Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination동종 및 이종 CoronaVac 또는 BNT162b2 백신 접종 후 SARS-CoV-2 Omicron 변이체 BA.1에 대한 중화 항체Article Published on 2022-03-012022-09-11 Journal: Nature Medicine [Category] SARS, 변종, 진단, [키워드] antibody Antibody titer BNT162b2 booster booster dose circulating convalescent CoronaVac country dominant dose Effectiveness elicited geometric mean geometric mean titer GMT Heterologous homologous individual infected individual Infection Live virus Messenger RNA Neutralizing activity of BNT162b2 omicron Omicron variant plaque plaque reduction neutralization PRNT reduced reductions reductions in SARS-CoV-2 SARS-CoV-2 virus serum serum antibody Spread the SARS-CoV-2 threshold to define vaccinated individual vaccinated individuals vaccination Vaccine variant virus wild-type WT virus [DOI] 10.1038/s41591-022-01704-7 PMC 바로가기 [Article Type] Article
COVID-19 Vaccination Effectiveness Against Infection or Death in a National U.S. Health Care System : A Target Trial Emulation Study미국 국립 의료 시스템의 감염 또는 사망에 대한 COVID-19 예방 접종 효과 : 표적 시험 에뮬레이션 연구Article Published on 2022-03-012022-09-11 Journal: Annals of internal medicine [Category] SARS, 변종, [키워드] 1:1 95% CI advanced age Affair Against black both groups Care Characteristics Comorbidity Control controls COVID-19 COVID-19 vaccine COVID-19 vaccines death defined Department determine distribution dose Effectiveness effort example Follow-up group Health Health care Health care system Hispanic in both groups increasing age Infection lack male Messenger RNA Moderna pandemic Pfizer-BioNTech Population Racial receiving reported SARS-COV-2 infection SARS-CoV-2 variants System target Trial vaccination vaccine dose veteran [DOI] 10.7326/M21-3256 PMC 바로가기 [Article Type] Article
Interest of a third dose of BNT162b2 anti-SARS-CoV-2 messenger RNA vaccine after allotransplant동종이식 후 BNT162b2 anti-SARS-CoV-2 메신저 RNA 백신 3차 접종에 대한 관심Article Published on 2022-03-012022-09-12 Journal: British Journal of Haematology [Category] MERS, SARS, 진단, [키워드] Abstract acute respiratory syndrome Allogeneic allogeneic haematopoietic stem cell transplantation anti-SARS-CoV-2 BNT162b2 Cell coronavirus disease Coronavirus disease 2019 (COVID-19) Coronavirus-2 dose interest Messenger RNA of BNT162b2 SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) mRNA third dose Vaccine [DOI] 10.1111/bjh.17911 PMC 바로가기 [Article Type] Article
Immunogenicity and tolerability of COVID-19 messenger RNA vaccines in primary immunodeficiency patients with functional B-cell defects기능적 B 세포 결함이 있는 원발성 면역결핍 환자에서 코로나19 메신저 RNA 백신의 면역원성과 내약성Multicenter Study Published on 2022-03-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] ACE2 ACE2 blocking antibody ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody deficiency Antibody Response Antibody responses B-cell blocking activity blocking antibody BNT162b2 BNT162b2 vaccine cellular immunity Clinical management cohort of patient common variable immunodeficiency coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA Vaccination COVID-19 vaccine trials detectable dose effective Efficacy enzyme evaluated functional Good Good syndrome help humoral Humoral response humoral responses IFN-γ IgG antibody IgG responses immune responses immunodeficiency immunogenicity information less mAb Messenger RNA Moderna mRNA mRNA vaccine mRNA vaccines mRNA-1273 neutralization not effective Patient patients Pfizer-BioNTech PID PIDs positive Primary immunodeficiencies Primary Immunodeficiency RBD RBD binding RBD-specific IgG responses Reactions reactogenicity Receptor binding domain referred to respiratory retrospective retrospective review Safe SARS-CoV-2 SARS-CoV-2 IFN-γ release assay SARS-CoV-2 spike protein SARS-CoV-2 spike protein antibody SARS-CoV-2 spike protein receptor binding domain SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD stimulated subject subjects T-cell immune response T-cell Response the spike protein Tolerability vaccination Vaccine was performed were excluded with COVID-19 [DOI] 10.1016/j.jaci.2021.11.022 PMC 바로가기 [Article Type] Multicenter Study
Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine407 Published on 2022-02-112022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect Alpha antibody antigens Apoptosis broad spectrum can be used CD8 Cell conserved coronavirus COVID-19 DCs deleted dendritic cell development domain effective Efficacy elicited Endoplasmic reticulum epitope expressed expression glycosite deletion glycosylation histocompatibility complex immune response incubated induce Messenger RNA MHC I Modification mRNA mRNA vaccine mRNA vaccines Omicron variants Pathogens Protective Protein provide RBD S2 domain SARS-CoV-2 SARS-CoV-2 spike protein Significance Spike protein Spread subunit T cell response the RBD the receptor-binding domain translated vaccination Vaccine variant variants of concern viral spike protein wild type XBP1 [DOI] 10.1073/pnas.2119995119 PMC 바로가기 [Article Type] 407
