Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2CXCR3+ 세포의 염증 유발 미세 환경 및 전신 축적은 SARS-CoV-2에 감염된 늙은 붉은털 원숭이의 폐 병리를 악화시킵니다.Article Published on 2021-09-012022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Apoptosis autophagy both lungs CD8+ cell CD8+ cells Cell cells changes in Chemokine receptor coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCR3 demonstrated elevated exacerbate feature FFPE formalin formalin-fixed paraffin-embedded IFN-α IL-6 immunopathological immunopathology infected with SARS-CoV-2 Infection Infectious diseases interferon interleukin interleukin 6 lung Lung pathology lung tissue Lungs microenvironment motif multiplex immunofluorescence NF-κB nuclear paraffin Peripheral blood pro-inflammatory protein expression Quantitative analysis respiratory rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 significantly staining T cell T-box tissue Treatment understanding [DOI] 10.1038/s41392-021-00734-w PMC 바로가기 [Article Type] Article
Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals인간과 동물의 SARS-CoV-2 변이체의 푸린 절단 부위에 대한 진화론적 통찰력Article Published on 2021-09-012022-09-11 Journal: Archives of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Affect Alter Amino acid Analysis analyzed B.1.1.7 B.1.1.7 isolate B.1.351 B.1.429 B.1.429 + B.1.427 B.1.525 binding cell tropism circulating variants cleavage database Deletion deletions Effect eight except for FCS Frequency furin furin cleavage site genetic polymorphisms GISAID GISAID initiative Human initiative investigated isolates Laboratory motif Multiple Mutation mutations P.1 P681H pathogenicity Point mutation predicted prevalent Q677H SARS-CoV-2 spike protein SARS-CoV-2 variant sequence Seven shown significantly spike Spike protein Spike protein sequence Surveillance Transmissibility USA variant variants virus transmissibility [DOI] 10.1007/s00705-021-05166-z PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte eliminationSARS-CoV-2 스파이크 단백질은 합포체 매개 림프구 제거를 지시합니다Article Published on 2021-09-012022-09-11 Journal: Cell Death and Differentiation [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-viral drug Anti-viral drugs cause cells cellular cellular structure contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy death expression identify induce inhibit lung tissue lung tissues lymphocyte Lymphocytes lymphocytopenia mechanism membrane fusion molecular motif patients polybasic prevalent respiratory S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike glycoprotein Structure structures Surface glycoprotein Syncytia syncytium target the SARS-CoV-2 therapy unique virus viruses [DOI] 10.1038/s41418-021-00782-3 PMC 바로가기 [Article Type] Article
The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19숙주의 면역 신호 인식에서 비피도박테리아의 PFNA 오페론의 역할: COVID-19 치료에서 FN3 단백질의 사용에 대한 전망Review Published on 2021-08-262022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, [키워드] addressed anti-inflammatory drug Anti-inflammatory drugs Bacteria bifidobacteria binding Cluster consequence core genes COVID-19 creation cytokine cytokine receptor Cytokine storms domain domains Evolution FIVE host immune system host-microbe interaction humans immune system immunomodulatory properties immunomodulatory property implicated implication Interaction mechanism microbial motif motifs operon over PFNA operon Protein protein kinase question Recognition resulting role SARS-COV-2 infection Serine species threonine TNF-α transmembrane region [DOI] 10.3390/ijms22179219 PMC 바로가기 [Article Type] Review
Homology between SARS CoV-2 and human proteinsArticle Published on 2021-08-252022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Autoimmune Autoimmune response Computational biology and bioinformatics contagiousness database dysfunction homologous human protein human proteins immune system indicate Infection innate immune system involved motif nonstructural protein olfactory ORF3a ORF7a ORF7b ORF8 Orf9b Organisms primary structure Protein protein domain proteome provoke provoking receptors SARS CoV-2 SARS-CoV-2 sequence similarity the S protein transmembrane domain virus [DOI] 10.1038/s41598-021-96233-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective ImmunityS1/S2 절단 부위에서 돌연변이를 갖는 SARS-CoV-2는 약화된 독성을 나타내고 보호 면역을 부여합니다Research Article Published on 2021-08-242022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] activate affecting airway animal model attenuation B.1.1.7 Bearing body weight Body weight