Experience of the use of hydroxychloroquine on patients with COVID-19: A perspective on viral load and cytokine kineticsCOVID-19 환자에 대한 하이드록시클로로퀸 사용 경험: 바이러스 부하 및 사이토카인 동역학에 대한 관점Article Published on 2021-05-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 치료기술, 치료제, [키워드] active against Anti-inflammatory anti-inflammatory effect Antiviral approved checked Clinical use Complication coronavirus Course COVID-19 COVID-19 diagnosis cytokine cytokine profile detectable disease status Elevation experience HCQ Hydroxychloroquine IL-17 Infection Inflammatory interferon Interferon-gamma interleukin marker Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 MONITOR Patient patients performed Perspective potential therapeutic target preliminary report Prolonged receiving remained respiratory specimen respiratory specimens SARS-CoV-2 SARS-CoV2 specific treatment symptom onset the mean treated Treatment use of hydroxychloroquine Viral load virus [DOI] 10.1016/j.jfma.2020.08.022 PMC 바로가기 [Article Type] Article
Towards computer-aided severity assessment via deep neural networks for geographic and opacity extent scoring of SARS-CoV-2 chest X-raysArticle Published on 2021-04-292022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] acute respiratory syndrome Care Chest chest X-ray Clinical use coronavirus coronavirus disease COVID-19 Critical CXR deep learning Diagnosis effective evaluated experiments feasibility Geographic Lung disease lung involvement Metrics pandemic Patient positive predicted progression radiologist random SARS-CoV-2 scored severity Severity of disease stratified subset Treatment viral infection [DOI] 10.1038/s41598-021-88538-4 PMC 바로가기 [Article Type] Article
The Potency of Seaweed Sulfated Polysaccharides for the Correction of Hemostasis Disorders in COVID-19Review Published on 2021-04-292022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] activities activity Anticoagulant Anticoagulants Antithrombotic Blood coagulation Carrageenans clinical manifestations clinical trial clinical trials Clinical use Combination complementary Compound compounds correction Course COVID-19 COVID-19 associated coagulopathy COVID-19 patient COVID-19 patients death develop disease disorder drug drugs effective Efficacy feature fibrinolytic fibrinolytics fucoidans glycosidic group Hemostasis hemostasis disorders hypercoagulability involved mechanism molecular weight optimal dose oral bioavailability outcome Pathogenesis pathophysiological mechanism potency progression researcher SARS-CoV-2 seaweed seaweed polysaccharides severe COVID-19 sulfated polysaccharide therapeutic potential thrombin inhibitors thrombolytics thrombotic complication Toxicity Treatment ulvans venous [DOI] 10.3390/molecules26092618 PMC 바로가기 [Article Type] Review
Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine StormImmunology Published on 2021-04-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation Against anaphylatoxins Anti-inflammatory autologous bacterial lipopolysaccharide C3a C5a CAR-T cell therapy Clinical use complement complement activation/inhibition complement inhibitors consequence COVID-19 cytokine release Cytokine release syndrome Cytokines differential inhibition EDTA Effect Factor H heat inactivation identify IL-10 IL-12 IL-13 IL-1α IL-1β IL-5 IL-6 IL-7 IL-8 immune immune stimulation impacts in vitro in vitro study inhibition innate immune innate immune system life-threatening LPS marker mononuclear cell PBMC PBMCs Peripheral blood Potential Proinflammatory cytokine Release SC5b-9 secretion serum storm subsequent therapy TNFα utility Viral diseases whole blood assay zymosan [DOI] 10.3389/fimmu.2021.642860 PMC 바로가기 [Article Type] Immunology
Superiority of MALDI-TOF Mass Spectrometry over Real-Time PCR for SARS-CoV-2 RNA DetectionSARS-CoV-2 RNA 검출을 위한 Real-Time PCR보다 MALDI-TOF 질량 분석의 우수성Article Published on 2021-04-222022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] Analysis approved Clinical use COVID-19 demonstrated detection Diagnosis diagnostic diagnostic test discrimination early diagnosis Epidemic Evidence false-negative false-negative results generate gold gold standard mass mass spectrometry Mutation pandemic Panel PCR positive present reported respiratory respiratory infection RT-PCR RT-PCR test SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA sensitivity Spectrometry study group suspected patient Symptom Viral viral genome [DOI] 10.3390/v13050730 PMC 바로가기 [Article Type] Article
