High-dose immunoglobulins from convalescent donors for patients hospitalised with COVID-19COVID-19로 입원한 환자를 위한 회복기 기증자의 고용량 면역글로불린Article Published on 2022-02-052022-09-12 Journal: Lancet (London, England) [Category] Fulltext, MERS, 진단, [키워드] convalescent Donor hospitalised Immunoglobulin Patient with COVID-19 [DOI] 10.1016/S0140-6736(22)00112-X PMC 바로가기 [Article Type] Article
Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial입원한 COVID-19 환자를 위한 과면역 면역글로불린(ITAC): 이중 맹검, 위약 대조, 3상, 무작위 시험Clinical Trial Published on 2022-02-052022-09-11 Journal: Lancet (London, England) [Category] Fulltext, MERS, 임상, 진단, 치료제, [키워드] 1:1 95% CI addition adjusted Administered adverse events Analysis Anti-spike antibody assigned baseline carried clinical care clinical trials Complication COVID-19 death donors double-blind duration of symptoms Efficacy Efficacy and safety eligibility criteria end-organ Endpoint enrolled Evidence evidence of Factors finding greater Group allocation heterogeneity hospitalised hospitalised patient Hospitalised patients hyperimmune Immunoglobulin Immunotherapy Infection infusion Interaction International Intravenous immunoglobulin investigators mass mITT mITT analysis modified intention-to-treat Neutralising Antibodies neutralising antibody Organ failure outbreak outcome participant Passive Patient Phase 3 Placebo placebo group placebo-controlled placebo-controlled trial positive Primary outcome randomisation randomised randomised clinical trial Randomised trial Randomly ranged reaction receive Registered Remdesivir Research risk Saline SARS-CoV-2 serious infections significantly Standard of care stratified subgroup subgroups Symptom symptomatic therapy to define Treatment treatment of COVID-19 Trial trial participant trial participants Volume was measured were used with COVID-19 [DOI] 10.1016/S0140-6736(22)00101-5 PMC 바로가기 [Article Type] Clinical Trial
Predictors of mortality among hospitalized COVID-19 patients and risk score formulation for prioritizing tertiary care—An experience from South IndiaResearch Article Published on 2022-02-032022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] adjusted odds ratio Admission age analysed AUC bootstrap Care chain clinical manifestations coefficient collected Comorbidities COVID-19 COVID-19 patient datasets diabetic patient distribution elevated Factor Gender health system highest hospitalised Hospitalized hospitalized COVID-19 patient hypertension lab male management Mortality mortality rate multivariable logistic regression NLR offered Patient care predicted predictor Rate reaction risk risk score RT-PCR south India Univariate analysis urea utilised vital signs [DOI] 10.1371/journal.pone.0263471 PMC 바로가기 [Article Type] Research Article
Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trialCOVID-19(DisCoVeRy)로 입원한 환자의 치료를 위한 렘데시비르 + 표준 치료 대 표준 치료 단독: 3상, 무작위, 대조, 공개 시험Clinical Trial Published on 2022-02-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] Fulltext, MERS, 임상, 치료법, 치료제, [키워드] Abstract activities activity acute respiratory distress acute respiratory distress syndrome adaptive Administered Adult patient Adult patients Analysis antiviral efficacy assigned Bacterial infection Belgium block Breastfeeding Chronic kidney disease clinical clinical benefit Clinical efficacy clinical evidence Clinical research clinical status Combination Commission computer-generated conducted control group Controlled trial COVID-19 criteria death development discharged distribution elevated elevated liver enzymes eligible enrolled Europe European evaluate evidence of exclusion criteria extracorporeal membrane oxygenation followed by France French group Health care hepatorenal syndrome high flow oxygen devices hospital hospitalised Hydroxychloroquine Inclusion indication Innovation intention-to-treat population interferon interferon beta Interferon beta-1a intravenous intravenous infusion Invasive mechanical ventilation investigators Kidney disease laboratory-confirmed SARS-CoV-2 infection limitation liver enzymes Lopinavir Lopinavir-ritonavir Luxembourg material Ministry of Health modified intention-to-treat multicentre no significant difference non-invasive ventilation not significant Occurrence Odds ratio once daily one health Open-label Ordinal Scale oxygen oxygen supplementation oxygen support participant Patient Phase 3 Pneumonia Portugal Pregnancy Primary outcome random assignment randomisation randomised Randomly receive Regional Registered Remdesivir required requiring supplemental oxygen respiratory distress ribavirin Ritonavir Safety SARS-CoV-2 SARS-COV-2 infection Secondary outcomes Serious Adverse Event Serious Adverse Events seven-point ordinal scale Severity of disease Sponsor Standard of care stratified supplemental oxygen Support symptomatic syndrome the WHO translation Treatment treatment group treatment groups Trial Tumor union ventilator were excluded WHO ordinal scale with COVID-19 [DOI] 10.1016/S1473-3099(21)00485-0 PMC 바로가기 [Article Type] Clinical Trial
Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort studyResearch Article Published on 2022-02-012022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome analysed Clinical diagnosis Clinical features clinically coronavirus disease Coronavirus-2 COVID-19 defined determine Diagnosis diagnostics discharge gold standard Haematology hospitalised hospitalised patient increase majority multiplex negative and positive negative RT-PCR NHS Patient positive positive result proportion respiratory sample retrospective cohort study reverse transcription PCR RNase P RT-PCR RT-PCR test RT-PCR testing RT-PCR tests SARS-CoV-2 SARS-CoV-2 RT-PCR sensitivity Sensitivity and specificity sequence tested United Kingdom upper respiratory tract [DOI] 10.12688/wellcomeopenres.16342.2 PMC 바로가기 [Article Type] Research Article
Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and PharmacodynamicsCOVID 폐렴에서 정맥내 나파모스타트 메실레이트의 무작위 대조 시험: 안전성, 약동학 및 약력학을 조사하기 위한 1b/2a상 실험 연구Clinical Trial Published on 2022-02-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] 95% CI Administered adverse events Analysis Anti-inflammatory Anticoagulant anticoagulant effect anticoagulant effects antiviral activity assigned average characterisation Controlled trial COVID COVID-19 COVID19 creatinine credible interval demonstrated dose Edinburgh Endpoint endpoints Evidence evidence of Hospital stay hospitalised hospitalised patient Hospitalised patients inactive independent Infectious diseases intravenous intravenous infusion manuscript maximum mean difference mesylate metabolites nafamostat Nafamostat mesylate observé Odds ratio open open label Oxford oxygen Patient patients Pharmacodynamics pharmacokinetics phase Phase 2 PK data plasma platform Pneumonitis Primary outcome Primary outcomes progressed randomised randomised controlled trial Randomly rate ratio receive reported Repurposed drug Research respiratory Respiratory medicine response SARS-CoV-2/COVID-19 Seven significantly higher significantly more SOC Standard of care statistically significant difference therapy Tolerability Total Total manuscript word count. Trial university with COVID-19 [DOI] 10.1016/j.ebiom.2022.103856 PMC 바로가기 [Article Type] Clinical Trial
Spatial analysis of COVID-19 hospitalised cases in an entire city: The risk of studying only lattice data도시 전체의 코로나19 입원환자 공간분석: 격자 데이터만 연구하는 위험성Article Published on 2022-02-012022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis automatically Cases and controls caused city conditioned consequence Control COVID-19 COVID-19 disease Decision making described detect disease Economic inequality effective Epidemiological study facilitate Gini Index global pandemic greater highest hospitalisation hospitalisations hospitalised incidence index interior Lattice Lattice data limit Local measure Measures pandemic problem problems random Random sample real time risk risk ratio SARS-CoV-2 significantly significantly higher Social distancing measure Spain Spatial point patterns. suggested [DOI] 10.1016/j.scitotenv.2021.150521 PMC 바로가기 [Article Type] Article
Systemic administration of glucocorticoids, cardiovascular complications and mortality in patients hospitalised with COVID-19, SARS, MERS or influenza: A systematic review and meta-analysis of randomised trialsCOVID-19, SARS, MER 또는 인플루엔자로 입원 한 환자의 글루코 코르티코이드, 심혈관 합병증 및 사망률의 전신 투여 : 무작위 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-02-012022-09-10 Journal: Pharmacological research [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] 95% CI administration all-cause mortality benefit cardiometabolic cardiovascular complication cardiovascular complications Confidence intervals COVID-19 Dexamethasone Effects estimate Follow-up glucocorticoid Glucocorticoids hospitalised in-hospital mortality Influenza lower mortality Mantel-Haenszel mechanical ventilation MERS Meta-analysis Mortality objective outcomes oxygen Patient patients Placebo random effect randomisation Randomised trial randomised trials receiving reduce reduce mortality reduced reduction renal function reported respiratory Respiratory Support respiratory viral infections Result risk severe COVID-19 significantly standard care Steroids subgroup subgroups systematic review systemic systemic glucocorticoid systemic glucocorticoids Treatment trials Viral was reduced were used with COVID-19 worsening [DOI] 10.1016/j.phrs.2021.106053 PMC 바로가기 [Article Type] Meta-Analysis
Antibiotic Therapy in the Treatment of COVID-19 Pneumonia: Who and When?Article Published on 2022-01-312022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] 95% CI 95% confidence interval Accuracy adjusted odds ratio Admission age antibiotic Antibiotic therapy antibiotic use Antibiotics AUC Bacterial bacterial co-infection Bacterial infection Bacterial infections C-reactive protein Clinical outcome co-morbidity conducted COVID-19 COVID-19 pneumonia patient defined Deterioration diagnose Diagnosis diagnostic diarrhoea Effect empiric antibiotic evaluate evaluated had more hospitalised in-hospital mortality Infectious disease Inflammatory marker intensive care less moderate Mortality Observational cohort study Patient patients patients with COVID-19 Pneumonia presenting Prevent procalcitonin level receiving Sensitivity and specificity severe COVID-19 severity of COVID-19 similarity Singapore subsequent treated Treatment treatment for COVID-19 white cell with COVID-19 [DOI] 10.3390/antibiotics11020184 PMC 바로가기 [Article Type] Article
Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study남아프리카 공화국에서 SARS-CoV-2 오미크론 변이체의 임상 중증도에 대한 조기 평가: 데이터 연계 연구Articles Published on 2022-01-292022-09-10 Journal: Lancet (London, England) [Category] 변종, [키워드] 95% CI adjusted odds ratio Admission African Analysis center Clinical severity Control COVID-19 COVID-19 case COVID-19 cases COVID-19 PCR test delta variant Department diagnosed diagnosed with COVID-19 disease control disease severity Factor finding foundation funding Genome sequencing Hospital admission hospitalisation hospitalisations hospitalised Immunity increase in individual infected individuals Infection infections Laboratory Laboratory test Medical Research Council Medicine Melinda Gate Melinda Gates multivariable logistic regression multivariable logistic regression models National Odds ratio Omicron variant PCR test PCR tests prevention proportion reduced reported S gene S gene target failure SARS-CoV-2 SARS-CoV-2 genome severe disease severity significantly significantly lower Society South South Africa TaqPath the SARS-CoV-2 Thermo Fisher Scientific variant Wellcome Trust [DOI] 10.1016/S0140-6736(22)00017-4 PMC 바로가기 [Article Type] Articles