Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesisResearch Published on 2021-07-162022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] accelerated ADME ADMET alkaloid anti-SARS-CoV-2 binding affinity binding energy clinical trials complex Compound compounds COVID-19 COVID-19 vaccine distribution drug-likeness effective exhibited highlight HIV reverse transcriptase in silico in viral inhibitors of SARS-CoV-2 inhibitory investigated involved Ligand mechanism metabolism molecular molecular docking non-structural protein non-structural proteins non-toxic NSP Nsp3 Nsps Pathogenesis Pathways Polyphenolics predicted property Result SARS-CoV-2 SARS-CoV-2 pathogenesis Seven Structure supplementary material terpenoids Toxicity transcriptase Treatment vital role [DOI] 10.1186/s43141-021-00206-2 PMC 바로가기 [Article Type] Research
Tai chi improves psychoemotional state, cognition, and motor learning in older adults during the COVID-19 pandemicRandomized Controlled Trial Published on 2021-07-152022-10-05 Journal: Experimental gerontology [Category] SARS, 임상, [키워드] addition Adults autonomic BDNF change Cognitive function condition control group correlated COVID-19 pandemic Depression depressive symptom determine effective intervention heart rate heart rate variability IMPROVE improvement inhibitory Intervention investigated Mental motor Motor Function nervous system Older pandemic participant Perceived stress physical Randomized Stress switching Tai Chi were assessed [DOI] 10.1016/j.exger.2021.111363 PMC 바로가기 [Article Type] Randomized Controlled Trial
Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drugShort Communications Published on 2021-07-132022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] ACE ACE 2 receptor andrographolide angiotensin-converting enzyme 2 Antiviral bind binding candidate Cell Coronaviridae family database docking result domain drugs exhibit Genome homology host cell host cells identify in silico in silico Approach infect Infection inhibitor inhibitory Interaction Nsp12 plant protein sequence Proteins RBD RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 searched spike glycoprotein Spread tested the SARS-CoV-2 virus unique virus [DOI] 10.1186/s43141-021-00201-7 PMC 바로가기 [Article Type] Short Communications
Copper-Silver Nanohybrids: SARS-CoV-2 Inhibitory SurfacesArticle Published on 2021-07-132022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] acute respiratory syndrome antiviral property characterized copper coronavirus COVID-19 infection Efficacy example Health hospital Human human-animal interfaces inhibited inhibitory inhibitory surfaces lesson Microscope Microscopy nanohybrids pandemic parameter reveal SARS-CoV-2 SEM silver surface TEM the SARS-CoV-2 Toxicity Transmission X-ray spectroscopy [DOI] 10.3390/nano11071820 PMC 바로가기 [Article Type] Article
An intranasal vaccine durably protects against SARS-CoV-2 variants in miceArticle Published on 2021-07-102022-11-01 Journal: Cell Reports [Category] COVID-19, SARS, [키워드] Abstract Administered antibody Antibody neutralization Antibody Response attenuate B.1.1.28 B.1.351 B.1.617.1 Bone marrow chimpanzee adenovirus-vectored vaccine Complete COVID-19 cross-protection cross-protective dose dose response dose-dependent manner Durability Efficacy function IgA IgG Immunity immunization immunogenic induce inhibitory intranasal intranasally long-lived plasma cell Lower respiratory tract mice mucosal immunity neutralized Neutralizing Pathogenesis PROTECT protection Protective provide reported robust SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant secreting serum serum antibody Spike protein trials vaccination Vaccine vaccine dose variant variants of concern viruses [DOI] 10.1016/j.celrep.2021.109452 PMC 바로가기 [Article Type] Article
Medical students’ perception towards E-learning during COVID 19 pandemic in a high burden developing countryResearch Article Published on 2021-07-102022-10-28 Journal: BMC Medical Education [Category] COVID-19, SARS, [키워드] Africa bandwidth conducted correlation country COVID 19 COVID-19 infection cross-sectional survey disseminate Distance learning e-learning effective strategy evaluated example face-to-face interaction Facebook Factor Faculty of Medicine highlight implementation inhibitory Inhibitory effects Internet lack lockdown majority medical education MOST overcome pandemic positive problem questionnaire Result shifting social media platform Spread Support university WhatsApp [DOI] 10.1186/s12909-021-02811-8 PMC 바로가기 [Article Type] Research Article
