Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactionsSARS-CoV-2 감염의 Shotgun transcriptome, spatial omics 및 등온 프로파일링은 독특한 숙주 반응, 바이러스 다양화 및 약물 상호 작용을 나타냅니다.Article Published on 2021-03-122022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 임상, 진단, 치료기술, 치료제, [키워드] ACE ACE2 expression acute respiratory syndrome addition aldosterone angiotensin applied Autopsy Biomarker Biomarkers caused clade clinical sample clinical samples Computational biology and bioinformatics coronavirus coronavirus 2 COVID-19 disease COVID-19 pandemic COVID-19 patient detect develop diagnostic disease course Diseases drug interaction drugs Evolution feature Gene Expression Genetic help hematological highlight Host host response host responses identify Infection inhibitor interferon isothermal LAMP less loci Lungs Macrophage microbial molecular neutrophil neutrophil infiltration New York City nine outbreak outcomes Pathways Patient patient records Perturbation platform protective effect public health respiratory reveal SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 shotgun significant enrichment specimen Swab tissue tissues Transcriptome transcriptomic data Treatment strategies unique Viral virus yielding [DOI] 10.1038/s41467-021-21361-7 PMC 바로가기 [Article Type] Article
Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?두 폭풍 사이에 혈관 활성 펩타이드 또는 브래디키닌이 COVID-19의 심각성을 뒷받침합니까?Review Published on 2021-03-092022-08-31 Journal: Physiological Reports [Category] 바이오마커, 진단, [키워드] accumulation ACE acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition bradykinin capture cause caused complications contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 cytokine Cytokines develop disease disease severity dysregulated Evidence explain focus Inflammation mechanism microvascular permeability modulation molecular molecular mechanism neprilysin neurolysin neurotensin pandemic pathology Patient peptide peptidergic peptides primary mechanism progression provided respiratory responsible SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Signaling substance P the disease Treatment underlie vascular permeability Vasoactive [DOI] 10.14814/phy2.14796 PMC 바로가기 [Article Type] Review
Antibodies to neutralising epitopes synergistically block the interaction of the receptor‐binding domain of SARS‐CoV‐2 to ACE 2Original Article Published on 2021-03-072022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] ACE ACE‐2 ACE2 African antibody Antibody Response antigenic approach asked B‐cell binding blocked Blood Contact convalescent patient Convalescent patients COVID‐19 defined disease effective enzyme epitope exacerbate Identified identify immune response immunogens immunopathology induce Interaction memory B cells mice neutralising neutralising antibody objective overlapping peptide peptide epitopes peptides plasma Prevent Protein raised RBD receptor‐binding domain receptor‐binding domain reduced risk Region Result safety profile SARS‐CoV‐2 SARS‐CoV‐2‐specific antibody SARS‐CoV‐2 sera significantly South specificity Strains T‐cell responses tested tetramer staining the RBD the Spike the vaccine vaccinate Vaccine Vaccine development [DOI] 10.1002/cti2.1260 PMC 바로가기 [Article Type] Original Article
Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID‐19 diseaseOriginal Article Published on 2021-03-042022-10-29 Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 ADAM17 Ang II angiotensin converting enzyme 2 binding domain BNP cell membranes clinical setting compensated component contribute Control controls correlation COVID‐19 Deleterious disease disease severity distribution downregulated ENhance enzyme expression furin group heart heart failure hearts immunoreactivity increased expression isoform kidney lung male mechanism mRNA level oedema overexpressed Patient plasma Potential proportion pulmonary pulmonary dysfunction RAAS receptor remained renal renal system renal tissue SARS‐CoV‐2 SARS‑CoV2 severity sodium staining surgical susceptibility the disease tissue tissue remodelling TMPRSS2 urinary sodium was increased while [DOI] 10.1111/jcmm.16310 PMC 바로가기 [Article Type] Original Article
Angiotensin-Converting Enzyme (ACE) Inhibitors and Angiotensin Receptor Blockers (ARB) Are Protective Against ICU Admission and Mortality for Patients With COVID-19 DiseaseMedicine Published on 2021-03-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE ACEi ACEi (angiotensin conversing enzyme inhibitor) Admission Against age Analysis angiotensin angiotensin-converting enzyme inhibitor ARB ARB (angiotensin II AT1 receptor blocker) blocker caused checked Clinical data co-morbidity Corona Coronary artery disease coronavirus COVID-19 COVID-19 disease severity COVID-19 infection COVID-19 patient COVID−19 defined diabete diagnosed with COVID-19 disease disease severity Evidence Gender global pandemic greater hospital Hospital admission hypertension ICU ICU admission ICU–intensive care unit information intensive care unit Kuwait medication medications on COVID-19 Mortality Older outcome Patient Primary outcome protective effect respiratory retrieved risk SARS-CoV-2 secondary significantly Support [DOI] 10.3389/fmed.2021.600385 PMC 바로가기 [Article Type] Medicine
