SARS-CoV-2 Spike Protein Vaccine-Induced Immune Imprinting Reduces Nucleocapsid Protein Antibody Response in SARS-CoV-2 InfectionSARS-CoV-2 스파이크 단백질 백신 유도 면역 각인은 SARS-CoV-2 감염에서 뉴클레오캡시드 단백질 항체 반응을 감소시킵니다Article Published on 2022-07-292022-09-11 Journal: Journal of Immunology Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료법, [키워드] anti-N antibodies anti-N antibody antibody Antibody Response Antigen antigenic B cell response COVID-19 pandemic D614G epitope Epitopes HCWs healthcare worker humoral immune immune response Imprinting Infection inhibit IQR mechanism memory memory immune response memory response mRNA vaccine mRNA vaccines N protein nucleocapsid protein OAS pathogen primary antibody Primary infection produced reduce response S protein SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection significantly lower situation spike Spike protein subject the spike protein Vaccine variant Wuhan [DOI] 10.1155/2022/8287087 PMC 바로가기 [Article Type] Article
Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8 + T Cell Response in HLA-A Transgenic MiceSARS-CoV-2의 엑소좀 백신 로딩 T 세포 에피토프 펩티드는 HLA-A 형질전환 마우스에서 강력한 CD8 + T 세포 반응을 유도합니다Article Published on 2022-07-292022-09-11 Journal: International journal of nanomedicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjuvant Administered CD8 control group Coronavirus-2 current elicited epitope epitope peptide Ex vivo exosomal vaccine Exosome Exosomes fold followed by fraction frequencies Frequency fused generate HLA-A human leukocyte antigen human leukocyte antigen-A IFN-γ induce injected intracellular cytokine staining leukocyte mice Modification Neutralizing antibodies neutralizing antibody NMR nuclear nuclear magnetic resonance organ toxicity peak peptide peptides purification purified response robust SARS-CoV-2 SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly subcutaneously T cell T cell response T cell responses T cells the SARS-CoV-2 virus the severe acute respiratory syndrome coronavirus-2. transgenic mice transmission electron microscopy Vaccine vaccine group western blotting wild-type [DOI] 10.2147/IJN.S367494 PMC 바로가기 [Article Type] Article
Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron반복되는 YYDRxG 모티프가 있는 SARS-CoV-2에 대한 인간 항체는 Omicron을 포함한 해당 변이체에 대한 결합 및 중화를 유지합니다.Article Published on 2022-07-292022-09-11 Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, [키워드] antibodies antibody Antibody Response Antibody therapeutics antigenic variant antigenic variants binding CDR H3 conserved epitope facilitate Human Human immune system humoral identify IGHD3-22 immune system motif neutralization neutralize Neutralizing antibodies neutralizing antibody omicron Omicron variant Receptor binding domain respond sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related viruses sequence the antibody response the SARS-CoV-2 Vaccine variant variants of concern [DOI] 10.1038/s42003-022-03700-6 PMC 바로가기 [Article Type] Article
Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including OmicronArticle Published on 2022-07-292022-10-05 Journal: Cell Research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] adaptive antibody benefit Beta binding binding affinity broad-spectrum antiviral caused complex Contact COVID-19 crystal structure Delta ENhance epitope fused fusing Gamma hamster Infection Lambda mice mouse-adapted SARS-CoV-2 Mutation nanobody neutralization activity neutralized omicron Prophylactic prophylactically provide provided Pseudotyped viruses RBD RBD residue resolved SARS-CoV-2 SARS-CoV-2 variant tested the RBD the receptor-binding domain the spike protein therapeutic Treatment variant variants variants of concern wild-type Wuhan [DOI] 10.1038/s41422-022-00700-3 [Article Type] Article
Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variantsSARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan [DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article
Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition억제되지 않은 HIV 감염은 SARS-CoV-2 감염에 대한 T 세포 반응을 손상시키고 T 세포 교차 인식을 폐지합니다Article Published on 2022-07-262022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] abrogate abrogation Beta Beta variant CD4 CD8 correlated COVID-19 disease COVID-19 epidemic Cytometry determine diminishe epitope epitope specificity explain First wave Flow flow cytometry greater highlight HIV HIV infection Human identify immunodominance immunology impair in some individual Infection Inflammation instances mechanism mononuclear cell Mutation peptide peptide pools Peripheral blood PLWH Protein Recognition SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants second wave severe COVID-19 severe COVID-19 disease significantly South Africa specificity Spike protein susceptibility T cell T cell activation T cell response T cell responses the Spike variant was used with HIV [DOI] 10.7554/eLife.78374 PMC 바로가기 [Article Type] Article
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeysArticle Published on 2022-07-252022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] class Combination Complete complex Cryo-electron microscopy Donor epitope Fab Human monoclonal antibody identify in vitro less mAb monoclonal antibody Mutation neutralization neutralize Neutralizing activity omicron other variant Prophylactic reported SARS-CoV-2 SARS-CoV-2 mutant sequence spike epitope tested therapeutic therapy Transmission vaccine-mediated immunity variant [DOI] 10.1038/s41564-022-01198-6 [Article Type] Article
SARS-CoV-2 epitope-specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durabilityCOVID-19 질병 중증도 및 항체 내구성 전반에 걸친 SARS-CoV-2 에피토프 특이적 CD4 + 기억 T 세포 반응Article Published on 2022-07-222022-09-11 Journal: Science Immunology [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive anti-S antibody antibody Antibody Response Antibody responses Boston CD4 Cell cells circulating conducted controls convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity demonstrated disease disease control disease course early disease epitope Epitopes First wave follicular function functions greater histocompatibility complex Hospitalization Immunity individual longitudinal study major histocompatibility complex memory memory T nucleocapsid pandemic peptide Population predict proportion recognizing response SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted severe acute respiratory syndrome Coronavirus subset sustained T cell T cells T cells response T helper USA viral clearance virus [DOI] 10.1126/sciimmunol.abl9464 PMC 바로가기 [Article Type] Article
An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design다중 에피토프 기반 펩타이드(MEBP) 백신 설계에서 에피토프 순서의 역할을 연구하기 위한 in silico 접근법Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility approaches bioinformatics candidate Candidates cellular response country COVID-19 pandemic death rates develop epitope Epitopes experimental protocols experimental validation faster highest humoral immunization immunoinformatics in silico in silico Approach introduced less likelihood limitation methodology MOST MVP overcome pandemic peptide positive predicted predictors Quantitative ranking reported SARS-CoV-2 SARS-CoV-2 variant shown Vaccine vaccine candidate vaccine candidates Vaccine design Vaccine development variant virulent [DOI] 10.1038/s41598-022-16445-3 PMC 바로가기 [Article Type] Article
A broad and potent neutralization epitope in SARS-related coronavirusesSARS 관련 코로나바이러스의 광범위하고 강력한 중화 에피토프Article Published on 2022-07-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.529 benefit conserved conserved epitope coronavirus CR3022 cross-neutralizing cross-neutralizing antibody Effectiveness elicited epitope high potency Interaction NAbs natural infection neutralization neutralize Neutralizing antibodies neutralizing antibody omicron RBS receptor binding site reduced respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related coronavirus SARS-related coronaviruses therapeutic therapeutic antibodies vaccination Vaccine variants variants of concern VOCs X-ray X-ray crystallography [DOI] 10.1073/pnas.2205784119 PMC 바로가기 [Article Type] Article