Individuals With Weaker Antibody Responses After Booster Immunization Are Prone to Omicron Breakthrough Infections추가 접종 후 항체 반응이 약한 개인은 오미크론 돌발 감염에 걸리기 쉽습니다.Article Published on 2022-06-232022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% confidence interval anti-SARS-CoV-2 IgG antibody Anti-spike anti-spike antibodies anti-spike antibody antibody Antibody titer binding antibody body mass index booster booster vaccination Breakthrough infection breakthrough infections conditions COVID-19 Essen healthcare worker help humoral humoral immune response identify immune independent individual Infection information Level neutralization neutralization capacity occur omicron participant potential risk prone provided response risk routine SARS-CoV-2 SARS-CoV-2 IgG antibody serum sample severe COVID-19 Sex smoking status subject threshold university vaccination vaccination against COVID-19 Vaccine Virus neutralization were measured [DOI] 10.3389/fimmu.2022.907343 PMC 바로가기 [Article Type] Article
IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting Reviews Published on 2022-06-212022-10-05 Journal: Nature reviews. Rheumatology [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] approaches autoinflammatory disease cells characterized clinical feature clinical response clinician conditions diagnostic Diseases disorder dysregulation epidemiological Fever Genotype IL-1 include innate immune innate immune system mechanism mouse model mutant over Pathogenesis pathogenic mutations pathophysiological Patient patients Perspective Phenotypes regulated rheumatologist specific diseases subsequent syndrome systemic inflammation targeted therapy therapeutic targeting therapy [DOI] 10.1038/s41584-022-00797-1 [Article Type] Reviews
Impact of COVID-19 by Pandemic Wave among Patients with Gastroenterology Symptoms in the Emergency Departments at a Medical Center in TaiwanObservational Study Published on 2022-06-202022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] acute gastroenteritis affected baseline bleeding center changes in conditions conducted constipation COVID-19 COVID-19 pandemic Department diagnose Emergency emergency department gastro-intestinal bleeding. gastroenteritis Impact less pandemic recorded retrospective significantly lower Taiwan Wave [DOI] 10.3390/ijerph19127516 PMC 바로가기 [Article Type] Observational Study
Developing Pseudovirus-Based Neutralization Assay against Omicron-Included SARS-CoV-2 Variants오미크론 포함 SARS-CoV-2 변이체에 대한 의사 바이러스 기반 중화 분석 개발Article Published on 2022-06-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antibodies approved backbone Beta biosafety BSL-2 candidate collection time conditions conducted convalescent Convalescent patients convalescent plasma COVID-19 convalescent patient COVID-19 pandemic Developing drugs effective Efficiency expression plasmid full-length Gamma Genome Health HIV HIV-1 immune evasion in vitro luciferase reporter gene monoclonal antibodies neutralization Neutralization assay Neutralizing antibodies neutralizing capacity omicron parameter Particles Plasmid Prevention and control Protein pseudovirus Pseudovirus neutralization assay pseudoviruses reduced REGN10933 REGN10987 reporter gene S protein expression plasmids S309 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spread the S protein therapeutic Vaccine Vaccines variant was tested Wuhan [DOI] 10.3390/v14061332 PMC 바로가기 [Article Type] Article
Clinical characteristics and risk factors for COVID-19 infection and disease severity: A nationwide observational study in EstoniaObservational Study Published on 2022-06-162022-10-04 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI 95%CI ACE2 expression ACE2 receptor affecting age and gender analysed association Cancer Cerebrovascular disease Characteristics clinical cohort study comorbid condition conditions contribute contributed Control Course COVID-19 COVID-19 diagnosis COVID-19 infection COVID-19 pandemic Critical Critical disease database died disease disease course Diseases Estonia expressed Factor Gender Government Health health system hospitalisation identify increased the risk increasing age Infection infection risk intensive care knowledge Liver disease Male sex modulating Myocardial infarction obesity outcome pathogenesis of SARS-CoV-2 positive predict Randomly renal renin-angiotensin system Research risk risk factor risk of infection risk stratification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA selected severe COVID-19 severe COVID-19 disease severe disease severe disease course severity of COVID-19 Sex significantly Sociodemographic Study participants Taking tested Therapies tissues women [DOI] 10.1371/journal.pone.0270192 PMC 바로가기 [Article Type] Observational Study
Clinical Characteristics and Risk Factors for Mortality in Critical Coronavirus Disease 2019 Patients 50 Years of Age or Younger During the Delta Wave: Comparison With Patients > 50 Years in Korea2019년 델타파 중 50세 이하 환자 중대 코로나바이러스 감염증의 임상적 특성 및 사망률 위험인자: 국내 50세 이상 환자와의 비교Article Published on 2022-06-062022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Adult patients age analyses Analysis analyzed Blood stream infection BMI body mass body mass index Case fatality rate clinical Clinical characteristics clinical feature Clinical features condition conditions coronavirus disease Coronavirus disease 2019 COVID-19 creatinine Critical critical condition death Delta delta variant diabetes Diabetes Mellitus died dominant eight electronic medical record enrolled evaluate Factor Fatality rate General population globe highest highlight hospital Hospitalized hypertension identify independent predictor independent predictors Infection measure mechanical ventilation Mortality mortality risk factor mortality risk factors Multivariate analysis nasal nasal cannula Numerous obese obesity Odds ratio Older older patient older patients oxygen Oxygen therapy Patient PCR-confirmed COVID-19 Prevent progression respiratory Respiratory Support risk risk factor Risk factors Secondary infection severity statistically study period study population the patient therapy total patients underlying disease vaccination vaccination rate Vaccinations variant while women Year Young younger patient younger patients [DOI] 10.3346/jkms.2022.37.e175 PMC 바로가기 [Article Type] Article
