Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice엔도솜 산성화 억제제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스에서 바이러스성 폐렴을 완화합니다Research Published on 2021-02-272022-09-10 Journal: Virology Journal [Category] MERS, 치료기술, 치료제, [키워드] 293T 293T-ACE2 cells acidic pH alveolar Analysis Antiviral effect antiviral effects bafilomycin Bafilomycin A1 caused CCK-8 CCK-8 assay Cell Chloroquine Clinical use coronavirus disease Coronavirus disease 2019 COVID-19 detect distribution Drug development Endosomal acidification endosome Endosomes eosin evaluate global pandemic hACE2 hematoxylin Huh-7 In situ hybridization Infection infiltration Inflammatory inhibitor inhibitors investigated lung tissue lung tissues pathological change peribronchiolar perivascular tissues Pneumonia proliferation provide reduced Replication Research Result RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly staining Structure suppress the SARS-CoV-2 transgenic mice used to evaluate Vero E6 Vero E6 cell VERO E6 cells viability Viral Viral pneumonia viral replication was used [DOI] 10.1186/s12985-021-01515-1 PMC 바로가기 [Article Type] Research
Case Report: Dengue and COVID-19 Coinfection in Thailand사례 보고: 태국의 뎅기열 및 COVID-19 동시 감염Case Reports Published on 2021-02-152022-09-10 Journal: The American Journal of Tropical Medicine and Hygi [Category] MERS, SARS, 치료기술, [키워드] Alanine Alanine transaminase aspartate Aspartate transaminase Blood Chest radiograph clinical manifestations Co-infection Coinfection COVID-19 Dengue Dengue fever dengue virus Denmark diagnosed Diagnosis Disease progression Diseases elevated Fever Health policy Healthcare system Infection infiltration integration Laboratory laboratory result Laboratory results leukopenia myalgia Nasopharyngeal swab nonspecific physician point-of-care profiles public health required reverse transcriptase RT-PCR SARS-CoV-2 serotype Supportive treatment Symptom Travel tropical vomiting [DOI] 10.4269/ajtmh.20-1340 PMC 바로가기 [Article Type] Case Reports
Obesity, Nutrients and the Immune System in the Era of COVID-19Review Published on 2021-02-132022-10-31 Journal: Nutrients [Category] COVID-19, MERS, [키워드] acute respiratory distress addition adipocyte adipocytes adipose Affect alteration Apoptosis cardiovascular complications caused characteristic chronic disease circulation complications Compound COVID-19 cytokine Cytokines death decrease disrupting Disseminated intravascular coagulation Effects element endothelial Endothelial dysfunction Endotheliitis excess Excessive activation fat Fat mass forms function hypercoagulability hypertrophic Immune cell immune cells immune system increase increase in induce Infection infection-related mortality Infectious complications infiltration Inflammasome Inflammation inflammatory state insulin resistance Leptin Lipid Lymphoid Organ Macrophage multiple organ failure NLRP3 inflammasome nutrient obese obesity pro-inflammatory promote recruitment released responsible risk risk factor risk of infection SARS-COV-2 infection saturated secondary bacterial infection severe complication severe COVID-19 Severe infection Shock shown subjects sugar susceptibility syndrome System systemic inflammatory These cells tissue [DOI] 10.3390/nu13020610 PMC 바로가기 [Article Type] Review
A double blinded placebo controlled comparative clinical trial to evaluate the effectiveness of Siddha medicines, Kaba Sura Kudineer (KSK) & Nilavembu Kudineer (NVK) along with standard Allopathy treatment in the management of symptomatic COVID 19 patients – a structured summary of a study protocol for a randomized controlled trial증상이 있는 COVID 19 환자의 관리에서 표준 동종 요법 치료와 함께 Siddha 의약품, Kaba Sura Kudineer(KSK) 및 Nilavembu Kudineer(NVK)의 효과를 평가하기 위한 이중 맹검 위약 대조 비교 임상 시험 - 에 대한 연구 프로토콜의 구조화된 요약 무작위 대조 시험Letter Published on 2021-02-112022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] acute respiratory distress syndrome addition Adverse