO parameter Patient patients with COVID-19 Platelet POCT Point point of care testing point-of-care respiratory Result retrospective risk severe ARDS single-center the patient therapeutic Thromboelastometry thromboembolic thromboembolic complication Thromboembolic event thrombosis [DOI] 10.1186/s12959-021-00293-8 PMC 바로가기 [Article Type] Research
Transpulmonary pressure measurements and lung mechanics in patients with early ARDS and SARS-CoV-2Observational Study Published on 2021-06-012022-10-05 Journal: Journal of critical care [Category] SARS, 임상, [키워드] acute respiratory distress syndrome acute respiratory syndrome ARDS BMI Boston center Characteristics Chest Chest wall Chest wall mechanics clinical cohorts Compliance coronavirus Coronavirus-2 correlated COVID-19 Critically ill Deaconess demonstrated distress heterogeneity inherent lung lung mechanics Massachusetts Mechanical mechanical ventilation Mechanics moderate-severe Mortality Oxygenation PaO Patient patients with SARS-CoV-2 pleural pressure remained required respiratory Respiratory system SARS-CoV-2 SOFA transpulmonary pressure was collected were measured [DOI] 10.1016/j.jcrc.2021.02.005 PMC 바로가기 [Article Type] Observational Study
The Role of Convalescent Plasma and Tocilizumab in the Management of COVID-19 Infection: A Cohort of 110 Patients from a Tertiary Care Hospital in OmanCOVID-19 감염 관리에서 회복기 혈장과 토실리주맙의 역할: 오만의 3차 치료 병원 환자 110명 코호트Article Published on 2021-06-012022-09-12 Journal: Journal of Epidemiology and Global Health [Category] MERS, SARS, 진단, [키워드] abnormality acute respiratory distress acute respiratory syndrome Admission age chest X-ray conducted convalescent convalescent plasma coronavirus disease-2019 Coronavirus-2 COVID-19 cytokine Cytokine storm effective enrolled Hospitalization Infection Inflammatory inflammatory markers intensive care Laboratory Mortality mortality rate Oman on mechanical ventilation outcome P -value pandemic PaO Patient patients hospitalized randomized clinical trials retrospective cohort study role Safe Sepsis Severe COVID-19 Infection Standard of care syndrome Tertiary the patient therapeutic intervention Tocilizumab Treatment ventilatory parameter [DOI] 10.2991/jegh.k.201222.001 PMC 바로가기 [Article Type] Article
Effects of early corticosteroid use in patients with severe coronavirus disease 2019Research Article Published on 2021-05-312022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] acute respiratory distress administration analyzed baseline characteristics C-reactive protein Characteristics Clinical outcome Coronavirus disease 2019 Corticosteroid corticosteroid treatment Corticosteroids COVID-19 Cycle threshold value demographics Diagnosis discharge disease Effect enrolled Fatality rate hospital Hospital stay in both groups initial no significant difference onset of symptom outcomes PaO Patient Pneumonia reduction in Result retrospective cohort study SARS-CoV-2 Seven severe coronavirus disease severe COVID-19 South Korea syndrome the patient the timing therapeutic agent treated Treatment use of corticosteroid [DOI] 10.1186/s12879-021-06221-5 PMC 바로가기 [Article Type] Research Article
Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumoniaArticle Published on 2021-05-312022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] 95% CI Admission clinical trial Coagulopathy COVID-19 COVID-19 disease death dosage Effect evaluate evaluated female Hospital admission Interaction intubation IQR LMWH low molecular weight median age Mild Moderate COVID-19 PaO Patient patients with COVID-19 Pneumonia primary endpoint Probability progression Prophylactic receiving reduce Respiratory function risk Rome SARS-CoV-2 SARS-COV-2 infection significantly Stage therapeutic translate viral infection [DOI] 10.1038/s41598-021-90713-6 PMC 바로가기 [Article Type] Article
A Machine Learning Approach for Mortality Prediction in COVID-19 Pneumonia: Development and Evaluation of the Piacenza ScoreOriginal Paper Published on 2021-05-312022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] 30-Day mortality 95% CI Accuracy added age Algorithm approach artificial intelligence AUC characteristic Characteristics Classifier Clinical data Clinical outcome Cohort cohorts collected comparable computation Concentration corpuscular hemoglobin COVID-19 data-driven demographics demonstrated develop development effective evaluate exhibited external validation feasible feature Gender Health Italy machine machine learning modeling Mortality mortality risk naïve objective outcomes PaO Patient patient data patients with COVID-19 Physicians Pneumonia predict prediction prognostic score Randomly Result score statistical stroke temperature validation cohort variable was obtained was used website [DOI] 10.2196/29058 PMC 바로가기 [Article Type] Original Paper