The Effectiveness of the Two-Dose BNT162b2 Vaccine: Analysis of Real-World Data2회 투여 BNT162b2 백신의 효과: 실제 데이터 분석Article Published on 2022-02-112022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted hazard ratio adjusted hazard ratios age analyzed assumed BNT162b2 BNT162b2 vaccine Chain Reaction clinical trial cohort study comparable coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dose Effectiveness evaluate Evidence first dose group Health Hospitalization Immunosuppressed immunosuppressed patients incidence incidence rate individual Infection males Messenger RNA Mortality mRNA occurred of BNT162b2 polymerase chain polymerase chain reaction preventing infection Primary outcome Randomized Randomized controlled trials reached real-time polymerase chain reaction real-world data reported RT-PCR SARS-CoV-2 SARS-COV-2 infection second dose severe acute respiratory syndrome Coronavirus shown the disease the vaccine Vaccine yielding [DOI] 10.1093/cid/ciab438 PMC 바로가기 [Article Type] Article
Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion423 Published on 2022-02-112022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 40S 5′ UTR Antisense oligonucleotide antiviral immunity block bypassing C-terminal domain circumvent Concentration conserved COVID-19 COVID-19 pandemic Critical drug resistance effective therapy evade expressing Health highly pathogenic Host host protein human ACE2 infected cell inhibit interfere maintain mechanism Messenger RNA mRNA mRNA stability nonstructural protein 1 nucleic acid pathogenicity presenting PROTECT protein trafficking Replication SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2–infected mice sequence Significance suppress susceptible targeting the SARS-CoV-2 therapeutic therapeutic target transgenic mice translation translational unique Vaccines variants variants of SARS-CoV-2 Viral protein viral replication virulence virus [DOI] 10.1073/pnas.2117198119 PMC 바로가기 [Article Type] 423
hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAsCoronaviruses Published on 2022-02-102022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] activate acute respiratory syndrome airway analysed Analysis biogenesis Calu-3 Calu-3 cell cells circRNA co-expression cognitive coronavirus Critical downstream epithelial expression facilitate form heterogeneous hnRNP C Host human lung immunoprecipitation increase Infection Interaction knockdown MERS-CoV MERS-CoV infection Messenger RNA Middle East modulate mRNA mRNAs mTOR inhibitor nuclear OSI-027 Pathogenesis pathway phosphorylated physically reduced viral loads Replication respiratory syndrome coronavirus ribonucleoprotein RNA RNA binding protein SARS-CoV-2 SARS-CoV-2 replication shown significantly Specific subset suppressed systemically upregulated viral infections virus [DOI] 10.1080/22221751.2022.2032372 PMC 바로가기 [Article Type] Coronaviruses
Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies혈액암 환자에서 mRNA-1273 SARS-CoV-2 백신의 세포 및 체액 면역원성Article Published on 2022-02-082022-09-12 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Active disease acute respiratory syndrome age anti-CD20 therapy Anti-SARS-CoV-2 S assays B-cell cellular cellular response coronavirus diagnosed disease Elecsy evaluate GVHD hematologic Hematologic malignancy humoral Humoral immunity humoral immunogenicity Humoral response immunoassay Immunosuppressive agents Immunosuppressive treatment implication interferon-γ LIAISON lymphopenia management Messenger RNA mRNA mRNA-1273 mRNA-1273 vaccine observation Patient patients patients treated preserved recent SARS-CoV-2 SARS-CoV-2 vaccine second dose shown T-cell T-cell Response the SARS-CoV-2 Treatment Vaccine were measured [DOI] 10.1182/bloodadvances.2021006101 PMC 바로가기 [Article Type] Article
Safety and tolerability of the COVID-19 messenger RNA vaccine in adolescents with juvenile idiopathic arthritis treated with tumor necrosis factor inhibitors종양 괴사 인자 억제제로 치료한 소아 특발성 관절염 청소년에서 COVID-19 메신저 RNA 백신의 안전성 및 내약성Article Published on 2022-02-012022-09-12 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] COVID-19 inhibitor juvenile idiopathic arthritis Messenger RNA Necrosis Safety Tolerability treated Vaccine [DOI] 10.1002/art.41977 PMC 바로가기 [Article Type] Article