Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapyArticle Published on 2020-11-102022-10-04 Journal: Scientific Reports [Category] 유전자 메커니즘, 치료제, [키워드] acute lung injury affecting Analysis analyzed biopsy Cell cholesterol Clinical management complicate Computational biology and bioinformatics COVID-19 COVID-19 patient Cytokine storm downregulated drug dysregulated EGR1 enrichment analysis Gene Expression gene expression pattern HIF-1 hypoxia impairment lung lung damage lung tissue mapped mechanism Microbiology mitochondrial molecular mechanism molecular networks NDUFA10 NDUFAF5 network nsp5 ORF8 oseltamivir Patient PLAT Protein responses SAMM50 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins Signaling symptomatic Systems biology Therapies therapy thrombosis Transcriptome TTF1 virus [DOI] 10.1038/s41598-020-76404-8 PMC 바로가기 [Article Type] Article
Endomyocardial Biopsy in a Pediatric Patient With Cardiac Manifestations of COVID-19Case Reports Published on 2020-11-012023-07-12 Journal: Circulation. Heart failure [Category] SARS, [키워드] biopsy Cardiomyopathy Child COVID-19 Inflammation [DOI] 10.1161/CIRCHEARTFAILURE.120.007384 PMC 바로가기 [Article Type] Case Reports
A comprehensive review of histopathological findings of infections induced by COVID-19Review Published on 2020-10-312023-07-06 Journal: Cellular and molecular biology (Noisy-le-Grand, France) [Category] SARS, [키워드] biopsy Clinical features COVID-19 Histopathological changes. Pneumonia [Article Type] Review
Brazilian Consortium for the Study on Renal Diseases Associated With COVID-19: A Multicentric Effort to Understand SARS-CoV-2-Related NephropathyMedicine Published on 2020-10-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ADAMTS13 addition analyzed angiotensin-converting enzyme 2 APOL1 appear approach assays association authors Autopsy biopsy Brazil caused CD138 CD20 CD3 CD4 CD57 CD68 CD8 Cell Collapsing glomerulopathy collected complement Complete complex concerning confirmed case coronavirus disease COVID-19 deaths Deceased described detect diagnosed expressing genotyping glomerulopathy help highest IHC include inflammatory cell information involved kidney Kidney disease Kidney injury mechanism Microscopy Morphological morphology motif pathology Patient patients with COVID-19 performed Peripheral blood renal Renal involvement renal tissue respiratory RT-PCR SARS-CoV-2 staining state hospital the patient the United State thrombotic thrombotic microangiopathy tissue university hospital virus with COVID-19 [DOI] 10.3389/fmed.2020.584235 PMC 바로가기 [Article Type] Medicine
Skin Manifestations in COVID-19: Prevalence and Relationship with Disease SeverityArticle Published on 2020-10-122022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Abnormalities Analysis analyzed Barcelona biopsy characteristic Characteristics chilblain clinical cohort of patient collected coronavirus COVID-19 Cutaneous disease exhibited Generalized histology Histopathology hospital ICU admission immunofluorescence immunohistochemistry lesion less lung infiltrate manifestation Other pandemic Patient patients patients with COVID-19 performed radiological relationship SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 significantly skin skin biopsy skin lesions Spain study period systemic symptoms therapeutic [DOI] 10.3390/jcm9103261 PMC 바로가기 [Article Type] Article
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarateArticle Published on 2020-10-022022-10-04 Journal: Nature Communications [Category] MERS, SARS, 신약개발, 진단, 치료제, [키워드] addition agonist agonists airway anti-inflammatory activity antioxidant Antiviral antiviral activity approved biopsy cell lines cellular clinically consequence coronavirus 2 COVID-19 COVID-19 pathology COVID-19 patients cytopathogenic effect decrease disease effective fumarate Gene Expression Herpe host inflammatory response immunology induce Infection Inflammatory responses inhibit inhibitory effect limit mechanism Microbiology Nrf2 pathogenic pathogenic virus pathogenic viruses pathway pro-inflammatory response Replication required respiratory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection suppressed type I interferon vaccinia virus virus replication Zika virus [DOI] 10.1038/s41467-020-18764-3 PMC 바로가기 [Article Type] Article
