In Silico Screening and Testing of FDA-Approved Small Molecules to Block SARS-CoV-2 Entry to the Host Cell by Inhibiting Spike Protein Cleavage스파이크 단백질 절단을 억제하여 숙주 세포로의 SARS-CoV-2 진입을 차단하는 FDA 승인 소분자의 실리코 스크리닝 및 테스트Article Published on 2022-05-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료제, [키워드] block COVID-19 pandemic COVID-19 patients decrease demonstrated drug candidate Drug repurposing effective FDA-approved drug FDA-approved drugs host cell in silico in silico screening inhibit inhibiting molecular Molecular modeling molecule Prevent protease Protease activity Proteases protein cleavage reduced regimen S protein S protein cleavage SARS-CoV-2 Screening spike tested Testing Treatment Vaccine viral entry [DOI] 10.3390/v14061129 PMC 바로가기 [Article Type] Article
Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agentsReview Published on 2022-05-212023-07-01 Journal: Drug discovery today [Category] COVID19(2023년), SARS, [키워드] Antiviral cyclophilin A cyclosporin A Debio-025 Drug repurposing [DOI] 10.1016/j.drudis.2022.05.016 PMC 바로가기 [Article Type] Review
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses임상적으로 승인된 약물인 Acriflavine은 SARS-CoV-2 및 기타 베타 코로나바이러스를 억제합니다.Article Published on 2022-05-192022-09-11 Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] ACF acriflavine approved Betacoronavirus betacoronaviruses binding block catalytic caused cellular clinical trial clinical trials clinically Concentration coronavirus COVID-19 COVID-19 pandemic drug Drug repurposing effective effort epithelia Ex vivo human airway human airway epithelia identify in some in vivo inhibit inhibitor limit mice Mortality NMR Outbreaks pandemic Papain-like protease PL(pro) protease Protease inhibitor Research SARS-CoV-2 severe disease structural biology tested Vaccines viral replication [DOI] 10.1016/j.chembiol.2021.11.006 PMC 바로가기 [Article Type] Article
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in miceClofoctol은 SARS-CoV-2 복제를 억제하고 쥐의 폐 병리를 감소시킵니다Article Published on 2022-05-192022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] antiviral activity Bacterial cells Clofoctol Compound compounds COVID-19 patients drug Drug repurposing exhibited exhibiting Gene Expression geographical areas human ACE2 receptor human lung IC50 identify Inflammatory inhibit investigated library Lung pathology mice peak concentration pharmacokinetic Pulmonary pathology reduce reduced Registered Regulatory Respiratory tract infections safety profile SARS-CoV-2 SARS-CoV-2 replication screened Support tested therapeutic Therapeutic treatment These data transgenic mice Treatment treatment of COVID-19 patients Viral load [DOI] 10.1371/journal.ppat.1010498 PMC 바로가기 [Article Type] Article
Jumping from Fragment to Drug via Smart ScaffoldsArticle Published on 2022-05-182023-07-08 Journal: ChemMedChem [Category] COVID19(2023년), [키워드] ACE2 COVID-19 Drug repurposing fragment-based drug discovery NMR SARS-CoV-2 Screening [DOI] 10.1002/cmdc.202200092
D3AI-CoV: a deep learning platform for predicting drug targets and for virtual screening against COVID-19D3AI-CoV: 약물 표적 예측 및 COVID-19에 대한 가상 스크리닝을 위한 딥 러닝 플랫폼Article Published on 2022-05-132022-09-11 Journal: Briefings in Bioinformatics [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] approach AUC characteristic composed Compound computer-aided drug design COVID-19 COVID-19 treatment cycle D3AI-CoV deep learning Drug discovery Drug repurposing Drug screening drug target DrugBank drugs effective drug IMPROVE inactive independent mechanism online tool platform powerful tool Predictive receiver receiver operating characteristic reported target target prediction target protein Treatment Virtual screening web application [DOI] 10.1093/bib/bbac147 PMC 바로가기 [Article Type] Article
Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery SystemsReview Published on 2022-05-092022-10-04 Journal: ACS Biomaterials Science & Engineering [Category] 신약개발, [키워드] Administered allergies approach Autoimmune diseases Cancer Cell COVID-19 delivery Dexamethasone disease Diseases disorders drug drug delivery Drug repurposing Effect elicit healthy hyperglycemia hypertension inhibiting insight nanomaterials ocular organ phosphate polymers provide Research Side effects System tissue tissue engineering treat variety [DOI] 10.1021/acsbiomaterials.2c00026 PMC 바로가기 [Article Type] Review
Immunobiology of tubercle bacilli and prospects of immunomodulatory drugs to tackle tuberculosis (TB) and other non-tubercular mycobacterial infectionsReview Published on 2022-05-012022-10-04 Journal: Immunobiology [Category] 신약개발, [키워드] accelerated addition Anti-inflammatory anti-inflammatory properties antimicrobial resistance antimicrobial resistance (AMR) Carprofen COVID-19 pandemic Critical demonstrated disrupt drug Drug discovery Drug repurposing drugs Host immune evasion immunobiology immunomodulatory drug in vivo Infection Inflammatory response inhibit Interaction lung mechanism Microbiome mycobacterial Mycobacterium tuberculosis Mycobacterium tuberculosis (Mtb) non-steroidal anti-inflammatory drug Non-tubercular mycobacteria (NTM) NSAID NSAIDS pathogen pharmacokinetic proinflammatory repurposing resistance to antibiotics responses risk supress target Treatment Tuberculosis [DOI] 10.1016/j.imbio.2022.152224 PMC 바로가기 [Article Type] Review
Repurposing tetracyclines for acute respiratory distress syndrome (ARDS) and severe COVID-19: a critical discussion of recent publications급성 호흡 곤란 증후군(ARDS) 및 중증 COVID-19에 대한 테트라사이클린 용도 변경: 최근 간행물에 대한 비판적 논의Article Published on 2022-05-012022-09-11 Journal: Expert opinion on investigational drugs [Category] COVID19(2023년), SARS, 신약개발, [키워드] activities acute respiratory distress acute respiratory distress syndrome addition antibiotic antiviral activity approach ARDS Area benefit Combination COVID-19 COVID-19 pandemic COVID-19 patients Critical doxycycline Drug repurposing Effectiveness Efficacy Evidence expert fibrosis immunomodulatory incyclinide inflammatory reaction initial limitation limitations Minocycline overcome pharmacological repurposing respiratory distress Respiratory distress syndrome safety profile SARS-CoV2 scarcity scientific evidence severe COVID-19 shown syndrome Tetracycline tetracyclines therapeutic potential therapy [DOI] 10.1080/13543784.2022.2054325 PMC 바로가기 [Article Type] Article
Drug Repurposing for COVID-19: A Review and a Novel Strategy to Identify New Targets and Potential Drug CandidatesReview Published on 2022-04-232023-07-01 Journal: Molecules [Category] COVID19(2023년), SARS, [키워드] computer-aided drug discovery COVID-19 Drug repurposing SARS-CoV-2 [DOI] 10.3390/molecules27092723 PMC 바로가기 [Article Type] Review