Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages고도로 제한된 SARS-CoV-2 수용체 발현 및 1차 인간 단핵구 및 단핵구 유래 대식세포에 의한 감염에 대한 내성Article Published on 2022-09-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cause caused cellular cellular receptor condition contribute coronavirus COVID-19 Defense direct infection enzyme Express expression facilitated global pandemic immune activation in vitro Infection involved Macrophage macrophages MDM mechanism monocyte monocyte-derived macrophage Monocyte-derived macrophages Monocytes myeloid cell myeloid cells occur Pathogenesis primary human monocyte priming pseudotyped virions receptor remained resistance to infection SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV2 SARS-CoV2 infection Severe acute respiratory syndrome severity spike subtype the disease TMPRSS2 unlikely unpolarized viral spike [DOI] 10.1002/JLB.4COVA1121-579RR PMC 바로가기 [Article Type] Article
Biomarkers selection for population normalization in SARS-CoV-2 wastewater-based epidemiologyArticle Published on 2022-09-012022-11-15 Journal: Water research [Category] SARS, 바이오마커, [키워드] 5-hydroxyindoleacetic acid acute respiratory syndrome addition approach Biomarker Biomarkers CDC changes in city Community complement Concentration contributing to coronavirus coronavirus disease correlation COVID-19 creatinine Critical demonstrated Dilution distribution epidemiological Epidemiology evaluated FIVE help high accuracy investigated Local metabolite Mild normalized outbreak Paraxanthine plant Population Population biomarker Population normalization Prevalence reported SARS-CoV-2 SARS-CoV2 selected significantly tested the SARS-CoV-2 Treatment utility Variability Viral load viral loads virus Volume Wastewater-based epidemiology [DOI] 10.1016/j.watres.2022.118985 PMC 바로가기
Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines하이드록시프로필-베타-사이클로덱스트린(HP-BCD)은 SARS-CoV-2 복제 및 바이러스 유발 염증성 사이토카인을 억제합니다Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] accompanied ACE2 Affect affected Alter antiviral activity Beta Beta-cyclodextrin Calu Calu-3 Cell cell line cell lines cholesterol COVID-19 COVID-19 disease cyclodextrin Cytokines cytopathic effects demonstrated disease drug Drug repurposing evidenced excipient experimental models expression Human Hyperinflammatory syndrome immunomodulatory effect in vitro in vivo Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibiting investigated microbial products mitigate Monocytes Particles pathophysiology primary human cells Proinflammatory cytokine proinflammatory cytokines protein levels reducing reduction in Replication replication complexes required Respiratory system safety profile SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 selected selective significantly systemic manifestations the disease therapeutic therapeutic agent therapeutic strategy These data treating Treatment viral cytopathic effect virus virus replication virus RNA [DOI] 10.1016/j.antiviral.2022.105373 PMC 바로가기 [Article Type] Article
Follow-up evaluation of patients with liver test abnormalities detected during SARS-CoV2 infectionSARS-CoV2 감염 중 간검사 이상 소견이 발견된 환자에 대한 추적조사Observational Study Published on 2022-09-012022-09-11 Journal: Journal of viral hepatitis [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Abnormalities abnormality Admission antibiotic Blood blood test coronavirus disease Coronavirus disease-19 COVID-19 criteria defined discharge disease during admission evaluated Evolution Factor Fatty liver fatty liver disease ferritin Follow-up Gender immunomodulatory individuals Infection inspired oxygen fraction liver Liver Biopsy Liver function Liver function test liver function tests male metabolic-associated fatty liver disease (MAFLD). Most patient Most patients no correlation Non-invasive observational study outcome oxygen P/F partial pressure Partial pressure of oxygen Patient patients persistent Retrospective analysis SARS-CoV2 SARS-CoV2 infection severity Treatment variable was performed [DOI] 10.1111/jvh.13718 PMC 바로가기 [Article Type] Observational Study