adverse events age age and sex appearance Arm Asymptomatic Bacterial biochemical markers blinded block calculated CAM change Chemical clinical clinical symptom Clinical symptoms clinical trial Complication complications Controlled count COVID COVID 19 COVID 19 patient CRP Ct value CTRI D-dimer Data analysis Date determine diagnose dimer dissemination drug Effect Effectiveness element eligibility eliminated enrolment evaluate exploratory ferritin food GMP group Herbal Hospital stay IL 6 IL6 incidence India Infection infiltration Inflammatory marker inflammatory markers Informed consent investigators involved Laboratory LDH literature management marker Medical Sciences Medicine Medicines Microsoft Excel moderate symptom moderate symptoms morning Night number objective outcome participant Patient patients PCR Placebo Pneumonia profile protocol randomised controlled trial randomization Randomized Randomized controlled trial Ratio recruited recruitment reduce reduction Registered Registration registry reported respiratory respiratory distress Respiratory distress syndrome risk Sample Sample size SARS-CoV-2 secondary Secondary objectives Secondary outcomes severe COVID-19 symptoms Siddha Siddha Medicine smoking SPIRIT guidelines statistician status Study protocol submission Sura symptomatic Taste tea the disease time Total Treatment Trial trial protocol Trial registration value Viral Viral load Viral pneumonia website were blinded [DOI] 10.1186/s13063-021-05041-x PMC 바로가기 [Article Type] Letter
An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19?Immunology Published on 2021-02-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] ACE2 acute respiratory syndrome antiviral response B cell CD68 changes in co-expressed coronavirus coronavirus disease COVID-19 COVID‐19 Cytokines determine disease Effect Evidence Features flow cytometry hypoxic immune Immune cell immune cells Immune status Infection infiltration Inflammatory Luminex assay Macrophage MCP-1 memory B cells Mild mother NK cells no significant difference pandemic Patient patients percentage Peripheral blood Placenta Pregnancy pregnant women receptors recovering from COVID-19 recovery SARS-CoV-2 subset TMPRSS2 umbilical cord blood unique women [DOI] 10.3389/fimmu.2021.631044 PMC 바로가기 [Article Type] Immunology
A case of successful treatment of severe COVID-19 pneumonia with favipiravir and tocilizumab in post-kidney transplant recipient신장이식 후 환자에서 파비피라비르와 토실리주맙으로 중증 코로나19 폐렴을 성공적으로 치료한 1예Case Reports Published on 2021-02-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] SARS, 진단, 치료제, [키워드] acute diarrhea Acute kidney injury Administered Admission AKI Anti-viral treatment Azithromycin blood count caused Chain Reaction complete blood count COVID-19 COVID-19 infection darunavir diarrhea drug drug interaction Favipiravir Fever followed by high-flow nasal cannula oxygen therapy hospital Hospitalization Hydroxychloroquine IL-6 Immunosuppression infiltration initiated Interaction kidney transplant kidney transplant recipient lymphopenia MMF mycophenolate mycophenolate mofetil nasal nasal cannula nasal swab onset of fever oxygen Oxygen therapy Oxygen treatment patchy Patient PCR Pneumonia polymerase chain polymerase chain reaction Prednisolone required rising Ritonavir serum Serum IL-6 serum IL-6 level Severe COVID-19 pneumonia Stool Supportive treatment tacrolimus Tocilizumab transferred Treatment X-ray [DOI] 10.1111/tid.13388 PMC 바로가기 [Article Type] Case Reports
Various radiological findings in patients with COVID-19: A case seriesCase Series Published on 2021-01-222022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] abnormality Abnormality findings affected age Care case sery change Characteristics composed consolidation COVID-19 COVID-19 patient CXR definitive diagnosis effective female Follow-up GGO Ground glass opacity Health hospital infiltration initial screening interstitial lung Lungs males Mild moderate Patient patients patients with COVID-19 Plain chest X-ray Pneumonia polymerase chain presentation radiological radiological finding required respiratory disorders reverse transcription RT-PCR subpleural Thoracic Thoracic CT scan Viral pneumonia [DOI] 10.1016/j.amsu.2021.01.030 PMC 바로가기 [Article Type] Case Series