Assessment of Acute Acral Lesions in a Case Series of Children and Adolescents During the COVID-19 PandemicResearch Published on 2020-09-252022-10-29 Journal: JAMA Dermatology [Category] COVID-19, [키워드] Abnormalities Acral acute respiratory syndrome Adolescent age antibody assessment association biopsy blood test case sery characteristic children Clinical finding conducted coronavirus coronavirus disease COVID-19 COVID-19 pandemic Cutaneous described Diagnosis disease enrolled evaluate Evidence exposure female finding hematologic histologic histologic finding Importance Inflammatory Intervention Laboratory lesion lesions male measure Novel coronavirus objective pandemic participant Pathogenesis Patient patients performed Point Relevance reported Result SARS-CoV-2 SARS-COV-2 infection Sery setting skin Spain Support systemic manifestation tertiary referral hospital the patient university Valencia [DOI] 10.1001/jamadermatol.2020.2340 PMC 바로가기 [Article Type] Research
Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to ImmunothrombosisImmunology Published on 2020-09-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] alveolar injury alveolar lumen alveolar septa biopsy Cell Cell-mediated immunity cells Control COVID 19 COVID-19 diffusion edema Endothelial dysfunction expression Factor Future group Histopathology IL-4 immune responses immunothrombosis Innate immunity interleukin-4 (IL-4) interstitial lung mast cell mast cells (MC) MCs membrane pandemic patients perivascular plasma pneumocyte Pneumonia positive post-mortem lung Prevent recruited SARS-CoV-2 SARS-CoV-2 replication septa septal specimen Spread the cytokine storm Transcription upper airway upregulating [DOI] 10.3389/fimmu.2020.574862 PMC 바로가기 [Article Type] Immunology
Granulomatous inflammation in pulmonary pathology of 2019 novel coronavirus pneumonia: case report with a literature reviewCase Report Published on 2020-09-162022-10-28 Journal: Surgical and Experimental Pathology [Category] COVID-19, [키워드] 2019 novel coronavirus Administered alveolar epithelial cell biopsy bone Breast cancer Case report changes Computed tomography Coronavirus disease 2019 COVID-19 COVID-19 case described desquamation Diagnosis dry cough edema evaluated fatigue Fever fibrosis flow cytometry granulomatous inflammation heterogeneous hospital IMPROVE infecting Infection Inflammation interstitial Laboratory test leukemia literature review lung lung biopsy Lung CT images Lung histopathology images Lungs malignancy manuscript mild inflammatory infiltration organized pandemic Physical examination Pneumonia polymerase chain primary care progression Pulmonary pathology rale reported swab sample Test Throat tomography Tuberculosis upper respiratory tract vascular congestion was performed Wuhan, China [DOI] 10.1186/s42047-020-00071-2 PMC 바로가기 [Article Type] Case Report
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies로피나비르에 대한 임신초기 노출(다루나비르 아님)은 탈락막화를 손상시킵니다: HIV 양성 임신에서 출산 결과가 좋지 않을 수 있는 잠재적 기전Article Published on 2020-08-012022-09-11 Journal: Human reproduction (Oxford, England) [Category] Coronavirus, 비임상, [키워드] Activation Administered Affect age alteration Analysis Angiogenesis animal model Antiretroviral therapy approval Biomarker Biomarkers biopsy birth outcomes breath cART cause caution Cell Cell culture cells chance clinical implications clinical trial clinical trials clinically co-culture Combination complement Complement activation conception contributing to correlation COVID-19 COVID-19 pandemic Culture culture system current darunavir decidualization decrease drug candidate Drug safety dysregulation early pregnancies early pregnancy early stage early stages Effects Efficacy ELISA evaluate evaluated event Evidence evidence of Ex vivo experimental models expression Factor Factors female first trimester flow cytometry for inclusion foundation funding gestational age Health care Health care worker health care workers healthy highest highlight HIV HIV infection HIV protease inhibitor HIV protease inhibitors immune cell population immune cell populations immune dysregulation Immunohistochemical analysis immunohistochemistry impair impairment implication in vitro in vivo include Inflammation initiated lack leads Lopinavir Luminex assay Lye matter maturation mechanism media mice Migration modify mouse natural killer Natural killer cells offered once daily outcome outcomes Participation placental placentation potential mechanism pregnancies Pregnancy pregnant women prophylactically protease PROTECT quantified reduced regimen regulate reported reproductive resource Respiratory disease sacrifice Safe selective specific effect specific effects spiral spiral artery spiral artery remodeling STAT3 Stephen Support supported TANK termination of pregnancy therapeutic potential Think tank tissue transcription factor Transgender Treatment Trial trophoblast trophoblasts uterine uterine natural killer cells. Vascular viability was measured was obtained was used water were used with HIV women [DOI] 10.1093/humrep/deaa151 PMC 바로가기 [Article Type] Article