Novel Synthetic Routes to Prepare Biologically Active Quinoxalines and Their Derivatives: A Synthetic Review for the Last Two Decades생물학적 활성 퀴녹살린 및 그 유도체를 준비하기 위한 새로운 합성 경로: 지난 20년 동안의 종합 검토Review Published on 2021-02-182022-09-10 Journal: Molecules [Category] MERS, 치료제, [키워드] AIDS Antibacterial Antifungal antimicrobial Antiviral approach Bacteria Biological agents biological applications caused cells class compounds derivative derivatives Diseases drug Effect explained focus fungi green chemistry highlight Infectious diseases Last novel pandemic pathogen Pathogens pharmacological quinoxaline Research researchers review route SAR Schizophrenia synthetic therapeutic therapeutic use treat viruses [DOI] 10.3390/molecules26041055 PMC 바로가기 [Article Type] Review
The electrochemical detection of bioterrorism agents: a review of the detection, diagnostics, and implementation of sensors in biosafety programs for Class A bioweaponsReview Article Published on 2021-02-102022-10-04 Journal: Microsystems & Nanoengineering [Category] 진단, [키워드] biosafety biosensors Chemistry class diagnostics disease Electronic properties and materials Government Health implementation instance limit of detection platform shown [DOI] 10.1038/s41378-021-00242-5 PMC 바로가기 [Article Type] Review Article
Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control지리적으로 의존적인 SARS-CoV-2 유전자 적응의 기초가 되는 단일 및 클러스터의 주요 유전 요소 및 약물 및 면역 조절에 대한 결합 친화도에 미치는 영향Article Published on 2021-01-192022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] 변종, 치료제, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 America amino acids analogues analysed antigenicity Asia B cell best binding affinity chymotrypsin Chymotrypsin-like protease circulation class close monitoring Cluster Clustering Clusters Compound Coronavirus-2 country drug drug susceptibility drugs Effectiveness element elements epitope Epitopes Europe evaluate FDA-approved drug FDA-approved drugs Genetic Hierarchical hierarchical clustering highlighting immune inhibitor modulate modulating Mutation Neutralizing antibodies neutralizing antibody occurred Oceania Penciclovir predicted protease purine purine analogue RdRP RdRp inhibitor Recognition reduced Remdesivir RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 sequence SARS-CoV-2 sequences severe acute respiratory syndrome Coronavirus specific mutation specific mutations stability tenofovir the binding affinity Treatment Vaccine Viral Viral proteins Virtual screening was used were assessed [DOI] 10.1093/jac/dkaa444 PMC 바로가기 [Article Type] Article
Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19)입원한 COVID-19 환자의 중증 SARS-CoV-2 감염 예방을 위한 재조합 인간 C1 에스테라제 억제제(conestat alfa): 무작위, 병렬 그룹, 공개 라벨, 다중 센터에 대한 연구 프로토콜의 구조화된 요약 파일럿 시험(PROTECT-COVID-19)Letter Published on 2021-01-042022-09-10 Journal: Trials [Category] 임상, [키워드] 24 hour 24 hours Activation activities acute lung injury addition adjusted Administered administration allergy Antibiotics anticipated anticoagulation arterial Arterial hypertension Basel Blinding BMI Brazil Breast Breast feeding breathing ambient air C-reactive protein C1 esterase inhibitor cardiovascular disease Caregivers changes in Chest Child-Pugh score chronic chronic pulmonary disease chronic renal disease cirrhosis class clinical Clinical improvement clinical trial comparator comparator Patients complement complement system completion conducted Conestat alfa Contact contact activation system contraindication control group Corticosteroids COVID-19 COVID-19 patient CT scan death defined discharge disease disease severity dissemination drug Duration Efficacy and safety element eligibility enrolment evidence of experimental arm family members FIVE followed by history hospital Hospitalization hospitalized patient hypertension ICU IL-6 inhibitor IL-6R improvement Incapacity include inclusion criteria individual Infection inflammatory cascade inflammatory cascades inflammatory proteins inhibitor Interactive Web Response System interim