Effects of Pandemic Outbreak on Economies: Evidence From Business History ContextPublic Health Published on 2021-03-122022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] business business history CME economies Context coronavirus dysfunction Effect Government history LME economies outbreak pandemic pandemic outbreak reveal the disease [DOI] 10.3389/fpubh.2021.632043 PMC 바로가기 [Article Type] Public Health
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged miceClinical and Translational Article Published on 2021-03-122022-11-01 Journal: Med (New York, N.Y.) [Category] COVID-19, MERS, SARS, [키워드] Abstract Adaptive immune response administration Adults affected aging antibodies Antibody Response approach booster dose caused CD4 CD8 CD8+ T cells Cell cellular ChAdOx1 ChAdOx1 nCoV-19 changes in Clinical outcome Context COVID-19 COVID-19 vaccine COVID-19 vaccines effective effectors elicit ENhance finding follicular funding generate Germinal center Health Humoral immunity IgG and IgM immune response immune system immunogenicity induce Infection influence intramuscular limit magnitude Measures Medicine mice morbidity and mortality Older outcome performed plasma pre-clinical testing protective immunity reduced Regulatory required risk factor robust SARS-CoV-2 SARS-COV-2 infection second dose single dose single vaccination Spread stimulate supported T follicular helper cells Th1 cells vaccination Vaccine vaccine candidate virus-neutralizing antibodies worldwide pandemic [DOI] 10.1016/j.medj.2020.12.006 PMC 바로가기 [Article Type] Clinical and Translational Article
Immunological Characteristics in Type 2 Diabetes Mellitus Among COVID-19 Patients코로나19 환자 중 제2형 당뇨병의 면역학적 특성Observational Study Published on 2021-03-112022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, 임상, [키워드] Admission analyzed CD4 CD8 clinical Concentration Context contribute COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 pneumonia cytokine Cytokines D-dimer declined diabetes Diabetes Mellitus Diabetic diabetic patients dimer disease elevated evaluated feature ferritin flow cytometry groups high mortality Hospitalized hyperglycemia Identifier IL-10 IL-6 IL-8 IL‐6 IL‐8 Imbalance Immune cell immune cells immune system immunological immunological characteristics indicated laboratory parameter Laboratory parameters Lymphocytes lymphopenia Mortality Myoglobin nitrogen NK cell NK cells non-survivor Non-survivors objective participant pathogenic mechanism pathogenic mechanisms patients Pneumonia reduced reduction reductions Registration remained Result Retrospective study Sample serum serum concentrations severity significantly subset survival survivor Survivors T cell T cells T lymphocytes Th1/Th2 ratio TNF‐α Type type 2 diabete type 2 diabetes Type 2 diabetes mellitus urea urea nitrogen were measured [DOI] 10.3389/fendo.2021.596518 PMC 바로가기 [Article Type] Observational Study
International Collaboration to Ensure Equitable Access to Vaccines for COVID‐19: The ACT‐Accelerator and the COVAX FacilityOriginal Scholarship Published on 2021-03-022022-10-29 Journal: The Milbank quarterly [Category] COVID-19, MERS, SARS, [키워드] accelerated access allocation Analysis appear approval benefit Clinical efficacy collaboration Context country COVAX COVID‐19 current dose effective effort Ensure facility finding Government H1N1 pandemic lack limit mechanism pandemic Pandemics pillar Point Policy Prevalence public health Regulatory Research Significant System target the WHO unlikely Vaccine vaccine candidate vaccine candidates Vaccines [DOI] 10.1111/1468-0009.12503 PMC 바로가기 [Article Type] Original Scholarship
A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach신종 전염병의 맥락에서 T-세포 에피토프 발견 및 백신 설계를 가속화하기 위한 프로테옴 전체 면역정보학 도구: 민족 중심 접근Immunology Published on 2021-02-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, [키워드] accelerate Accuracy Analysis AUC build caused CD4+ T-cell CD8+ ChAdOx1 ChAdOx1 vaccine clinical trials comparable complicate Context contribute coronavirus country Coverage COVID-19 pandemic criteria disease distribution effective Emerging infectious disease Emerging infectious diseases emerging-infectious disease Epidemics epitope epitope clusters epitope density epitope discovery epitope mapping Epitope-based vaccine Epitopes Ethnic groups Ethnicity frequencies Frequency genetic polymorphisms geographic distributions glycoprotein HLA HLA allele HLA allele frequencies HLA allele frequency HLA alleles human leukocyte antigen