Early report on the severity of COVID-19 in hematologic patients infected with the SARS-CoV2 omicron variantArticle Published on 2022-10-012022-11-16 Journal: European journal of haematology [Category] COVID19(2023년), SARS, 변종, [키워드] Ageusia Asymptomatic cause caused condition cough COVID-19 Critical death described disease disease severity fatigue Fever hematologic Hematologic diseases heterogeneous high risk host immunity ICU admission immunodeficiency Infection investigated laboratory parameter less majority Mild symptom morbidity and mortality Mortality nucleic acid amplification observation period occurred omicron Omicron variant Oxygen therapy Patient patient cohort patients remained reported reported symptom required SARS-CoV2 SARS-CoV2 infection severity severity of COVID-19 symptoms of COVID-19 variants viral pathogenicity [DOI] 10.1111/ejh.13818 PMC 바로가기
Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor시험관 내 및 생체 내에서 SARS-CoV-2 감염에 대한 선택적 에스트로겐 수용체 조절제의 항바이러스 효능은 진입 억제제로서 바제독시펜 아세테이트를 나타냅니다Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] Acetate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiviral efficacy Bazedoxifene bazedoxifene acetate candidate cholesterol cholesterol distribution citrate clinical Clomifene Clomifene citrate contagious coronavirus Coronaviruses Critical delta variant distribution drugs Effect Efficacy endosome acidification Estrogen estrogen receptor evaluated exhibited expression hamster hamsters human cell lines humans identify in vitro in vivo infect Infection information inhibited inhibitor interleukin-6 offer omicron Omicron variant pathogenic variant penetration Postinfection pseudovirus pseudoviruses pulmonary viral reduced reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection selective selective estrogen receptor modulator severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Tamoxifen toremifene toremifene citrate variant Vero E6 Vero E6 cell VERO E6 cells weight loss [DOI] 10.1002/jmv.27951 PMC 바로가기 [Article Type] Article
An integrated understanding of the evolutionary and structural features of the SARS-CoV-2 spike receptor binding domain (RBD)Article Published on 2022-09-302022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis binding Clustering co-evolution Computational drug conformational flexibility Conventional COVID-19 Critical deep Deep mutation scan develop drug-target druggability Effect Evolution expected exploratory feature Fuzzy C-means clustering highlight impair Interaction machine machine learning molecular dynamic simulation Molecular simulation Mutation network analysis Protein Quantitative RBD Receptor binding domain Region SARS-CoV-2 sequence Sequence space analysis small molecule stability Structure Structure network analysis. the RBD the SARS-CoV-2 turn [DOI] 10.1016/j.ijbiomac.2022.07.022 PMC 바로가기
Increased household transmission and immune escape of the SARS-CoV-2 Omicron compared to Delta variantsArticle Published on 2022-09-292022-11-16 Journal: Nature Communications [Category] SARS, 변종, [키워드] 95% CI Contact Contact tracing Critical Delta delta variant groups growth household contact household transmission Immune escape Increased independent Infection lower risk omicron public health risk SAR SARS-CoV-2 secondary attack rate Spread susceptibility the epidemic the mean the SARS-CoV-2 Transmissibility understanding vaccination variant variants [DOI] 10.1038/s41467-022-33233-9 PMC 바로가기
Projection in genomic analysis: A theoretical basis to rationalize tensor decomposition and principal component analysis as feature selection toolsArticle Published on 2022-09-292022-11-16 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] addition adjusted applied Biomarker Cancer Cluster Conventional COVID-19 Critical data set data sets described differentially expressed gene distribution Drug discovery gaussian distribution Genes genomic identifying kidney null hypothesis P-value PCA principal component analysis projection pursuit Sample size statistical statistical test Tensor These data threshold treated vector [DOI] 10.1371/journal.pone.0275472 PMC 바로가기
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humansArticle Published on 2022-09-292022-11-15 Journal: Clinical and experimental immunology [Category] SARS, 바이오마커, 치료기술, [키워드] antibody Auto-antibodies Autoimmune Biomarker cancer progression Cell chronic inflammation COVID-19 Critical cytosolic enzyme glutathione glutathione S-transferase omega-1 Human Inflammation Inflammatory diseases inflammatory pathway involved marker modulation Patient Potential biomarker rheumatoid arthritis SARS-CoV-2 serum the disease tissue trichinellosis variety [DOI] 10.1093/cei/uxac060 PMC 바로가기
Saliva sample for detection of SARS-CoV-2: A possible alternative for mass testingArticle Published on 2022-09-282022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] Accuracy Analysis analyzed comparable COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 testing Critical demographic diagnostic disease drooling E gene effective Effectiveness female individual male moderate nasal swabs Nasopharyngeal swab nasopharyngeal swab sample Negative predictive value Nigeria outbreak pandemic participant Participants plethora polymerase chain positive presenting provide reducing risk RT-PCR RT-PCR test Saliva saliva sample SARS-CoV-2 SARS-CoV-2 RdRp sensitivity significantly Specificities specimen Swab [DOI] 10.1371/journal.pone.0275201 PMC 바로가기
Characterizing the Spatiotemporal Heterogeneity of the COVID-19 Vaccination LandscapeArticle Published on 2022-09-282022-11-16 Journal: American journal of epidemiology [Category] SARS, 변종, [키워드] acute respiratory syndrome center Cluster Control coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 vaccination Critical data accuracy discrepancy effort exhibit foci growth heterogeneity IMPROVE landscape outcome prevention rising SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 spatiotemporal Spatiotemporal analysis statistically the SARS-CoV-2 the United State The United States These data Transmission United States vaccination variant widespread [DOI] 10.1093/aje/kwac080 PMC 바로가기
COVID-19 Detection on Chest X-ray and CT Scan: A Review of the Top-100 Most Cited PapersArticle Published on 2022-09-262022-11-15 Journal: Sensors (Basel, Switzerland) [Category] SARS, 치료기술, [키워드] Chest chest X-ray Community Computerized tomography COVID-19 COVID-19 pandemic Critical CT scan CXR dataset detect detection distribution evaluate explained Google Scholar help machine learning MOST paper Pattern recognition problem produced Research researcher review Thoracic worldwide pandemic X-ray [DOI] 10.3390/s22197303 PMC 바로가기
CGRP Plasma Levels Correlate with the Clinical Evolution and Prognosis of Hospitalized Acute COVID-19 PatientsArticle Published on 2022-09-262022-11-15 Journal: Viruses [Category] SARS, 바이오마커, [키워드] baseline Biomarker blood sample calcitonin calcitonin gene-related peptide (CGRP) clinical clinical disease Coagulopathy collected correlated correlation COVID-19 Critical diagnosed disease disease severity eligible etiological agent Evolution heterogenous higher risk highlighting Hospitalization Hospitalized hyperinflammation immune modulation In-hospital investigated involved IP10 Italian Laboratory test Level lung majority moderate pandemic pathophysiology Patient peptide performed plasma predicted prospective cohort study pulmonary intravascular coagulopathy. SARS-CoV-2 SARS-CoV-2 patient severe COVID-19 patients severe respiratory failure Stratification Support Vasoactive [DOI] 10.3390/v14102123 PMC 바로가기