Evaluation of the performance of SARS‐CoV‐2 antibody assays for a longitudinal populationbased study of COVID‐19 spread in St. Petersburg, RussiaResearch Article Published on 2021-06-122022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI 95%CI Abbott acute respiratory syndrome antibody antibody assay Antibody test antibody test result Architect AUC binding antibody calculated Characteristics clinical CMIA Concordance coronavirus correlated COVID19 Cutoff diagnostic ELISA gold standard IgG immunoassay Immunoglobulin immunosorbent Local majority measure median time Microneutralization test Microparticle MNA neutralizing antibody participant PCR polymerase chain positive positive individuals positive PCR test receiver operating characteristics robust Russia Saint Petersburg SARS‐CoV‐2 SARSCoV2 SARSCoV2 infection antibody testing sensitivity sera seroepidemiologic study serological shown specificity Spread threshold total antibody Variation virus neutralization test [DOI] 10.1002/jmv.27126 PMC 바로가기 [Article Type] Research Article
Description and Analysis of Cytokine Storm in Registered COVID-19 Clinical Trials: A Systematic ReviewSystematic Review Published on 2021-06-022022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Biomarker Biomarkers Characteristics clinical clinical trial clinical trial registry clinical trials COVID-19 COVID-19 patient COVID-19 patients criteria CRP CRS Cutoff cutoff value Cytokine release syndrome Cytokine storm D-dimer Definition description elevated ferritin Fever high variability hospitalized patient IL-6 Inflammatory biomarker LDH Lymphocyte count medication medications radiologic required review searched storm systematic review Tocilizumab Trial Variability was measured [DOI] 10.3390/pathogens10060692 PMC 바로가기 [Article Type] Systematic Review
Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial60세 이상의 건강한 성인을 대상으로 한 불활성화 SARS-CoV-2 백신(CoronaVac)의 안전성, 내약성 및 면역원성: 무작위, 이중 맹검, 위약 대조, 1/2상 임상 시험Randomized Controlled Trial Published on 2021-06-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] Adults Adverse reaction Adverse reactions age All participants Aluminium aluminium hydroxide antibody Antibody Response Antibody titre assigned baseline Beijing block Block randomisation China Chinese clinical trial CoronaVac COVID-19 COVID-19 vaccine Cutoff defined detectable development dose dose-escalation double-blind eight Endpoint enrolled groups healthy hydroxide immunogenicity inactivated injection injection site pain intervention group Intramuscular injection investigators Laboratory live SARS-CoV-2 Mild moderate morbidity morbidity and mortality Neutralising Antibodies neutralising antibody neutralising antibody titres occurred Older Older adults participant Participants Phase 1 Phase 2 phase 3 trial Placebo placebo group placebo-controlled positive primary immunogenicity Program random assignment randomised Randomly receive Registered reported research and development Safe Safety safety population SARS-CoV-2 SARS-CoV-2 vaccine Science second dose Serious Adverse Events Seroconversion seroconversion rate seronegative seropositive Seven severity technology the disease the placebo group titre Tolerability treatment allocation trial protocol vaccination Vaccine virus [DOI] 10.1016/S1473-3099(20)30987-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
Pandemic Effects and Gluten-Free Diet: An Adherence and Mental Health ProblemArticle Published on 2021-05-272022-10-30 Journal: Nutrients [Category] Coronavirus, SARS, [키워드] adherence affecting Anxiety celiac disease Characteristics clinical condition condition conditions COVID-19 pandemic Cutoff Depression depression score depressive symptom eating Effect gluten-related disorders health condition help IMPROVE index likelihood maintain mandatory measure mental health pandemic participant Participants Person problem proportion questionnaire strongly related Support Treatment [DOI] 10.3390/nu13061822 PMC 바로가기 [Article Type] Article
Psychological Impacts and Post-Traumatic Stress Disorder among People under COVID-19 Quarantine and Isolation: A Global SurveyArticle Published on 2021-05-262022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] adverse effect Asian Buddhist caused contributing to correlation country COVID-19 COVID-19 pandemic cross-sectional Cutoff Evidence Factor females global survey healthcare higher odd higher risk IES-R Impact impact of event-scale individual Infection Isolation Lower Measures mental health morbidity and mortality multicentre pandemic participant Post-traumatic stress disorder psychological Impact PTSD quarantine response significantly shorter survey Symptom symptomatic understanding vocational [DOI] 10.3390/ijerph18115719 PMC 바로가기 [Article Type] Article
Clinical Significance of Plasma D-Dimer in COVID-19 MortalityMedicine Published on 2021-05-252022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI Analysis assist clinical Clinical use clinician Cochrane Library comprehensive analysis coronavirus disease COVID-19 COVID-19 mortality COVID-19 patient cut-off Cutoff D-dimer database independent measurement Meta-analysis Mortality Patient plasma poor prognosis predict Prognosis Sample size SARS-CoV-2 searched Significance Stata statistical analyses stratified Study design subgroup analysis systematic review was used [DOI] 10.3389/fmed.2021.638097 PMC 바로가기 [Article Type] Medicine