loss cause cell tropism cellular entry cleavage cross-react exhibited furin furin cleavage site furin protease growth hamster hamsters Host immunogens infected with SARS-CoV-2 Infection Inflammatory response inoculated investigated Lineage lineages Mild motif mutant mutants Mutation Neutralizing antibodies P.1 parental Pathogenesis pathogenic pathway polybasic potential benefit potential benefits protective neutralizing antibodies protective neutralizing antibody proteolytic cleavage respiratory S gene S1/S2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Site spike Spike protein subsequent the spike protein tissue variant Viral viral growth weight loss [DOI] 10.1128/mBio.01415-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Proteins Bind to Hemoglobin and Its MetabolitesSARS-CoV-2 단백질은 헤모글로빈과 그 대사산물에 결합합니다Article Published on 2021-08-212022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adsorption affinity column Analysis analyzed approaches bind binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain explain FIVE hematological heme hemin hemoglobin identify in silico analysis in vitro inhibitory effect Interaction M metabolite Microarray motif motifs N N protein N-terminal domain Nsp3 Nsp7 NTD nucleoprotein peptide peptides Plaque assay Protein protein–protein binding Proteins proteomic Proteomic analysis proteomics protoporphyrin RBD RBD region receptor recruit recruitment Replication respiratory S protein SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus spike Spike protein suppressed the N protein the RBD the S protein the spike protein these compound these compounds Vero cells Viral viral replication virus was used [DOI] 10.3390/ijms22169035 PMC 바로가기 [Article Type] Article
Role of ATP in the RNA Translocation Mechanism of SARS-CoV-2 NSP13 HelicaseSARS-CoV-2 NSP13 헬리카제의 RNA 전위 메커니즘에서 ATP의 역할Article Published on 2021-08-122022-09-11 Journal: The journal of physical chemistry. B [Category] SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] antiviral target antivirals ATP binding characterized Clustering conserved Coronavirus infections COVID-19 pandemic demonstrated develop discriminant analysis domain Helicase identify investigated knowledge Linear Discriminant Analysis maintain mechanism mixture model molecular dynamics Molecular dynamics simulation motif nsp13 Numerous Population Protein protocol RNA role SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 nsp13 SF1 ssRNA Structure Support target Therapeutics translocate translocation treat Viral RNA was used [DOI] 10.1021/acs.jpcb.1c04528 PMC 바로가기 [Article Type] Article
The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients사이토카인 HGF와 CXCL13은 코로나19 환자의 중증도와 사망률을 예측한다Article Published on 2021-08-092022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] Admission anti-inflammatory properties anti-inflammatory property association B cell response best cellular chemokine Cohort cohorts Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL13 cytokine Cytokines death fibrosis Follow-up French hepatocyte growth factor HGF Host immune response ICU ICU admission identify immunological inflammatory pathways intensive care intensive care unit investigated Ligand likelihood Lung fibrosis lung tissue marker maturation mechanism Mortality motif Negative predictive value non-ICU non-ICU patients Occurrence over Patient patients pleiotropic positive power predict Predictive predictive values Prevent pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines pulmonary fibrosis reflect SARS-CoV-2 severe coronavirus disease severity significantly university up-regulation viral infection [DOI] 10.1038/s41467-021-25191-5 PMC 바로가기 [Article Type] Article
Entropy based analysis of SARS-CoV-2 spread in India using informative subtype markers유익한 하위 유형 마커를 사용하여 인도에서 SARS-COV-2 스프레드의 엔트로피 기반 분석Article Published on 2021-08-052022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] affected analysed Analysis China Computational biology and bioinformatics country COVID-19 D614G mutation death Diseases distribution Entropy European genetics genome sequence Geographic distribution GISAID India infected case Influenza information initiative marker motif New prevalent Region resulting SARS-CoV-2 SARS-CoV-2 genomes Spike protein Spread subtype temporal dynamics the SARS-CoV-2 genome the spike protein transferred unique Viral were infected [DOI] 10.1038/s41598-021-95247-5 PMC 바로가기 [Article Type] Article