Poor humoral and T-cell response to two-dose SARS-CoV-2 messenger RNA vaccine BNT162b2 in cardiothoracic transplant recipients흉부 이식 수혜자의 2회 용량 SARS-CoV-2 메신저 RNA 백신 BNT162b2에 대한 체액 및 T 세포 반응 불량Original Paper Published on 2021-07-092022-09-11 Journal: Clinical Research in Cardiology [Category] MERS, 진단, 치료법, [키워드] Abbott age analysed anti-SARS-CoV-2 average BioNTech/Pfizer (BNT162b2) vaccine blood sample Blood samples BNT162b2 BNT162b2 vaccine booster dose cellular response control group COVID-19 infection detectable domain domains dose ELISA Euroimmun Evidence evidence of excluded exhibited functional Genscript healthy heart humoral IgG immune response immune responses immunoassays Immunocompromised patient Immunocompromised patients immunogenicity Immunoglobulin infectious agent infectious agents inhibitory interferon interferon-γ lung majority membrane protein Messenger RNA Neutralizing antibodies neutralizing antibody nucleocapsid Organ transplant Patient patients peptides Pfizer-BioNTech Poor prime Qiagen QuantiFERON recipient recipients robust SARS-CoV-2 Seroconversion shown significant increase Specific T-cell response Spike protein stimulated T-cell T-cell Response tested titre Transplant recipients vaccination Vaccine Vaccines Viral viral spike was measured Whole blood [DOI] 10.1007/s00392-021-01880-5 PMC 바로가기 [Article Type] Original Paper
The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort studyArticles Published on 2021-07-082022-10-29 Journal: The Lancet Rheumatology [Category] COVID-19, [키워드] 95% CI All participant B.1.1.7 variant BNT162b2 BNT162b2 vaccine Cellular immune response cellular response clinical effectiveness Cohort cohort study consecutive patient Control controls Coverage COVID-19 vaccine COVID-19 vaccine trials defined determine Diagnosis Dilution East eligible England evaluate evaluated extended interval females finding first dose foundation funding groups healthy control healthy controls humoral Humoral immunity IL-17 IL-2 IL-21 IL-23 immune response Immune-mediated inflammatory disease immunogenicity Immunosuppressant Immunosuppression individual inhibitors inhibitory interferon-γ IQR London lowest males median median age methotrexate monotherapy Necrosis neutralising antibody response Neutralising titre NHS of BNT162b2 participant Participants Patient Pfizer-BioNTech preserved Primary outcome receive receiving recruited Seven significantly lower single dose South spike glycoprotein spike-specific T-cell response study population the healthy the SARS-CoV-2 therapeutic Therapies Thoma TNF Trust vaccination vaccine immunogenicity Volunteer were excluded white wild-type SARS-CoV-2 [DOI] 10.1016/S2665-9913(21)00212-5 PMC 바로가기 [Article Type] Articles
A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronavirusesResearch Published on 2021-07-082022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] Antiviral component conducted coronavirus COVID-19 Diseases E. coli effective EK1 ELISA evaluate exhibited expressing GL25E glycan GRFT HCoV-229E HCoV-NL63 HCoV-OC43 HIV HR1 domain human coronavirus in vitro in vivo Infection inhibit inhibited inhibiting inhibitory inhibitory activity intranasally mechanism of action MERS-CoV mice mutants mutated Newborn Ni-NTA peptide performed Prevent previous study Prophylactic protective effect Protein Proteins pseudovirus purified Result S protein S2 subunit SARS-CoV SARS-CoV-2 SARS-COV-2 infection selected shown significantly more Spike protein the S1 subunit therapeutic treat were expressed wild-type [DOI] 10.1186/s13578-021-00638-w PMC 바로가기 [Article Type] Research
Strawberry and Ginger Silver Nanoparticles as Potential Inhibitors for SARS-CoV-2 Assisted by In Silico Modeling and Metabolic ProfilingArticle Published on 2021-07-062022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] AAK1 ADP AgNP AgNPs Analysis anti-SARS-CoV-2 Antiviral antiviral activity AutoDock biosynthesized carried cathepsin caused Compound conducted COVID-19 demonstrated docking study drug candidate evaluated fatty acids FIVE Fragaria ginger globe Health high stability High-resolution highest Human in silico In silico modeling indicate inhibitor inhibitory Interaction life-threatening metabolic metabolomic profiling Microscope modeling molecular molecular docking MPro MTT nanoparticle Nanoparticles Novel coronavirus overcome pandemic phosphatase PLPro Pneumonia Potential predict Profiling Protein Proteins provide responsible SARS-CoV-2 SARS-CoV-2 protein Secondary Metabolite Seven silver spectrophotometric analysis strawberry target TEM the SARS-CoV-2 Transmission Viral protein was performed were used zeta potential Zingiber [DOI] 10.3390/antibiotics10070824 PMC 바로가기 [Article Type] Article