Clinical Characteristics and Outcomes of Severe and Critical Patients With 2019 Novel Coronavirus Disease (COVID-19) in Wenzhou: A Retrospective StudyMedicine Published on 2020-09-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 2019 novel coronavirus 28-day mortality Acute cardiac injury Acute kidney injury Acute liver injury ARDS Blood urea nitrogen cardiac chest CT scan clinical Clinical characteristics Confirmed COVID-19 infection consolidation COVID-19 COVID-19 infection Critical Critically ill develop diastolic died disease dysfunction early stage echocardiography ECMO enrolled extracorporeal membrane oxygenation GGO Ground glass opacity hospital Hospitalization increased cardiac output Infection Invasive mechanical ventilation less liver dysfunction lung involvement Manifestations men Mortality Most patient non-invasive ventilation novel Older organ dysfunction outcome Patient Platelet positive Prone position renal replacement therapy retrospective cohort study RT-PCR Severe case severe patients severity suffered treated Ventilation [DOI] 10.3389/fmed.2020.552002 PMC 바로가기 [Article Type] Medicine
Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North AmericaResearch Published on 2020-09-022022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adjusted adopted Analysis analyzed biological significance calculated Case fatality rate caused China Confirmed COVID-19 infection coronavirus disease correlated country COVID-19 death death case diagnostic Europe Fatality rate France GenBank database genomes sequenced genomic sequence Germany GISAID database Impact International Italy lockdown lockdown restriction Lockdown strategy muscle Mutation NC_045512.2 nonsynonymous normalized North America outbreak Pairwise comparison pandemic Patient PCR PCR testing positive proportion public health emergency Rate reported Result SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 reference genome selected Spain Spread Standard testing capacity the spike protein two group US USA viral mutation virus was obtained was performed WHO [DOI] 10.1186/s12967-020-02501-x PMC 바로가기 [Article Type] Research
Hydroxychloroquine plus personal protective equipment versus standard personal protective equipment alone for the prevention of COVID-19 infections among frontline healthcare workers: the HydrOxychloroquine Prophylaxis Evaluation(HOPE) trial: A structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-08-312022-10-29 Journal: Trials [Category] COVID-19, MERS, [키워드] 1:1 absolute reduction addition Administered Admission adverse event adverse events all-cause mortality allocation Arm ARMS assigned assumed baseline Bia breast-feeding China clinical Combination Compliance conducted Confirmed COVID-19 infection Contamination COVID-19 COVID-19 infection Date detect dissemination dose ECG element eligible end point enrolled enrolment evaluate evaluate the effect excluded Follow-up frontline healthcare worker greater HCQ HCW HCWs Health personnel healthcare hospital Hospitalization hospitals Hydroxychloroquine ICU India Infection infection rate initiated intensive care Intervention intervention arm invasive ventilation investigator Italy Laboratory Loading dose medication MONITOR Non-invasive number objective Open-label organ support outcome parallel group participant Patient performed Personal protective equipment PPE pregnant Prevent prevention of COVID-19 Primary outcome proportion protocol provided QT prolongation QTc randomisation randomised randomised controlled trial randomization Randomized controlled trial rate of infection readmission receive reduction Registered registry renal replacement therapy reported Research Sample size Secondary outcomes secure Standard Statistical power status stratified Study protocol Treatment Trial two-sided Vasopressor website [DOI] 10.1186/s13063-020-04679-3 PMC 바로가기 [Article Type] Letter
Hydroxychloroquine for post-exposure prophylaxis of COVID-19 among naval personnel in Sri Lanka: study protocol for a randomized, controlled trialStudy Protocol Published on 2020-08-272022-10-29 Journal: Trials [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Adults carried changed clinical clinical trial Confirmed COVID-19 infection coronavirus Coronavirus 2019 COVID-19 early stage Effectiveness Evidence HCQ healthy Hydroxychloroquine Infection outbreak Patient patients Placebo placebo-controlled polymerase chain post-exposure Prevent Prophylaxis provided public health measure quarantine Randomized Randomized controlled trial randomized, controlled trial rapid increase receive recruitment registry reported rRT-PCR SARS-CoV-2 Spread Sri Lanka Study design Study protocol Symptom test negative Trial unique virus [DOI] 10.1186/s13063-020-04659-7 PMC 바로가기 [Article Type] Study Protocol
