Mouse Ifit1b is a cap1-RNA–binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1cImmunology Published on 2020-12-182022-10-30 Journal: The Journal of Biological Chemistry [Category] Coronavirus, [키워드] antiviral activity bind binding cells cofactor competing complex coronavirus Coronavirus infection facilitate higher eukaryotes Host host cell Human human infection IFIT1 IFIT3 Infection inhibit Innate immunity interferon-induced protein interferon-induced proteins with tetratricopeptide repeats (IFIT) Interpretation knockout lack Methylation mice Modification modulate mouse mouse model mRNA murine nucleotide orthologue plasticity Protein regulated restrict RNA RNA-binding protein rodents similarity stimulatory translation translation control viral immunology virus yielding [DOI] 10.1074/jbc.RA120.014695 PMC 바로가기 [Article Type] Immunology
Recombinant SARS-CoV-2 Spike Protein Mediates Glycolytic and Inflammatory Activation in Human MonocytesAbstracts Published on 2020-12-162022-10-30 Journal: Innovation in Aging [Category] COVID-19, [키워드] ACE2 receptor activate Activation acute respiratory syndrome cause caused cell lysate Contamination coronavirus disease Coronavirus-2 COVID-19 cytokine production Cytokine storm Donor Efficacy ELISA endotoxin Evidence Extracellular facilitate Glycolysis healthy human monocyte human monocytes Immune cell increase in Inflammation Inflammatory Inflammatory response Interaction interleukin-6 investigated marrow-derived macrophage metabolic monocyte mouse processed Protein protein expression qPCR Rapamycin recombinant SARS-CoV-2 SARS-CoV-2 spike protein Seahorse spike stimulated subunit the spike protein treating COVID-19 upregulation [DOI] 10.1093/geroni/igaa057.3493 PMC 바로가기 [Article Type] Abstracts
Deaminase-Independent Mode of Antiretroviral Action in Human and Mouse APOBEC3 ProteinsReview Published on 2020-12-122022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Action antiretroviral Antiviral APOBEC3 APOBEC3G Apolipoprotein B catalytic characterized combating cytosine deaminase-independent antiretroviral function enzyme function HIV-1 Human immature innate immune system Innate immunity intrinsic involved knowledge mode molecular mechanism molecular mechanisms mouse mRNA pathway Protein Replication restriction factor retrotransposons single-stranded DNA suppress tumorigenesis uracil virus [DOI] 10.3390/microorganisms8121976 PMC 바로가기 [Article Type] Review
Respiratory tissue-associated commensal bacteria offer therapeutic potential against pneumococcal colonization호흡기 조직 관련 공생 세균은 폐렴구균 집락 형성에 대한 치료 잠재력을 제공합니다.Article Published on 2020-12-082024-07-30 Journal: eLife [Category] 폐렴구균 감염증, [키워드] colonization resistance influenza A virus lactobacillus murinus Lung microbiome mouse Other Probiotics Streptococcus pneumoniae virus [DOI] 10.7554/eLife.53581 PMC 바로가기
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactionsBioGRID 데이터베이스: 선별된 단백질, 유전 및 화학적 상호작용의 포괄적인 생물의학 자원Tools for Protein Science Published on 2020-11-232022-09-10 Journal: Protein Science : A Publication of the Protein Soc [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome addition annotation BioGRID Biological biological network Biomedical research build can be used captures carried Cas9 cause cell lines cellular chemical interaction Community Complex network Complex networks COVID‐19 COVID‐19 CRISPR CRISPR screen CRISPR Screens curated database dataset datasets disease drug target drugs example experimental evidence extension facilitate generate Genetic genetic interaction genetic interactions genetic screens Health Human include Interaction interactions Modification mouse open organism phenotype post‐translational modification Protein protein interaction Regulation resource respiratory SARS‐CoV‐2 virus Screen Severe acute respiratory syndrome single mutant small molecule Small molecules species specific disease ubiquitin‐proteasome system worm yeast [DOI] 10.1002/pro.3978 PMC 바로가기 [Article Type] Tools for Protein Science
Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ FailurePharmacology Published on 2020-11-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity acute lung injury acute respiratory distress adverse event AEs Affect Alpha Anti-inflammatory anti-inflammatory agents ARDS Cancer clinical Clinical course Clinical practice clinical study Compliance complications coronavirus disease COVID-19 COVID-19 patient Cytokine release syndrome dose-dependent dose-escalation double-blind evaluate examined exhibited failure GRADE growth factor healthy histopathological examination Human ICH include Inflammatory cytokine ingredient interleukin-6 intravenous Liver damage Model mortality rate mouse multi-organ dysfunction multi-organ failure Necrosis New niacinamide Patient patients phosphate placebo-controlled platform Pneumonia potent Preclinical Prevent profile Protective Pulmonary edema Randomized reduce respiratory response Riboflavin SAEs Safety safety profile Sepsis Serious Adverse Event Shock show Standard statistical analysis subject subjects survival syndrome Tolerability Treatment was performed [DOI] 10.3389/fphar.2020.594321 PMC 바로가기 [Article Type] Pharmacology
NAIP–NLRC4-deficient mice are susceptible to shigellosisNAIP–NLRC4 결핍 마우스는 시겔라증에 취약하다.Article Published on 2020-10-192024-07-30 Journal: eLife [Category] 세균성이질, [키워드] Inflammasome mouse Other Shigella Shigellosis [DOI] 10.7554/eLife.59022 PMC 바로가기
Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury말라리아 동안의 대사 프로파일링은 신장 손상을 조절하는 아릴 탄화수소 수용체의 역할을 밝혀냅니다.Article Published on 2020-10-062024-08-11 Journal: eLife [Category] 말라리아, [키워드] Aryl hydrocarbon receptor malaria metabolism mouse [DOI] 10.7554/eLife.60165 PMC 바로가기
Animal models for the study of human hepatitis B and D virus infection: New insights and progressReview Published on 2020-10-012023-06-12 Journal: Antiviral Research [Category] B형 간염, [키워드] Hepatitis B virus Hepatitis D Virus hepatocyte mouse non-human primate Sodium taurocholate co-transporting polypeptide. [DOI] 10.1016/j.antiviral.2020.104898 [Article Type] Review
Cross-Protection against MERS-CoV by Prime-Boost Vaccination Using Viral Spike DNA and ProteinVaccines and Antiviral Agents Published on 2020-09-232022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] addition amino acids binding cause cell-mediated immune response Cellular immune response cellular receptor Combination Coronavirus vaccines Coronaviruses cross-neutralization cross-protection cross-protective demonstrated develop DNA DNA plasmid DNA viruses effective examined expected Heterologous high mortality human DPP4 humoral immunization immunized immunized mice induce interferon MERS-CoV mice Middle East mouse Mutation Neutralizing antibodies neutralizing antibody platform priming promote Protein provided RBD Recombinant protein regimen respiratory syndrome coronavirus RNA virus S-protein S-pseudovirion sequence sera severe respiratory illness spike spike glycoprotein strain subunit suggested the receptor-binding domain vaccination Vaccine Vaccine development Vaccines variant viral infection viral strain viruses wild-type [DOI] 10.1128/JVI.01176-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents