Endogenous social distancing and its underappreciated impact on the epidemic curveArticle Published on 2021-02-042022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] Care change Computational science Contact dependent on Diseases driven by effective endogenous Epidemic epidemiological estimate Evidence Health status healthy healthy individual IMPROVE infecting Influenza Interaction intrinsically lockdown policy mitigate occur Other pandemic parameter predict quarantine reduce reduction severity of symptoms sick social distancing Statistical physics, thermodynamics and nonlinear dynamics the epidemic [DOI] 10.1038/s41598-021-82770-8 PMC 바로가기 [Article Type] Article
Investigational Treatments for COVID-19 may Increase Ventricular Arrhythmia Risk Through Drug InteractionsCOVID-19에 대한 조사 치료는 약물 상호 작용을 통해 심실 부정맥 위험을 증가시킬 수 있습니다Article Published on 2021-02-012022-09-11 Journal: CPT: pharmacometrics & systems pharmacology [Category] 치료제, [키워드] action potential Analysis Arrhythmias Azithromycin cardiac adverse event cardiac adverse events cardiac electrophysiology caused cellular Chloroquine Combination combination therapy coronavirus disease Coronavirus disease 2019 COVID-19 disease drug drug combination drug combinations Drug interactions drugs Effect Factor greater healthy individual healthy individuals heart disease heart failure increase Isolation lead Lopinavir mathematical men molecular Myocyte Patient patient group pharmacokinetics potential benefits predict predicted QT prolongation Quantitative reported risk Ritonavir Sex Simulation statistical analysis susceptible Therapies treat Treatment ventricular ventricular arrhythmias women [DOI] 10.1002/psp4.12573 PMC 바로가기 [Article Type] Article
An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium statusObservational Study Published on 2021-02-012022-10-05 Journal: Nutrition (Burbank, Los Angeles County, Calif.) [Category] SARS, 임상, [키워드] acute respiratory syndrome affected analyzed Blood Confirmed COVID-19 infection Control control group Coronavirus-2 COVID-19 Critical Effect exploratory study Health healthy individual immune response Immune status in healthy individual India individuals Infection Inflammation Micronutrient Non-survivors nutrition pandemic Patient patients with COVID-19 reducing reported Research SARS-CoV-2 Selenium Selenium status Serum level significantly lower statistically significant survival viral infection virus [DOI] 10.1016/j.nut.2020.111053 PMC 바로가기 [Article Type] Observational Study
Antibody dynamics to SARS-CoV-2 in asymptomatic COVID-19 infections무증상 COVID-19 감염에서 SARS-CoV-2에 대한 항체 역학Article Published on 2021-02-012022-09-12 Journal: Allergy [Category] MERS, SARS, 진단, [키워드] analyzed antibodies antibody Antibody dynamics Asymptomatic Asymptomatic carrier Asymptomatic COVID-19 asymptomatic individual asymptomatic infections Biomarker Combination condition controls COVID-19 demonstrated Detection sensitivity Diagnosis diagnostic did not produce dynamics of antibody Enrollment epidemiologically healthy individual Humoral immunity IgM and IgG IgM antibody IgM responses immunization strategies implication individual Infection infections knowledge Microarray microarray analysis mild patient N protein Neutralization assay neutralizing antibody nucleic acid pandemic peaked produced profile Protein proteome Pseudotyped virus public health raise recruited SARS-CoV-2 SARS-CoV-2 proteome screened sensitivity serological serological survey Serological testing serum significantly symptoms onset the NAT [DOI] 10.1111/all.14622 PMC 바로가기 [Article Type] Article
Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19호중구 세포외 트랩의 순환 마커는 COVID-19 환자에서 예후 가치가 있습니다Article Published on 2021-02-012022-09-11 Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] MERS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome association Asymptomatic Blood cells C-reactive protein cell-free DNA characterized circulating Clinical outcome Coagulation convalescent plasma coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease COVID-19 disease severity Cytokines declined Disease progression disease severity elevated endothelial damage enrolled evaluate Evidence Extracellular extracellular traps fibrinolysis healthy controls healthy individual healthy individuals histone Hospital admission hyperinflammation immunothrombosis in healthy individual in vivo Infection Inflammation Inflammatory cytokines marker moderate moderate to severe Mortality NET NETs neutrophil Neutrophil elastase Neutrophil extracellular trap Neutrophils pathogenic mechanism pathogenic mechanisms patients with COVID-19 plasma plasma sample plasma samples Post-infection progression respiratory respiratory distress Respiratory distress syndrome Respiratory Support SARS-CoV2 severe disease syndrome target targets therapeutic intervention thrombosis thrombotic thrombotic microangiopathy TRAP value were assessed White blood cells with COVID-19 [DOI] 10.1161/ATVBAHA.120.315267 PMC 바로가기 [Article Type] Article
