Virology, epidemiology, immunology and vaccine development of SARS-CoV-2, update after nine months of pandemicSARS-CoV-2의 바이러스학, 역학, 면역학 및 백신 개발, 대유행 9개월 만에 업데이트Meeting Report Published on 2021-01-012022-09-01 Journal: Biologicals : journal of the International Associa [Category] SARS, 신약개발, 임상, 진단, [키워드] Alliance antibody Biological Biological Standardization contribute country COVAX COVID-19 dose Epidemiology Highlights IgA immunology Initially International mucosal immune nasal Neutralizing antibodies nine organized pandemic public health emergency Recombination Saliva SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection second wave the vaccine Transmissibility Vaccine Vaccine development Virology virus [DOI] 10.1016/j.biologicals.2020.11.003 PMC 바로가기 [Article Type] Meeting Report
Genetic Diversity and Evolution of the Biological Features of the Pandemic SARS-CoV-2Research Article Published on 2021-01-012022-10-28 Journal: Acta Naturae [Category] COVID-19, [키워드] analyzed approach Biological biological property Characteristics confirmed case contagiousness coronavirus Coronaviruses country COVID-19 death Diversity effort etiological agent Evolution of SARS-CoV-2 exceeded genetic diversity genetic variants Health identify Infection intensive care units New coronavirus nucleotide sequence outbreak pathogenicity Prophylaxis public health measure Retrospective analysis SARS-CoV-2 Sequencing Spread the disease the SARS-CoV-2 therapy understanding viral genome virulence virus Virus evolution [DOI] 10.32607/actanaturae.11337 PMC 바로가기 [Article Type] Research Article
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormonesCOVID-19의 성별 차이: 후보 경로, ACE2의 유전학 및 성 호르몬Review Published on 2021-01-012022-09-11 Journal: American journal of physiology. Heart and circulat [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Activation ADAM17 added angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral response Biological canonical cardiovascular disease caused contribute coronavirus COVID-19 COVID-19 pandemic Critical dependent on disease disease pathogenesis disease severity disintegrin epidemiological data exacerbate female females Gender genetics Health highlight increase in increasingly innate immune response innate immune system involved leads Loss male mechanism membrane metalloproteinase Mortality outcomes Pathways plasma positive positive feedback potential mechanism potential mechanisms protective mechanism proteolytic cleavage RAS receptor Renin renin-angiotensin system SARS epidemic SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection severe disease Sex sex differences sex hormone Sex hormones susceptibility the SARS-CoV-2 Viral viral entry worsened [DOI] 10.1152/ajpheart.00755.2020 PMC 바로가기 [Article Type] Review
Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 PandemicCOVID-19 팬데믹 기간 동안 임산부 및 신생아 SARS-CoV-2 바이러스 부하, Transplacental Antibody Transfer 및 태반 병리 평가Research Published on 2020-12-222022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age Analysis angiotensin angiotensin-converting enzyme 2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody antibody transfer assessment Asymptomatic binding domain biofluids Biological Blood Boston Care Chain Reaction Characteristics cohort study Colocalization Compromised conducted Cord blood coronavirus COVID-19 Critical disease defined detectable disease distribution enrolled enzyme Evidence evidence of exposure expression of SARS-CoV-2 fetoplacental finding Follow-up Immunity implication Importance incidence inefficient Infection Influenza load Massachusetts Maternal maternal plasma measure mechanism Mild Mild disease moderate disease Nasopharyngeal swab Neonatal Neonate Neonates no evidence of nucleocapsid objective occurred outcome participant pathology Placenta placental Placental infection Placentas plasma Point positive pregnancies Pregnancy pregnant women presenting prospective cohort study protective mechanism protective mechanisms provided quantification quantified receptor recruited reduced Relevance respiratory respiratory fluid Result risk robust RT-PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 RNA SARS-CoV-2 viral load Serine setting severe disease significantly lower tertiary care center tested transfer transmembrane serine protease transmembrane serine protease 2 Transmission transmission of SARS-CoV-2 Transplacental transplacental passage umbilical Umbilical cord underlie vertical transmission Viral Viral load Viremia women [DOI] 10.1001/jamanetworkopen.2020.30455 PMC 바로가기 [Article Type] Research