analysis Intravenous injection invasive invasive or non-invasive ventilation investigator-initiated investigators kallikrein kinin system laboratory parameter Liver cirrhosis Local Lung injury mechanical ventilation non-invasive ventilation not blinded number obesity objective Open-label open-label trial Ordinal Scale outcome outcome assessor outcome assessors oxygen oxygen saturation pandemic PaO parallel-group participant Participants Participation Patient performed Pregnancy primary endpoint progression proportion protocol pulmonary disease pulmonary involvement randomised randomization Randomized randomized trial receive recombinant recruited recruitment Registered Remdesivir renal renal disease required risk factor Sample size SARS-COV-2 infection SARS-CoV-2 pandemic scale screened secondary Secondary outcomes severe COVID-19 severe SARS-CoV-2 Standard of care status Study protocol subject supplemental oxygen supplementary material suspicion Switzerland Symptom the SARS-CoV-2 the WHO their family members Tocilizumab Treatment treatment arm Trial Two interim analyses Two interim analysis virological clearance website WHO WHO ordinal scale with COVID-19 X-ray [DOI] 10.1186/s13063-020-04976-x PMC 바로가기 [Article Type] Letter
Coping With COVID-19COVID-19에 대처하기Article Published on 2021-01-042022-08-31 Journal: American journal of clinical pathology [Category] MERS, 치료기술, [키워드] activity affecting caused change changes in class clinical clinical laboratory Clinical pathology conferences coping coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 Department described drastic effort element elements event function functions grand rounds highlighting Laboratory Laboratory medicine Medical student education Medicine outbreak pandemic pathology platform precautions proceed provided real time reported SARS-CoV-2 social distancing state the United State United States University of Washington Washington [DOI] 10.1093/ajcp/aqaa152 PMC 바로가기 [Article Type] Article
Human Leukocyte Antigen (HLA) Class I Susceptible Alleles Against COVID-19 Increase Both Infection and Severity RateInfectious Disease Published on 2020-12-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect Against allele allele frequency Antigen binding calculated class coronavirus correlation correlation coefficient country COVID-19 CTL cytotoxic T lymphocyte cytotoxic t lymphocyte (ctl) death explained had no Haplotype HLA HLA class I HLA-A hla-a/b haplotype HLA-A1 HLA-B HLA-B allele Human increase infected case Infection infection rate less leukocyte linear no correlation Rate reactivity Result SARS-CoV-2 SARS-CoV-2 peptide Severity rate susceptibility susceptible was obtained [DOI] 10.7759/cureus.12239 PMC 바로가기 [Article Type] Infectious Disease
Class I HLA Allele Predicted Restricted Antigenic Coverages for Spike and Nucleocapsid Proteins Are Associated With Deaths Related to COVID-19클래스 I HLA 대립유전자 예측 스파이크 및 뉴클레오캡시드 단백질에 대한 제한된 항원 범위는 COVID-19와 관련된 사망과 관련되어 있습니다Immunology Published on 2020-12-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] addition allele frequency Amino acid analyzed Antigen antigens approach association best Betacoronavirus class Clustering contribute coronavirus coronavirus strains correlated country Coverage COVID-19 death distribution elevated epidemiological data etiological agent frequencies herd immunity HLA HLA allele HLA alleles HLA-A HLA-B Immunity in silico insertion knowledge landscape ligandome lowest mortality rate mortality rates not affect number of deaths outcome Pandemics peptide peptides population coverage analysis potential risk predicted respond Restricted SARS-CoV-2 severity spike Spread spread to the disease These data Vaccine with COVID-19 [DOI] 10.3389/fimmu.2020.565730 PMC 바로가기 [Article Type] Immunology
Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial성인의 중증 COVID-19 치료를 위한 분무형 계면활성제(COV-Surf): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Randomized Controlled Trial Published on 2020-12-102022-09-10 Journal: Trials [Category] MERS, SARS, 비임상, 임상, [키워드] 1080 24 hour 24 hours 48 hour 48 hours ACE2 ADEs administration Adverse adverse event adverse events AEs ALEA All participant All participants allergy alveolar angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anticipated attending physician bind Blinding block randomization Blood bovine breath buffer calcium cells cellular cholesterol Chronic kidney disease class clinical Clinical improvement clinical trial clinical trials Cohort Combination comparator Compliance Concentration conducted Consent contraindication contributing to Control control arm controls COVID-19 COVID-19 adult patient COVID-19 patients current cytokine Data collection Data monitoring committee death declined defined delivery described Device dialysis discretion dissemination dose drug Effect Efficacy EGFR element Eligible participants end point End-Expiratory Pressure Endotracheal intubation enrolled Enrollment enrolment epithelial Escalation EudraCT evaluate exclusion exclusion criteria expected fatty Fatty acid feasibility free fatty acid Frequency hospital hospitalised hypoxia impair include inclusion criteria index Inflammatory marker inflammatory markers Inflammatory response intensive care intensive care unit Intervention investigator Kidney disease lack liver liver failure Local lung lung lavage mechanical ventilation mechanical ventilator mechanically ventilated patient mechanically ventilated patients mixture Mortality nebulisation number objective Open-label opinion Ordinal Scale other treatment outcome oxidative stress Oxygenation PaO participant Patient PCR PEEP Phosphatidylcholine phosphatidylethanolamine phosphatidylglycerol phosphatidylinositol phospholipid PIP Placebo plasma Pneumothorax Positive end-expiratory pressure Prevent Primary outcome progression Protein protocol pulmonary compliance pulmonary hemorrhage pulmonary ventilation quantification randomisation randomised randomised controlled trial Randomized Randomized controlled trial reached receive recorded recruitment reduction Registered reported Respiratory failure SAEs Sample size SARS-CoV-2 viral load SARS-CoV-2 virus secondary outcome Secondary outcomes Serious Adverse Events severe COVID-19 severity sphingomyelin Stage Standard Standard of care status Study protocol subject supplementary material surface tension surfactant synthesis tension the WHO tissue damage total sample size tracheal tracheal aspirate Tracheal aspirates transfer Treatment Trial Trial Steering Committee turnover unique university University College London usual standard of care Ventilation Ventilation Index ventilatory support VFD vibrating mesh nebulizer Viral Viral load virus water website weight with COVID-19 worsening [DOI] 10.1186/s13063-020-04944-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Left Reflects on the Global Pandemic and Speaks to Transform!Article Published on 2020-12-012023-07-11 Journal: Journal of bioethical inquiry [Category] SARS, [키워드] Caste class India Kantian sublime Rohingyas United States [DOI] 10.1007/s11673-020-10064-1 PMC 바로가기
Issues associated with deploying CNN transfer learning to detect COVID-19 from chest X-rays흉부 엑스레이에서 COVID-19를 감지하기 위한 CNN 전이 학습 배포와 관련된 문제Article Published on 2020-12-012022-09-11 Journal: Physical and engineering sciences in medicine [Category] SARS, 치료기술, [키워드] Accuracy Activation Algorithm Analysis applicability can be used chest X-ray Chest X-ray image Chest X-ray images chest X-rays class Class activation maps clinician CNN CNNs confirmed case confirmed cases contributed Convolutional neural network Convolutional neural networks coronavirus COVID-19 Critical database deaths decision deep deep learning detect diagnostic highlight issue lead machine Machine learning algorithms mechanism occurred performed radiologist Radiologists replicate scratch Support technique transfer virus spread Wuhan Wuhan, China X-ray [DOI] 10.1007/s13246-020-00934-8 PMC 바로가기 [Article Type] Article