Stereotypic neutralizing V H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individualsCOVID-19 환자 및 건강한 개인에서 SARS-CoV-2 스파이크 단백질 수용체 결합 도메인에 대한 고정형 중화 V H 항체Research Article Published on 2021-01-272022-09-10 Journal: Science Translational Medicine [Category] 변종, 진단, [키워드] antibody binding binding domain composed de novo develop Evidence evidence of exposure to Genes healthy individual healthy individuals heavy chain host cells Human IgA2 IgG1 IgG2 IgG3 IGHJ6 IGHV IGHV3-53 IGHV3-66 IgM IgM isotype IgM isotypes Immunoglobulin in healthy individual in vitro infected with SARS-CoV-2 inhibit inhibiting light chains memory B cell memory B cells NAb NAbs naïve B cell naïve B cells neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody no evidence of occurred Patient patients with COVID-19 produced protective immunity RBD Receptor binding domain Replication resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain somatic mutations Spike protein subtype suggested switching the RBD Viral viral infection viral infections viral replication viruses [DOI] 10.1126/scitranslmed.abd6990 PMC 바로가기 [Article Type] Research Article
Identification of risk factors for in-hospital death of COVID – 19 pneumonia — lessions from the early outbreakCOVID-19 폐렴의 병원 내 사망 위험 요소 식별 - 초기 발병의 교훈Research Article Published on 2021-01-252022-09-01 Journal: BMC Infectious Diseases [Category] 진단, 치료제, [키워드] 2019 novel coronavirus 95% CI acute respiratory distress acute respiratory distress syndrome addition Admission advanced age affecting age albumin albumin levels analyzed Anti-viral treatment Antibiotics ARDS cardiovascular disease Characteristics Clinical characteristics Clinical presentations collected confidence interval Corticosteroids cough COVID COVID-19 COVID-19 infection COVID-19 patients COVID-19 pneumonia creatine creatine kinase creatinine D-dimer diabetes diagnosed with COVID-19 died disease Dyspnea elevated enrolled epidemiological Factor fatigue Fever followed by healthy individual Hospitalization hypertension identification identify Immunoglobulin In-hospital death in-hospital mortality in-hospital mortality rate independent independent risk factor independent risk factors indicated Intravenous immunoglobulin invasive ventilation Laboratory Laboratory test Lactate lactate dehydrogenase lymphocyte Lymphocytes median age MOST Multivariable regression Noninvasive ventilation Novel coronavirus Odds ratio outbreak outcome parameters Patient plasma Platelet Platelet count Pneumonia Prognosis respiratory respiratory distress Respiratory failure Result Retrospective study risk factor Risk factors Sepsis Septic shock suggested survival Survivors Symptom syndrome therapy underlying disease underlying diseases Wuhan [DOI] 10.1186/s12879-021-05814-4 PMC 바로가기 [Article Type] Research Article
Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19SARS-CoV-2 수용체 ACE2 활성 수준은 대동맥 협착증이 있는 고령 환자에서 매우 높아집니다. COVID-19의 중증도에 대한 바이오마커로서의 ACE2의 의미Original Article Published on 2021-01-202022-09-11 Journal: GeroScience [Category] MERS, 바이오마커, [키워드] ACE2 ACE2 activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Aortic stenosis Biomarker blood pressure cardiovascular complication cardiovascular complications cardiovascular disease cardiovascular diseases cellular receptor chronic inflammation circulating Clinical data coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlated COVID-19 COVID-19 mortality COVID-19 susceptibility CRP drug Ejection fraction elderly Elderly patient elderly patients elevated flow velocity functions GFR healthy individual healthy individuals high mortality higher risk hypertension hypertensive implication independent independent of inflammatory state inhibitor inhibitory Kidney function left ventricular ejection fraction Level no effect Older Patient patients RAAS receptor ACE2 respiratory SARS-CoV-2 SARS-CoV-2 susceptibility serum severe acute respiratory syndrome Coronavirus severity of COVID-19 Support systolic pressure TAPSE the SARS-CoV-2 ventricular ventricular ejection were measured [DOI] 10.1007/s11357-020-00300-2 PMC 바로가기 [Article Type] Original Article
Is COVID-19 a high risk factor for lung cancer? A protocol for systematic review and meta-analysisCOVID-19는 폐암의 고위험 인자입니까? 체계적인 검토 및 메타 분석을 위한 프로토콜5700 Published on 2021-01-082022-08-31 Journal: Medicine [Category] COVID-19, meta-analysis, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approval asymptomatic patient bias risk caused Clinical outcome Clinical treatment Complication coronavirus COVID-19 database death develop eligible Ethics evaluate evaluated Evidence Guidance Health healthy individual healthy individuals heterogeneity high risk identify incidence infected with COVID-19 infected with SARS-CoV-2 International lung lung cancer lung cancer patient lung cancer patients Meta-analysis Patient peer-reviewed performed postoperative present Prevalence Prognosis protocol receive reported required research finding respiratory Risk assessment risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe pneumonia Severity rate Stata statistically Support surgical surgical treatment systematic review Treatment worse prognosis [DOI] 10.1097/MD.0000000000023877 PMC 바로가기 [Article Type] 5700
Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China우한시 및 중국 기타 지역에서 SARS-CoV-2의 혈청형 및 무증상 보균자 현황Research Article Published on 2021-01-072022-08-13 Journal: PLoS Neglected Tropical Diseases [Category] Biochemistry, 진단, 치료기술, [키워드] age analyzed antibody approach Asymptomatic Asymptomatic carrier Asymptomatic carriers carrier carriers China city colloidal gold correlated correlation COVID-19 Elimination except for female healthy individual healthy individuals IgG and IgM IgM IgM antibody in healthy individual incidence individual investigated logistic regression model male males nation Older Older age outbreak positive rate Probability Region SARS-CoV-2 SARS-CoV-2 IgG seropositive Seroprevalence Sex significantly significantly higher the SARS-CoV-2 were infected Wuhan [DOI] 10.1371/journal.pntd.0008975 PMC 바로가기 [Article Type] Research Article