SARS-Cov-2 Interactome with Human Ghost Proteome: A Neglected World Encompassing a Wealth of Biological DataCommunication Published on 2020-12-192022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] addition Affinity purification alternative ORF alternative protein anti-viral response Biological cellular co-immunoprecipitation co-IP COVID-19 outbreak database DMPK Drug repurposing eukaryotic Evidence function functional Ghost ghost protein host cell Human identify initial innate immune response Interaction interactions interactome interactomics involved metabolism missing mRNA ncRNAs Neglected non-coding RNA OpenProt ORF Perspective pharmacokinetic physiological predicted Protein proteome proteomics responsible SARS-CoV-2 target the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic strategies therapeutic targets Therapies thought translated translation Viral protein Viral proteins [DOI] 10.3390/microorganisms8122036 PMC 바로가기 [Article Type] Communication
Evolution Toward Severe Covid-19 From Biological Monitoring to Therapeutic ConsiderationsObservational Study Published on 2020-12-152022-10-04 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, [키워드] Biological C reactive protein COVID-19 Cytokine storm IL-6 monitoring SARS-CoV-2 [DOI] 10.3389/fimmu.2020.562038 PMC 바로가기 [Article Type] Observational Study
Low toxicity and high immunogenicity of an inactivated vaccine candidate against COVID-19 in different animal modelsResearch Article Published on 2020-12-102022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] adjuvants Analysis animal model animal models biochemical analysis Biological characterized clinical trial confirmed case COVID-19 COVID-19 pandemic demonstrated develop DNase effective intervention effective vaccine Health humoral immune response IgG immune persistence immunization immunogenicity inactivated Inactivated vaccine investigated limit Neutralizing antibodies observation performed Phase I preclinical data preclinical study product proportion PROTECT reported Safe SARS-CoV-2 Seroconversion Seven shown Side effects Spread stimulated structural protein tested the disease the vaccine Toxicity Vaccine vaccine candidate virion Virology virus WHO Wuhan [DOI] 10.1080/22221751.2020.1852059 PMC 바로가기 [Article Type] Research Article
Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main proteaseResearch Article Published on 2020-12-032022-10-04 Journal: Heliyon [Category] 신약개발, [키워드] Anti-SARS-CoV-2 Activity ARB ARBs Azilsartan binding affinity binding free energy Biological Biological sciences blocker Blood coagulation carried Chemistry clinical study Combination Compound compounds computer Computer science COVID-19 COVID-19 pandemic COVID-19 virus disease docked docking drug Drug repurposing drugs targeting effective drug Effectiveness eprosartan fibrosis in vitro In vitro studies Inflammation inhibit Irbesartan material Materials science MD MM-GBSA molecular N3 inhibitor nine olmesartan pandemic coronavirus Patient patients worldwide Physics Prevent profiles Prophylactic protease pulmonary fibrosis receptor reduce required SAR SARS-CoV-2 SARS-CoV-2 protease Science telmisartan tested Treatment valsartan vasodilatation VERO E6 cells Virtual screening was performed [DOI] 10.1016/j.heliyon.2020.e05641 PMC 바로가기 [Article Type] Research Article
Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA PolymeraseArticle Published on 2020-11-282022-10-30 Journal: iScience [Category] COVID-19, [키워드] acute respiratory syndrome Analysis ATP Better Biochemistry Biological Biological sciences Biology caused chaperone competing complex coronavirus COVID-19 Efficiency enzyme expression Genome inhibit inhibitor inhibitors kinetic analysis mechanism Molecular biology Molecular Biology Experimental Approach polymerase polymerization provide purification RdRP replicate RNA robust SARS-CoV-2 specificity substrate the SARS-CoV-2 treated [DOI] 10.1016/j.isci.2020.101849 PMC 바로가기 [Article Type] Article
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactionsBioGRID 데이터베이스: 선별된 단백질, 유전 및 화학적 상호작용의 포괄적인 생물의학 자원Tools for Protein Science Published on 2020-11-232022-09-10 Journal: Protein Science : A Publication of the Protein Soc [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome addition annotation BioGRID Biological biological network Biomedical research build can be used captures carried Cas9 cause cell lines cellular chemical interaction Community Complex network Complex networks COVID‐19 COVID‐19 CRISPR CRISPR screen CRISPR Screens curated database dataset datasets disease drug target drugs example experimental evidence extension facilitate generate Genetic genetic interaction genetic interactions genetic screens Health Human include Interaction interactions Modification mouse open organism phenotype post‐translational modification Protein protein interaction Regulation resource respiratory SARS‐CoV‐2 virus Screen Severe acute respiratory syndrome single mutant small molecule Small molecules species specific disease ubiquitin‐proteasome system worm yeast [DOI] 10.1002/pro.3978 PMC 바로가기 [Article Type] Tools for Protein Science