The effect of prostacyclin (Iloprost) infusion at a dose of 1 ng/kg/min for 72 hours compared to placebo in mechanically ventilated patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial인공호흡기를 사용하는 COVID-19 환자에서 위약과 비교하여 72시간 동안 1ng/kg/min 용량의 프로스타사이클린(일로프로스트) 주입 효과: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-08-262022-08-13 Journal: Trials [Category] MERS, 임상, [키워드] (Iloprost (normal saline) 1:1 Acute coronary syndrome Adult patient Adult patients age anticipated Biomarker bleeding blinded Blinding block can not Capital Capital Region capture Clinicians comparator concealed conducted Confirmed Confirmed COVID-19 infection Consent coronary syndrome COVID-19 COVID-19 infection COVID-19 patients criteria Day defined Denmark dissemination dose element endothelial endotheliopathy EudraCT exclusion criteria exploratory facilitate FIVE heart failure Hvidovre Hospital hypersensitivity Iloprost intensive care unit intensive care units investigators Local mechanical ventilation mechanically ventilated mechanically ventilated COVID-19 patients mechanically ventilated patient multicenter normal saline number objective outcome parallel group participant Patient patients performed Placebo Pregnancy primary endpoint prostacyclin protocol randomisation randomised Randomized Randomized controlled trial recruitment REDCap Region Sample size sequence statisticians status stratified Study protocol Suspected thrombomodulin total sample size Trial Urine website Withdrawal [DOI] 10.1186/s13063-020-04696-2 PMC 바로가기 [Article Type] Letter
Vitamin D and COVID-19 infection and mortality in UK BiobankShort Communication Published on 2020-08-262022-11-01 Journal: European Journal of Nutrition [Category] COVID-19, MERS, [키워드] 25-hydroxyvitamin D 95% CI Analysis association baseline Blood Concentration Confirmed COVID-19 infection confounder COVID-19 COVID-19 infection COVID-19 mortality Cox proportional hazard death deficiency died Mortality multivariable participant Participants performed Poisson regression Randomised trial reaction recruited regression analysis Result risk serum severe COVID-19 Severe COVID-19 Infection Support UK biobank Vitamin D with COVID-19 [DOI] 10.1007/s00394-020-02372-4 PMC 바로가기 [Article Type] Short Communication
Profile of children with COVID-19 infection: a cross sectional study from North-East NigeriaResearch Published on 2020-08-132022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] age analysed Anosmia Asymptomatic categorical variable Chi square test children children with COVID-19 Clinical characteristics confidence interval Confirmed COVID-19 infection cough COVID-19 cross disease epidemiological evaluate Evidence Fever FIVE IBM infected children infected with COVID-19 Infection involved less loss of taste male Mild moderate disease Nigeria outcome pandemic profile relationship Result RT-PCR shown SPSS state statistical significance Statistics sub-Saharan Africa Symptom symptomatic Symptoms the disease the mean [DOI] 10.11604/pamj.supp.2020.35.145.25350 PMC 바로가기 [Article Type] Research
Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary reportObservational Study Published on 2020-08-012022-10-05 Journal: Journal of AAPOS : the official publication of the [Category] SARS, 임상, [키워드] acute respiratory syndrome Admission Adults Asymptomatic children Clinical course Confirmed COVID-19 infection conjunctival Conjunctival swab coronavirus disease Coronavirus-2 COVID-19 discharge enrolled evaluate gastrointestinal symptoms Hospitalized Infection manifestation Manifestations Mild nasopharyngeal Nasopharyngeal swab ocular Patient patients Pediatric patient performed positive preliminary report Prevalence remained respiratory symptoms SARS-CoV-2 SARS-CoV-2 transmission study cohort Swab swabs symptomatic tested viral presence viral shedding [DOI] 10.1016/j.jaapos.2020.05.002 PMC 바로가기 [Article Type] Observational Study
Liver Injury in COVID-19 Infection: A Systematic ReviewInternal Medicine Published on 2020-07-312022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome appear article articles authors case-control study conducted Confirmed COVID-19 infection coronavirus Course COVID-19 COVID-19 patient COVID-19 patients cross-sectional study death determine elevated liver associated enzymes eligibility criteria eligible Evidence Final FIVE heterogeneity independent Infection initial Injury lft - liver function tests library limitation liver Liver damage liver enzyme liver enzymes Liver injury liver test manual Medicine Medline database Mild Mortality novel coronavirus disease other organs outcome pandemic pathology Patient Prevalence produced progression reported review SARS-CoV-2 screened searched severity of COVID-19 systematic review the disease the patient trajectory was done with COVID-19 [DOI] 10.7759/cureus.9487 PMC 바로가기 [Article Type] Internal Medicine
Comment to: Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infectionLetter to the Editor Published on 2020-07-312022-10-31 Journal: Einstein [Category] COVID-19, MERS, SARS, [키워드] Comment Confirmed COVID-19 infection Patient recommendation Support [DOI] 10.31744/einstein_journal/2020CE5931 PMC 바로가기 [Article Type] Letter to the Editor