Postintubation Decline in Oxygen Saturation Index Predicts Mortality in COVID-19: A Retrospective Pilot StudyResearch Article Published on 2021-05-262022-10-31 Journal: Critical Care Research and Practice [Category] COVID-19, [키워드] acute respiratory distress Acute respiratory failure Analysis ARDS association AUC baseline characteristic condition conducted COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill death Decline enrolled evaluate Future greater hospital index intubation investigated Logistic regression analysis measure mechanically ventilated Mortality Odds ratio outcome oxygen saturation Oxygenation oxygenation index PaO parameters Patient physiological pilot study Pneumonia predict Predictive predictive models Prognostic value receiver operating characteristic Result retrospective SARS-COV-2 infection saturation severity significantly statistically surviving patient surviving patients syndrome variable were recorded [DOI] 10.1155/2021/6682944 PMC 바로가기 [Article Type] Research Article
Randomized clinical trial to evaluate safety and efficacy of convalescent plasma use among hospitalized patients with COVID-19 (PERUCONPLASMA): a structured summary of a study protocol for a randomized controlled trial입원 중인 COVID-19 환자의 회복기 혈장 사용의 안전성과 효능을 평가하기 위한 무작위 임상 시험(PERUCONPLASMA): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-05-172022-09-01 Journal: Trials [Category] SARS, 임상, 진단, 치료기술, [키워드] 1:1 ABO blood type Acute coronary syndrome administration Adverse reaction Adverse reactions aliquot Aliquots All participants allocation anaphylaxis antibody Antigen assessment Bilirubin Blinding block blocks blood gas blood gas analysis blood type C-reactive protein calculated Capacity carried case report form clinical clinical trial clinical trials Coagulation Coma completion confidence level congestive heart failure contraindication control group convalescent plasma coronary syndrome COVID-19 COVID-19 disease COVID-19 pneumonia creatinine Critical Critical disease CRP current D-dimer decrease defined detect Diagnosis dialysis disease Disseminated intravascular coagulation dissemination Donor donors drop Duration Dynamics eCRF Efficacy electronic case report form element eligible enrolled enrolment etiology evaluate evaluated events Evolution exclusion criteria expected experimental group exploratory failure following gas analysis hemodynamic instability hemorrhage hospital hospital discharge Hospitalization Hospitalized hospitalized patient hospitalized patients Hypothesis Hypoxemia ICU IIb in-hospital mortality Inclusion Infarction Inflammatory information Informed consent intensive care intensive care unit Intervention intracranial hemorrhage intravascular coagulation Invasive mechanical ventilation investigator investigators jaundice Laboratory laboratory confirmation Laboratory test Lactate lactate dehydrogenase Length less Local lymphocyte male marker Mechanical mechanical ventilation mmHg molecular Mortality multi-organ failure Myocardial infarction Neutralizing antibodies number objective occur Older open open label outcome oxygen Oxygen requirement oxygen saturation PaO participant Patient performed plasma Platelets Pneumonia power power of 80% previous diagnosis Probability protocol Public Hospital public hospitals quantification randomization Randomized Randomized controlled trial rationale receive reduce reducing reduction Registered resolution of symptom respiratory respiratory rate routine clinical practice Safe Safety Sample size SARS-COV-2 infection score Secondary objectives serious adverse reaction Serious adverse reactions serologic serum serum creatinine severe COVID-19 Severe COVID-19 pneumonia severe disease SOFA specific type standard treatment standard treatment alone statistical analysis Study protocol Stupor subject supplementary material Total total bilirubin transfusion treatment arm Trial uncontrolled vasopressors Ventilation website with COVID-19 [DOI] 10.1186/s13063-021-05189-6 PMC 바로가기 [Article Type] Letter
An Experimental Pre-Post Study on the Efficacy of Respiratory Physiotherapy in Severe Critically III COVID-19 PatientsArticle Published on 2021-05-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI 95%CI baseline change Chest physiotherapy Computed tomography correlation COVID-19 COVID-19 patient Critically ill CT scan described Effect Efficacy evaluate ICU ICU Patients intensive care intensive care unit lung Lung ultrasound management median Oxygenation PaO Patient performed Physiotherapy Quantitative quartile reflected rehabilitation respiratory respiratory physiotherapy Result SARS-CoV-2 severe COVID-19 significant changes in subgroup of patient Volume was performed [DOI] 10.3390/jcm10102139 PMC 바로가기 [Article Type] Article