Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
Retrotransposon 활성화는 ALS의 Drosophila TDP-43 모델에서 신경 퇴행에 기여합니다
Research Article
[키워드] abnormality
accompanied
Activation
aggregation
ALS
Amyotrophic lateral sclerosis
Author
cascade
cause
cell death
cell types
cells
Characteristics
contribute
cytoplasmic
de-repression
death
degeneration
degenerative
disease
DNA
DNA binding protein
DNA damage
Drosophila
Effect
Effects
element
event
Evidence
expressed
expression
Familial
Genetic
Genome
Glia
glial cells
hallmark
human disease
impair
impairment
Inclusion
incurable
inhibiting
Lateral Sclerosis
lobar
locomotor
LTR
majority
mechanism
Mutation
neurodegeneration
neurodegenerative disorder
neurodegenerative disorders
Neuron
neuronal
neurons
nuclear protein
pathology
pathophysiological
phenotype
phenotypic
Premature
programmed cell death
PROTECT
Protein
repression
retrotransposon
retrotransposons
retrovirus
reverse transcriptase
RNA
RNA silencing
siRNA
Small interfering RNA
storm
subset
the disease
tissue
Toxicity
transcriptase
[DOI] 10.1371/journal.pgen.1006635 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1006635 PMC 바로가기 [Article Type] Research Article