Fifth-week immunogenicity and safety of anti-SARS-CoV-2 BNT162b2 vaccine in patients with multiple myeloma and myeloproliferative malignancies on active treatment: preliminary data from a single institution다발성 골수종 및 골수증식성 악성종양 환자에 대한 항SARS-CoV-2 BNT162b2 백신의 5주 면역원성 및 활성 치료에 대한 안전성: 단일 기관의 예비 데이터Clinical Trial Published on 2021-05-172022-08-13 Journal: Journal of Hematology & Oncology [Category] SARS, 임상, 진단, [키워드] anti-cancer treatment anti-CD38 anti-SARS-CoV-2 anti-SARS-CoV-2 IgG approved assumed basal BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine booster Cancer chemiluminescent immunoassay chronic myeloid leukemias Cohort cohorts Committee Concentration Concordance Contagion Control Cutoff daratumumab demonstrated disease dose Endpoint evaluated Evidence family family members FDA first dose Gender geometric mean Geometric mean concentrations geometric mean ratio geometric mean ratios GMC GMCs hematological Hematological malignancy IgG IgG test immunogenic immunogenicity increasing age IRCCS Lazio less leukemia likelihood Linear model logarithm maintain Mann–Whitney test Mask Masks mRNA vaccine Multiple myeloma myeloproliferative malignancies myeloproliferative malignancy myeloproliferative neoplasms neutralization test Neutralizing of BNT162b2 Patient patients plaque Plaque reduction neutralization test positive Preliminary data primary endpoint Protective Quantitative reduce Responder responders response response rates Result risk robust S1/S2 Safety SARS-CoV-2 Serologically Seroprotection rate significantly social distancing Swab swabs Test titers titration Treatment vaccination Vaccination Status was done were excluded [DOI] 10.1186/s13045-021-01090-6 PMC 바로가기 [Article Type] Clinical Trial
A rigorous evaluation of optimal peptide targets for MS-based clinical diagnostics of Coronavirus Disease 2019 (COVID-19)Research Published on 2021-05-102022-11-01 Journal: Clinical Proteomics [Category] COVID-19, [키워드] amplifying Analysis analyzed assays automated bioinformatics Care Cell culture clinical samples collected coronavirus coronavirus 2 COVID-19 COVID-19 infection status Cutoff dataset detect detection Diagnosis diagnosis of SARS-CoV-2 diagnostic diagnostics Evidence global pandemic highest human host in vitro Infection Limits of detection mass spectrometry membrane protein molecular nucleocapsid pandemic Patient peptide Peptide-detection Proteins proteomics quantitation respiratory Result SARS-CoV-2 seeking sequence specificity Spread sudden supplementary material target the SARS-CoV-2 virus upper respiratory tract viral peptide Viral proteome Viral RNA Visualization with COVID-19 Workflows [DOI] 10.1186/s12014-021-09321-1 PMC 바로가기 [Article Type] Research
Interleukin-6, procalcitonin and neutrophil-to-lymphocyte ratio: Potential immune-inflammatory parameters to identify severe and fatal forms of COVID-19인터루킨-6, 프로칼시토닌 및 호중구 대 림프구 비율: COVID-19의 심각하고 치명적인 형태를 식별하기 위한 잠재적인 면역 염증 매개변수Article Published on 2021-05-012022-09-11 Journal: Cytokine [Category] Coronavirus, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis ARDS AUROC Biomarker Blood blood cell blood count blood levels C-reactive protein calculated chemiluminescence complete blood count Corticosteroid corticosteroid treatment COVID-19 COVID-19 pathogenesis COVID-19 patients CRP cut-off value Cutoff cytokine Cytokine storm death demonstrated determine e parameters evaluate Evidence ferritin form groups high accuracy hyper-inflammatory immune response identify IL-6 IL2 receptor IL6 Inflammatory biomarker inflammatory biomarkers Inflammatory marker inflammatory markers interleukin interleukin 6 involved kinetic analysis lymphocyte median Mortality multi-organ failure neutrophil neutrophil count Neutrophil-to-lymphocyte ratio NLR parameter Patient PCT Peripheral blood positively correlated Potential predict Predictive procalcitonin prognostic Prognostic marker Prognostic value progression receptor respiratory distress risk ROC Curve severe forms of COVID-19 severity significantly higher steroid steroid therapy Support syndrome therapy threshold threshold value viral-induced was performed WBC were measured White blood cell white blood cell count [DOI] 10.1016/j.cyto.2021.155428 PMC 바로가기 [Article Type] Article
A pilot double-blind safety and feasibility randomized controlled trial of high-dose intravenous zinc in hospitalized COVID-19 patientsRandomized Controlled Trial Published on 2021-05-012022-10-05 Journal: Journal of medical virology [Category] SARS, 임상, [키워드] Administered appear baseline Concentration COVID-19 COVID-19 patient COVID-19 patients Cutoff Day death deficiency demonstrated double-blind Eligible patients Enrollment evaluate feasibility feasible High-dose hospital discharge hospitalizations hospitalized COVID-19 patient hospitalized patient IIa inhibit intravenous participant Patient patients with COVID-19 per day performed phase pilot study Placebo public health measure Randomized Randomized controlled trial reduced Replication reported Safe SARS-CoV virus Serious Adverse Event serum Side effects Treatment Trial trial protocol with COVID-19 Zinc [DOI] 10.1002/jmv.26895 PMC 바로가기 [Article Type] Randomized Controlled Trial