Construction of a risk map to understand the vulnerability of various types of cancer patients to COVID‐19 infectionOriginal Article Published on 2021-01-212022-10-30 Journal: MedComm [Category] COVID-19, [키워드] abundantly expressed ACE2 ACE2 expression analyzed attacks Breast cancer Cancer cancer patient Cancer patients cancer type cells cohorts construction COVID‐19 COVID‐19 infection COVID‐19 dataset datasets demonstrated Evidence global pandemic high risk higher risk human cell immune infiltration indicate Infection infection risk infiltration invasive involved lymphocyte mechanism mRNA expression Novel coronavirus organ ovarian ovarian cancer Pathogenesis patient cohorts patients poor prognosis potential risk Prognosis reported risk RNA sequencing tumor‐infiltrating lymphocytes Variation [DOI] 10.1002/mco2.53 PMC 바로가기 [Article Type] Original Article
Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical ReviewReview Published on 2021-01-032022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activated Activation acute distress respiratory syndrome acute respiratory distress addition ARDS bleeding cause clinical evidence clinical manifestation clinical presentation clinician Coagulation coagulation cascade coagulation disorder coagulation factor coagulation tests Coagulopathy coronavirus disease COVID-19 COVID-19 patients Critically ill patient Disseminated intravascular coagulation endothelial endotoxin hemorrhagic event heparin Ill impairment incidence infiltration Inflammatory inhibitors Laboratory Laboratory test marker mechanism microthrombi Necrosis pathophysiology pathway Platelet platelet activation Platelets Protein protein S quantification question Regulatory reported respiratory responsible review risk supportive care syndrome thromboembolic Thromboembolic events thrombosis tissue variety [DOI] 10.3390/jcm10010140 PMC 바로가기 [Article Type] Review
Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection. The DEDALO projectCOVID-19 감염에서 NO-cGMP-PDE5 경로를 표적으로 합니다. 데달로 프로젝트Article Published on 2021-01-012022-09-11 Journal: Andrology [Category] SARS, 임상, 치료제, [키워드] acting activated T cells administration alveolar ANG-II anti-inflammatory response biological drug biological drugs cause Cell cGMP clinical trial clotting Complication complications of COVID-19 contraindication contraindications COVID-19 COVID-19 disease COVID-19 infection cyclic GMP cytokine cytokine release Cytokine storm Cytokines diabete diabetes Diabetes Mellitus Diabetic diffusion disease downregulation drug dysregulation endothelial Endothelial cell endothelial cell damage Evidence expressed favor fibrosis IL-6 immune system implication IMPROVE infiltration inhibiting interstitial interstitial pneumonia limit Liver function low-grade inflammation Lungs material men mesenchymal cells Metabolic diseases modulating monocyte Necrosis nitric oxide Numerous offer ongoing trial ongoing trials outbreak oxygen pandemic pathophysiology pathway Patient patients with COVID-19 PDE5 inhibitor PDE5 inhibitors performed positive presenting pro-inflammatory cytokines pulmonary artery pulmonary fibrosis raise reducing renal impairment resource respiratory respiratory infection responsible severe COVID-19 disease Sildenafil smooth muscle smooth muscle cell smooth muscle cells stability storm switching systematic review systemic disease T cells targeting temperature thrombotic Thrombotic complications transition type 2 diabete Type 2 diabetes mellitus Vascular vessel widespread [DOI] 10.1111/andr.12837 PMC 바로가기 [Article Type] Article