A Universal Fluorescent Immunochromatography Assay Based on Quantum Dot Nanoparticles for the Rapid Detection of Specific Antibodies against SARS-CoV-2 Nucleocapsid ProteinSARS-CoV-2 뉴클레오캡시드 단백질에 대한 특정 항체의 신속한 검출을 위한 양자점 나노입자 기반 범용 형광 면역크로마토그래피 분석Article Published on 2022-06-022022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody complex Concentration conditions conserved coronavirus coronavirus 2 coupling COVID-19 detection Diagnosis diagnostic Dot expansion expressed Fluorescence fluorescent fluorescent immunochromatography assay Host IgG immunochromatography life cycle limit of detection Mutation rates nanoparticle Ni-NTA nucleocapsid nucleocapsid protein optimization pathogenic point of care point-of-care Point-of-care detection probes Protein protein A purified purity quantum quantum dots Rapid related viruses respiratory respiratory infection SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody serological Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Specific specific antibodies specific antibody specificity Spike protein Spike proteins susceptible Transmission Universal virus viruses was determined Zoonotic coronavirus zoonotic coronaviruses [DOI] 10.3390/ijms23116225 PMC 바로가기 [Article Type] Article
A New Approach to Drug Repurposing with Two-Stage Prediction, Machine Learning, and Unsupervised Clustering of Gene Expression2 단계 예측, 기계 학습 및 유전자 발현의 감독되지 않은 클러스터링으로 약물 용도에 대한 새로운 접근 방식Article Published on 2022-06-012022-08-31 Journal: Omics : a journal of integrative biology [Category] MERS, 신약개발, 유전자 메커니즘, [키워드] Acetate affected alvocidib analyzed approach approximation big data bioinformatics BMS-387032 candidate Candidates characteristic clinical trial clinical trials Cluster Clusters Compound conditions Consistency Control COVID-19 pandemic Critical dermatomyositis develop dimension disease Diseases drug Drug development Drug discovery Drug efficacy Drug repurposing drug research and OMICS effective enrichment enrichment analysis examined expected expression pattern expression patterns followed by for inclusion function functions Gene Expression gene set enrichment analysis Health human diseases identify Inclusion Inclusion body inclusion body myositis Infectious disease Infectious diseases Innovation Intervention machine learning Manifold mitoxantrone myositis New offer pathway phorbol phorbol-12-myristate-13-acetate polymyositis prediction premise Probability projection repurposing Research reversed Reversibility targets Uniform variety vorinostat [DOI] 10.1089/omi.2022.0026 PMC 바로가기 [Article Type] Article
Impact of Gestational COVID-19 on Neonatal Outcomes: Is Vertical Infection Possible?신생아 결과에 대한 임신성 COVID-19의 영향: 수직 감염이 가능합니까?Observational Study Published on 2022-06-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] acute infection analyzed Asymptomatic biological sample Blood breast milk Chain Reaction Characteristics Clinical characteristics Cohort conditions Cord blood Coronavirus-2 COVID-19 demographic demographic and clinical characteristics evaluated Follow-up hospital Impact in urine Infant Infants Infection life maternal blood meconium microbiologically Mild symptom mild symptoms MOST mother Nasopharyngeal swab nasopharyngeal swabs Neonatal Neonatal infection neonatal period Newborn no difference no differences Placenta polymerase chain reaction Pregnancy pregnant women remained reverse transcriptase reverse transcriptase-polymerase chain reaction SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load SARS-CoV2 severe acute respiratory coronavirus Severe acute respiratory coronavirus-2 Spanish susceptibility tested Transmission transmission of SARS-CoV-2 Urine vertical vertical transmission Viral load viral loads women [DOI] 10.1097/INF.0000000000003518 PMC 바로가기 [Article Type] Observational Study
Ursodeoxycholic acid ameliorates cell migration retarded by the SARS-CoV-2 spike protein in BEAS-2B human bronchial epithelial cellsUrsodeoxycholic acid는 BEAS-2B 인간 기관지 상피 세포에서 SARS-CoV-2 스파이크 단백질에 의해 지연된 세포 이동을 개선합니다Article Published on 2022-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression airway analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 basal layer BEAS-2B Beas-2B bronchial epithelial cell BEAS-2B cell Beas-2B cells binding bronchial epithelial cell caused Cell Cell migration cell proliferation cells changes in conditions contribute control cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damage damaged differentiation DNA ENhance enzyme epithelial epithelial cell flow cytometry followed by Gene Expression greater HEK293T Hela immunostaining inhibitory Interaction investigated mechanism Migration overexpression Plasmid Prevent Protective RBD receptor Receptor-binding domain reduced repair repair mechanism Repair mechanisms restoration restored RT-PCR SARS- CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein significantly Single Cell SP binding Spike protein syndrome the receptor-binding domain the SARS-CoV-2 the spike protein transfection Treatment Ursodeoxycholic acid Ursodeoxycholic acid (UDCA). virus infection was increased was measured western blotting wound healing [DOI] 10.1016/j.biopha.2022.113021 PMC 바로가기 [Article Type] Article