Evaluation of a Broad Panel of SARS-CoV-2 Serological Tests for Diagnostic UseArticle Published on 2021-04-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Antigen Clinical use Combination convalescent Corona COVID-19 ECLIA ELISA ELISAs enrolled evaluate IgG immune response Infection less LFA naïve subject neutralization nucleocapsid protein pandemic Panel platform respiratory Result SARS-CoV-2 sensitivity sera serological Serological immune response Serological tests Spike protein Test tested Vaccine-induced immunity [DOI] 10.3390/jcm10081580 PMC 바로가기 [Article Type] Article
MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunityInterpretive Synthesis Review Article Published on 2021-04-082022-10-30 Journal: Immunologic research [Category] COVID-19, [키워드] activated Activation Antiviral Antiviral effect antiviral therapy approach binding cellular receptors Clinical use complex disease COPD COVID-19 develop Diseases domain Drug discovery drug target effort highlight Host host immunity host innate immunity IFN-β immune immune response immune signaling pathway immune signaling pathways increase in Infection Inflammation Inflammatory inflammatory disease inhibitor innate immune responses Innate immunity Intervention intracellular signaling involved IRF Ligand LPS mechanism mice modulation MYD88 offer PAMP pathogen pathway Perspective Phosphorylation Poly I: C Protein Proteins PRR recruitment regulated SEB Sepsis shown Signaling small molecule inhibitor Survivability syndrome targeting Therapeutic approach therapeutic efficacy TLRs treat Type I IFN upregulation viral infection [DOI] 10.1007/s12026-021-09188-2 PMC 바로가기 [Article Type] Interpretive Synthesis Review Article
Tackling Immune Pathogenesis of COVID-19 through Molecular PharmaceuticsPerspective Published on 2021-04-052022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] Anakinra anti-inflammatory agent anti-inflammatory strategy Antiviral benefit clinical study Clinical use Coronavirus disease-19 COVID-19 COVID-19 patients drug Drug discovery Drug interactions effective effective therapy Efficacy immunomodulatory increased risk Infection inflammatory pathway Injury Intervention knowledge Medicines molecular molecular pharmaceutics pandemic pathway Perspective Pharmaceutics Prevent Repurposed drug required Safe tested therapy treat treatment approaches tryptophan metabolites [DOI] 10.3390/pharmaceutics13040494 PMC 바로가기 [Article Type] Perspective
Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main ProteaseArticle Published on 2021-04-022022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] affecting antiviral activity Antiviral compound benefit block Clinical use complementary medicine contribute COVID-19 patients demonstrated global pandemic glycyrrhizin IMPROVE in vitro ingredient inhibit inhibiting Intensive investigated M pro main protease majority mechanism natural outbreak protease Research SARS-CoV-2 SARS-CoV-2 infected individuals SARS-CoV-2 infected patient SARS-CoV-2 replication treat Treatment viral replication [DOI] 10.3390/v13040609 PMC 바로가기 [Article Type] Article
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variantsSARS-CoV-2 및 순환 변이체에 대한 mRNA 백신 유도 항체Article Published on 2021-04-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 antibody arising binding BNT162b2 Cell circulating variant Clinical efficacy Clinical use Cohort Donor E484K elicited epitope Epitopes expressing IgM and IgG individual injection K417N memory B memory B cell memory B cells Moderna monoclonal antibodies monoclonal antibody mRNA mRNA vaccine mRNA vaccines mRNA-1273 Mutation N501Y N501Y mutation natural infection neutralization neutralize Neutralizing activity Pfizer-BioNTech plasma RBD RBD-specific memory B cells receptor response SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein stomatitis tested the vaccine the vaccines titre Vaccine Vaccines variants vesicular stomatitis vesicular stomatitis virus Volunteer volunteers was reduced [DOI] 10.1038/s41586-021-03324-6 PMC 바로가기 [Article Type] Article