interfere – Page 13 – Communicable Diseases Research

A synthetic defective interfering SARS-CoV-2

Bioengineering

Published on 2021-07-012022-10-28
Journal: PeerJ [Category] COVID-19,

Harnessing immunotherapy to combat COVID-19: A modern snake oil or silver bullet?

COVID-19 퇴치를 위한 면역 요법 활용: 현대의 뱀 기름 또는 은탄?

Review

Published on 2021-07-012022-09-11
Journal: Thérapie [Category] SARS, 진단, 치료제,

[키워드] (hydroxychloroquine) (remdesivir acute respiratory syndrome acute respiratory syndrome coronavirus Anti-viral antibodies Azithromycin caused clinical trial clinical trials Combination convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 serotherapy drug Epidemiology Health human monoclonal antibodies Human monoclonal antibody Hydroxychloroquine IFN-I immune response immune responses immunopathology Immunotherapy Infectious disease interfere interferon Interferon type I interferons intracellular pathogens mAbs modify monoclonal antibodies outcome Pathogenesis Pathogens Patient physician regimen Remdesivir respiratory SARS-CoV-2 serotherapy severe acute respiratory syndrome Coronavirus survival Treatment outcome
[DOI] 10.1016/j.therap.2020.10.004 PMC 바로가기 [Article Type] Review

Interaction of selected terpenoids with two SARS-CoV-2 key therapeutic targets: An in silico study through molecular docking and dynamics simulations

두 개의 SARS-CoV-2 주요 치료 표적과 선택된 테르페노이드의 상호 작용: 분자 도킹 및 역학 시뮬레이션을 통한 in silico 연구

Article

Published on 2021-07-012022-09-11
Journal: Computers in biology and medicine [Category] SARS, 신약개발,

[키워드] 3CL hydrolase ACE2 receptor Amino acid amino acid residue amino acid residues Analysis Antiviral approved drug binding catalytic dyad caused Complete Compound Computational approaches confirmation Contact contact with contrary Course COVID-19 disease docking docking score Drug repurposing effective enzyme growth hydrolase in silico in vitro in vivo inhibit inhibitors inhibitors of SARS-CoV-2 inhibitory Interaction interfere lack Limonoids molecular molecular docking molecular dynamics Molecular dynamics simulation MPro outbreak pharmacokinetic predicted profiles protease Protein provided RBD SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 replication selected spike Spike protein terpenoids the spike protein therapeutic therapeutic target
[DOI] 10.1016/j.compbiomed.2021.104538 PMC 바로가기 [Article Type] Article

Assessing COVID-19-related anxiety and functional impairment amongst nurses in Malawi

Original Research

Published on 2021-06-302022-10-28
Journal: African Journal of Primary Health Care & Family Me [Category] COVID-19, MERS, SARS,

Effect of Tenofovir Disoproxil Fumarate and Emtricitabine on nasopharyngeal SARS-CoV-2 viral load burden amongst outpatients with COVID-19: A pilot, randomized, open-label phase 2 trial

Research Paper

Published on 2021-06-272022-10-04
Journal: EClinicalMedicine [Category] 신약개발, 임상,

[키워드] 1:1 95% CI 95% confidence interval accelerate Adverse adverse events assigned baseline clearance Cohort collected conducted COVID-19 COVID-related symptoms cycle threshold develop died drug discontinuation early treatment Effect emtricitabine Endpoint enrolled enrolment event finding France fumarate funding gastrointestinal side effect hospital hospitalisation in both groups Inclusion increase in Infection interfere IQR less median nasopharyngeal Nasopharyngeal swab Open-label Other Outpatient Patient per day phase 2 trial pilot study Randomized Randomly RdRP receive Registered reported RNA polymerase RT-PCR SARS CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SARS-CoV-2 viral load secondary endpoint severe COVID-19 Standard of care Support symptom onset tenofovir therapy Time to recovery treated treatment group Trial viral burden
[DOI] 10.1016/j.eclinm.2021.100993 PMC 바로가기 [Article Type] Research Paper

Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2

Research Article

Published on 2021-06-242022-10-29
Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS,

[키워드] 293T cells Affect antibodies binding Cell clinical settings cloned co-transfection complement compounds convalescent sera correlated correlation COVID-19 demonstrated dimensions Efficacy Efficiency effort equipment Factor FDA global public health hACE2 high throughput screen identify immune protection in vitro Infection inhibitors of SARS-CoV-2 Interaction interfere Laboratory Live virus monoclonal antibodies Neutralization assay Other Plasmid Pseudotyped virus Rapid reagent Research Result sera stable cell line stable cell lines the SARS-CoV-2 the vaccine therapeutic time-consuming vaccination Vaccine virus titer was tested
[DOI] 10.1371/journal.ppat.1009683 PMC 바로가기 [Article Type] Research Article

Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels?

중증 COVID-19에 대한 덱사메타손: 세포 및 분자 수준에서 어떻게 작용합니까?

Review

Published on 2021-06-232022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 치료제,

[키워드] accompanied activity anti-inflammatory property Bacterial sepsis cause caused characteristic coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 develop Dexamethasone Diseases effective encoding proteins facilitate glucocorticoid glucocorticoid dexamethasone glucocorticoid receptor (GR) Glucocorticoids host cell Hypothesis hypothetical impacted infected cells Infection Infectious diseases Inflammation Influenza influenza pneumonia Innate immunity interfere life-threatening Local mechanism modulated modulating non-infected not affect pathologic Pneumonia potential molecular Protein Replication reported respiratory Respiratory failure respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection Sepsis Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) severe COVID-19 severe respiratory syndrome significantly steroid systemic inflammation Treatment type I interferons (IFNs) unique Viral Viral diseases viral replication virus viruses work
[DOI] 10.3390/ijms22136764 PMC 바로가기 [Article Type] Review

A Novel SARS-CoV-2 Viral Sequence Bioinformatic Pipeline Has Found Genetic Evidence That the Viral 3′ Untranslated Region (UTR) Is Evolving and Generating Increased Viral Diversity

Microbiology

Published on 2021-06-212022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] 3cpsdummy′UTR accumulating Analysis analyzed annotation arising assist B.1.1.7 Bioinformatic conserved dataset Diversity downstream format Frequency Genetic testing Genome genomes greater Host immune response inactivation Increased interfere K68 less novel nucleotide diversity (π) orf3a gene ORF8 ORF8 gene performed Polymorphisms processed Region regions researcher SARS-CoV-2 SARS-CoV-2 genome sequencing SARS-CoV-2 lineage SARS-CoV-2 sequencing SARS-CoV-2 variants SARS-CoV-2 viral sequence sequencing errors Spread stop codon Tajima’s D-statistic United Kingdom UTR variant Variation VCF viral evolution virulence
[DOI] 10.3389/fmicb.2021.665041 PMC 바로가기 [Article Type] Microbiology

Sphingolipids as Modulators of SARS-CoV-2 Infection

Cell and Developmental Biology

Published on 2021-06-172022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] ACE2 acid acute respiratory syndrome angiotensin-converting enzyme 2 bind Biomarker blocked Cell cell interaction cell membranes ceramide condition consequence coronavirus Course COVID-19 COVID-19 disease COVID-19 pandemic Culture drug drugs epithelial cell line epithelial cells facilitated functional indicate individual Infection interfere Lipid mechanism modulator molecular basis nasal Prognostic factor protease recent receptor reduced required S1PR1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serum level severity shown sphingolipid sphingosine Spike protein subsequent the disease Treatment viral entry virus virus particle
[DOI] 10.3389/fcell.2021.689854 PMC 바로가기 [Article Type] Cell and Developmental Biology

Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry

Article

Published on 2021-06-142022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS, SARS,

[키워드] ADE antibodies antibody Antibody titer Antibody-dependent enhancement Antigen binding block viral entry contribute COVID-19 Critical cross-reactive antibody cross-reactivity displaying ELISA experiment expressing glycan glycosylation gp120 HIV-1 immune response immunoassays immunoreactivity implication Infection interfere Interpretation Microbiology motif Neutralizing nine pseudovirus reactive receptor engagement SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein selected serological assays Spike protein Spike proteins the SARS-CoV-2 therapeutic unlikely vaccine immunogen Virology virus Virus neutralization
[DOI] 10.1038/s41598-021-91746-7 PMC 바로가기 [Article Type] Article