Second round of an interlaboratory comparison of SARS-CoV2 molecular detection assays used by 45 veterinary diagnostic laboratories in the United StatesArticle Published on 2022-09-012022-11-15 Journal: Journal of veterinary diagnostic investigation : o [Category] SARS, 변종, 치료기술, [키워드] addition analyst analytical sensitivity Analytical specificity analyzed assays B.1.1.7 B.1.351 buffer COVID-19 COVID-19 pandemic Critical detect diagnosis of COVID-19 diagnostic evaluate evaluated FDA help humans identify interlaboratory comparison investigation Laboratory limitations marker medium molecular N1 and N2 network nucleocapsid pandemic public health real-time RT-PCR recognize response RNA RT-rtPCR SARS-CoV2 second specificity Support the United State Transport variant variants Viral RNA [DOI] 10.1177/10406387221115702 PMC 바로가기
Trends of thrombo-inflammation biomarkers after Tocilizumab predict treatment failure better than scores in patients with severe SARS-CoV2 related respiratory failureArticle Published on 2022-09-012022-11-15 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Abstract Biomarker CERRAHPASA score COVID-19 Patient predict Prognosis respiratory Respiratory failure SARS-CoV-2 SARS-CoV2 Tocilizumab Treatment trend [DOI] 10.1016/j.ejim.2022.06.004 PMC 바로가기
Genome-wide association study of SARS-CoV-2 infection in Chinese population중국 인구의 SARS-CoV-2 감염에 대한 게놈 차원의 연관성 연구Article Published on 2022-09-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 변종, 진단, [키워드] analyzed ANKRD27 association Asymptomatic carried CD200R1L Chinese close contact conducted coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 severity ERAP1 Exome Genetic genetic association genetic variability Genetic variant genetic variants Genome sequencing Genome-wide association study global public health GWAS heterogeneous individual LINC00700 loci locus MAN1A2 molecular NEIL3 pathogenesis of COVID-19 Patient PCNX2 PLCL2 POLR2A Polymorphisms positive provided recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 Sequencing severity single-nucleotide Single-nucleotide polymorphisms suggested susceptibility symptomatic patient tested therapeutic options ZMAT3 [DOI] 10.1007/s10096-022-04478-5 PMC 바로가기 [Article Type] Article
Making COVID-19 mRNA vaccines accessible: challenges resolvedArticle Published on 2022-09-012023-07-09 Journal: Expert review of vaccines [Category] COVID19(2023년), [키워드] COVID-19 developing countries EMA FDA LDCs LNP mRNA vaccine SARS-CoV2 TRIPS Vaccines WTO [DOI] 10.1080/14760584.2022.2089121
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 항바이러스제의 효능을 평가하기 위한 SCID 마우스 모델Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral drugs antiviral efficacy antivirals B.1.351 B.1.351 variant BALB/c Beta Beta variant binding C57BL/6 CAGE coronavirus Culture drug hamsters Infection infectious virus titer infectious virus titers Infective dose inhibitors intrinsic lack log lung Lung pathology Lungs male mice Model moderate molnupiravir mouse mouse model Mouse models Nirmatrelvir offer Postinfection reagent receptor reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain SARS-CoV2 SCID significantly TCID These data tissue tissue culture twice a day Validity variant variants variants of concern Viral load virus virus strain wild-type [DOI] 10.1128/jvi.00758-22 PMC 바로가기 [Article Type] Article
Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies항균제 내성에 대한 나노바이오틱스: 나노 소재 및 기술의 힘 활용Review Published on 2022-08-122022-09-11 Journal: Journal of Nanobiotechnology [Category] SARS, 유전자 메커니즘, [키워드] Antibiotic resistance Antibiotics anticipated antimicrobial resistance Antimicrobials Bacteria Bacterial Efficacy functional interfere lack mechanism MOST nanomaterials Nanotechnology pandemic Pathogens penetration positioned SARS-CoV2 shape situation spasmodic surface chemistry treat verge [DOI] 10.1186/s12951-022-01573-9 PMC 바로가기 [Article Type] Review