immune response immune responses immune responsiveness immune system immunodominant immunoinformatics in silico Infectious diseases investigated Japanese leukocyte Mortality NetMHCpan optimization Pathogens peptide Phase III clinical trials polymorphism Population predicted protein antigen protein antigens proteome Region retrieved SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-like coronavirus spike glycoprotein T-cell T-cell epitope T-cell epitopes the SARS-CoV-2 utility vaccination Vaccination strategy Vaccinations Vaccine vaccine candidates Vaccine design vaccine-induced immune response vaccine-induced immune responses Variability Variation virus [DOI] 10.3389/fimmu.2021.598778 PMC 바로가기 [Article Type] Immunology
COVID-19 in Ecuador: Imported Control Strategies without Context in a Challenged Healthcare SystemStories from the Field Published on 2021-02-172022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] Coronavirus, SARS, [키워드] Context Control COVID-19 Strategy System [DOI] 10.4269/ajtmh.20-1347 PMC 바로가기 [Article Type] Stories from the Field
Biologic Drugs for Rheumatoid Arthritis in the Context of Biosimilars, Genetics, Epigenetics and COVID-19 Treatment바이오시밀러, 유전학, 후성유전학 및 COVID-19 치료의 맥락에서 류마티스 관절염에 대한 생물학적 약물Review Published on 2021-02-042022-08-31 Journal: Cells [Category] 신약개발, [키워드] achievement addition Affect Arthritis B cell B cells bDMARDs biologic agent biologic agents Biological Biologicals biologics biosimilars Care Context COVID-19 COVID-19 outbreak diagnosing disability DNA methylation drug drugs drugs targeting effective effective therapy Efficacy epigenetics facilitate Factor genetics GM-CSF histone IL-1 IL-6 IMPROVE inhibit life limitation miRNA expression Modification patients Premature Quality of life respond Rheumatoid rheumatoid arthritis rheumatology Safe shown Symptom T cell T cells therapeutic intervention therapy TNF Treatment Usage widespread [DOI] 10.3390/cells10020323 PMC 바로가기 [Article Type] Review
Demand Analysis of a Psychiatric Emergency Room and an Adolescent Acute Inpatient Unit in the Context of the COVID-19 Pandemic in Madrid, SpainPsychiatry Published on 2021-01-272022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] acute inpatient unit adaptive Adolescent average Care changes in Chi-square conducted Contagion Context COVID-19 decrease Demand described dropped Emergency emergency room explained Fisher exact test hospital Hospital stay Hospitalized identify initial Inpatient Mann-Whitney test Measures mental health pandemic Patient performed predominant Psychiatric psychiatry quantitative variables retrospective room Shock Spain SPSS statistical significance thought Treatment unit university variable variables WHO World Health Organization [DOI] 10.3389/fpsyt.2020.557508 PMC 바로가기 [Article Type] Psychiatry
Radiological Thoracic Vertebral Fractures are Highly Prevalent in COVID-19 and Predict Disease Outcomes방사선학적 흉추 골절은 COVID-19에서 매우 만연하고 질병 결과를 예측합니다Article Published on 2021-01-232022-09-11 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] 치료기술, [키워드] affected bone metabolism cardiorespiratory Care Chest chest X-rays Clinical characteristics clinical impact Context Coronary artery Coronary artery disease COVID-19 COVID-19 patient COVID-19 patients disease emergency department Fracture fractures fragility Health Health care hospital Hospitalized hypertension investigated Italy marker mechanical ventilation metabolism Mild moderate Mortality noninvasive Older Osteoporosis outcomes Patient patients performed poor prognosis Prevalence reported required retrospective cohort study risk of COVID-19 San Raffaele Hospital SARS-CoV-2 Thoracic Vertebral vertebral fractures. [DOI] 10.1210/clinem/dgaa738 PMC 바로가기 [Article Type] Article
Is Obesity Policy in England Fit for Purpose? Analysis of Government Strategies and Policies, 1992–2020Original Scholarship Published on 2021-01-192022-10-29 Journal: The Milbank quarterly [Category] Coronavirus, SARS, [키워드] added Adults agency Analysis analyzed applied change children Context COVID‐19 determine effective Effectiveness England Evidence explain finding Government Health Health inequity help impacts implementation individual influence influences Interpretation lack less majority obesity pandemic Point Policy Policymaking Prevalence public health Quantitative reduce reduced Strategy thematic analysis unlikely urgency viability [DOI] 10.1111/1468-0009.12498 PMC 바로가기 [Article Type] Original Scholarship