Antihypertensive Drugs and COVID-19 Risk: A Cohort Study of 2 Million Hypertensive PatientsObservational Study Published on 2021-03-032022-10-05 Journal: Hypertension (Dallas, Tex. : 1979) [Category] SARS, 임상, [키워드] ACE ACE inhibitor ACE inhibitors angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors antihypertensive ARB ARBs associations blocker calcium channel blockers cardiovascular disease CCB CCBs chronic respiratory disease Cohort coronavirus disease COVID-19 COVID-19 hospitalization database diabetes died drug end point Evidence examined excluded French hazard ratio Hospital stay Hospitalization Hospitalized hypertension hypertensive patient hypothese hypotheses inhibitor insurance Intubated limit lower risk Mortality Patient patients treated pharmacoepidemiology positive prevalent primary end point raise receptor renal risk treated [DOI] 10.1161/HYPERTENSIONAHA.120.16314 PMC 바로가기 [Article Type] Observational Study
The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization studyCOVID-19 감수성 및 중증도에 대한 지오텐신 전환 효소 수치의 영향: 멘델식 무작위 배정 연구Article Published on 2021-03-032022-09-11 Journal: International Journal of Epidemiology [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval ACE ACE gene ACE inhibitor ACE inhibitors Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme. benefit Cohort cohorts COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 severity COVID-19 susceptibility decrease European explain genetic determinant genetic determinants Genetic variant genetic variants Genome-wide association study GWAS Hospitalization Icelanders increase in individual inhibitor initiative Latino mendelian randomization observational studies Odds ratio outcome performed reducing SARS-COV-2 infection Sensitivity analyses serum severe disease severity susceptibility therapy These data Trial variance variant were used [DOI] 10.1093/ije/dyaa229 PMC 바로가기 [Article Type] Article
Effectiveness of an Acute Care for Elders unit at a long-term care facility for frail older patients with COVID-19Observational Study Published on 2021-03-012022-10-05 Journal: Geriatric nursing (New York, N.Y.) [Category] SARS, 임상, [키워드] ACE acute illness addressed Admission Barthel Index Care clinical Cognitive impairment COVID-19 decrease died discharge Effectiveness elder frailty functional Geriatric care had no hospital Hospitalization incidence Long-term care median Older older patient Patient Prevent reduce scale self-care symptomatic transferred with COVID-19 women [DOI] 10.1016/j.gerinurse.2020.10.004 PMC 바로가기 [Article Type] Observational Study
Ethnic and age-specific acute lung injury/acute respiratory distress syndrome risk associated with angiotensin-converting enzyme insertion/deletion polymorphisms, implications for COVID-19: A meta-analysis인종 및 연령별 급성 폐 손상/급성 호흡 곤란 증후군 위험, 안지오텐신 전환 효소 삽입/제거 다형성, COVID-19에 대한 시사점: 메타 분석Meta-Analysis Published on 2021-03-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] 95% CI 95% confidence interval ACE acute lung injury acute respiratory distress syndrome addressed Adults ALI/ARDS allele analyses Analysis angiotensin Angiotensin-converting enzyme ARDS ARDS patient ARDS patients article Asian Asians assessment association associations Bonferroni correction Caucasian Caucasians children CIs Comparisons conducted coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 distress dominant Ethnicity examined genetic model Genotype healthy control healthy controls heterogeneity I/D I/D polymorphism implication include indicated insertion/deletion life lung Lung injury Meta-analysis meta-regression Mortality Odds ratios outcome outlier pandemic Patient patients with COVID-19 polymorphism Polymorphisms Regression reported respiratory distress Respiratory distress syndrome risk robust robustness Significant Statistical power statistically Subgroup analyses subgroup analysis syndrome therapy Topic Treatment was performed [DOI] 10.1016/j.meegid.2020.104682 PMC 바로가기 [Article Type] Meta-Analysis
ACE/ACE2 balance might be instrumental to explain the certain comorbidities leading to severe COVID-19 casesCardiovascular System & Vascular Biology Published on 2021-02-262022-10-28 Journal: Bioscience Reports [Category] COVID-19, MERS, [키워드] ACE ACE/ACE2 ACE2 Angiotensin-converting enzyme Biochemistry Comorbidity cytokine explain host cell hypoxia Infection interferon Lungs mechanism organs outbreak protease raised receptor respiratory SARS-CoV-2 serious complication severe COVID-19 Stage the disease [DOI] 10.1042/BSR20202014 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology