H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic miceResearch Article Published on 2021-06-132022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, 신종인플루엔자, [키워드] activated addressed alternate infection antiviral therapeutics Characteristics convalescent stage COVID-19 pandemic distribution dose flu H1N1 H1N1 infection H1N1 virus hACE2 hACE2 transgenic mice in vivo Infection infection with SARS-CoV-2 infiltration influenza A virus lung lymphocyte mice observation pathologic patients PBMC public health risk SARS-CoV-2 SARS-COV-2 infection severe inflammation subsequent suppressed T cell tissue transgenic mice Vaccine viral shedding virus [DOI] 10.1080/22221751.2021.1938241 PMC 바로가기 [Article Type] Research Article
Identification of Lung and Blood Microbiota Implicated in COVID-19 PrognosisArticle Published on 2021-06-102022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] Analysis Anti-inflammatory BALF Blood blood microbiota Bronchoalveolar lavage fluid contribute coronavirus Coronavirus disease 2019 correlated COVID-19 COVID-19 prognosis COVID-19 severity cytokine downregulation identification IL-4 immune immune dysregulation implication Inflammation inflammatory pathway inflammatory pathways lung Lung microbiota microbe Microbiome mononuclear cell pathway PBMC Peripheral blood Prognosis SARS-CoV-2 Signaling signaling pathway therapy tissue treating COVID-19 patients upregulation [DOI] 10.3390/cells10061452 PMC 바로가기 [Article Type] Article
Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2어린 유아는 SARS-CoV-2에 대한 강력한 기능적 항체 반응과 억제된 IFN-γ 생산을 나타냅니다.Comparative Study Published on 2021-06-092022-09-12 Journal: Cell Reports Medicine [Category] MERS, 진단, [키워드] Abstract Adults Analysis anti-Spike IgG anti-spike IgG level antibody appear caused cellular cellular entry children comparable Control convalescent COVID-19 evaluate febrile illness Frequency functional functional antibody response help IFN-γ IgA IgA responses IgG immune response Immunity Infant Infants Mild mononuclear cell parent parents PBMC Peripheral blood PROTECT robust Saliva SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 spike protein sera seropositive serum Serum level severe COVID-19 severe disease statistically significant T cell the SARS-CoV-2 [DOI] 10.1016/j.xcrm.2021.100327 PMC 바로가기 [Article Type] Comparative Study
Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma controlArticle Published on 2021-06-042022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] ABCA1 ANLN approach Asthma asthma patient asthmatic asthmatic patient Asthmatic patients Biomarker Blood Bronchial epithelium Cell complex interplay Comprehensive derangement deviate downregulated driver examined Factor fibroblast fibroblasts Gene Expression GPRC5A healthy help heterogeneity homeostasis identify immunology in vitro KRT8 lung marker MKI67 molecular basis Molecular biology mononuclear cell NEK2 pathway Patient PBMC Peripheral blood phenotype progression proliferation qPCR recruited representing RRM2 SERPINE1 SFN Systems biology Th2 therapy tissue tissue remodeling TOP2A transcriptomic data upregulated validation were used wheeze [DOI] 10.1038/s41598-021-91087-5 PMC 바로가기 [Article Type] Article
Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease SeverityICU에 입원한 COVID-19 환자의 PBMC에서 손상된 세포독성 반응: 질병 중증도를 예측하는 바이오마커Immunology Published on 2021-05-262022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] Admission advance Algorithm analyzed association Biomarkers blood sample Blood samples cause CD4 CD8 lymphocytes + CD8+ T cell CD8+ T cells Cell cell population Cellular immune response center COVID-19 COVID-19 severity Critical cytotoxic cytotoxic cell cytotoxic response decrease develop effort elicit feature forest form hospitalized patients ICU IL-2 immune immune response immunological parameter Impaired infected cell infected cells Inflammatory response Invasive mechanical ventilation marker MHC class I MHC class I molecules NK and NKT cells NKT Novel coronavirus novel coronavirus SARS-CoV-2 pandemic parameter Patient PBMC plasma predict pseudotyped SARS-CoV-2 Random forest recruited reduce viral replication reduced response SARS-CoV-2 SARS-COV-2 infection Spain subpopulation susceptible T cell T cells target cell target cells Th1 the disease to define translated Tregs Viral viral replication [DOI] 10.3389/fimmu.2021.665329 PMC 바로가기 [Article Type] Immunology
Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19CD16+ 단핵구의 전사 변화가 COVID-19의 발병에 기여할 수 있음Immunology Published on 2021-05-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] analyzed Antigen presentation apoptotic caused CD16 CD16+ CD16+ monocyte CD16+ monocytes Cell cell activation cell movement change changes in characterized contribute contributing to COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic death dysregulated dysregulated immune response elevated expressed expression function functions gene signatures Genes healthy individual healthy individuals host response immune cells infiltration Inflammation Inflammatory Inflammatory response Inflammatory responses innate immune cell Innate immune cells interferon interferon response involved MHC class mild case mild cases mitochondrial Monocytes Non-classical monocytes Pathogenesis PBMC people with COVID-19 phenotype RNA sequencing data SARS-CoV-2 Severe case severe cases severity severity of COVID-19 Single Cell Single-cell transcriptomics the disease These cells tissue repair tissues transcriptional change Transcriptional changes transcriptomic upregulated upregulation Viral viral infections [DOI] 10.3389/fimmu.2021.665773 PMC 바로가기 [Article Type] Immunology
Highly conserved, non-human-like, and cross-reactive SARS-CoV-2 T cell epitopes for COVID-19 vaccine design and validationArticle Published on 2021-05-132022-10-04 Journal: NPJ Vaccines [Category] 변종, 임상, 치료기술, [키워드] Antibody Response circulating Cohort collected conserved convalescent Coverage COVID-19 vaccine design cross-reactive cross-reactivity defined demonstrated described Direct epitope Epitopes facilitate HLA HLA-DR3 Human immunization IMPROVE individuals membrane memory response natural PBMC peptide peptide epitope Peptide vaccines predicted required Respiratory disease robust SARS-CoV-2 SARS-CoV-2 immunity selected Support T cell T cell epitope T-cell T-cell epitope T-cell immunity T-cell Response Th2 the SARS-CoV-2 Transgenic mouse Transmission Vaccine Vaccine-induced immunity viral infection virus virus-infected cells [DOI] 10.1038/s41541-021-00331-6 PMC 바로가기 [Article Type] Article
Interplay between SARS‐CoV‐2 and human long non‐coding RNAsShort Communication Published on 2021-05-092022-10-29 Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] BALF binding Bronchoalveolar lavage fluid Cis regulation contributed COVID‐19 patient COVID‐19 Critical drug Efficiency exhibited Genome healthy individuals high affinity host response HOTAIRM1 infected cells Inflammation Interaction lncRNA long non‐coding RNA MALAT1 mononuclear cell NEAT1 overcome pandemic PBMC Peripheral blood PVT1 Regulatory RNA RNA sequencing data SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 genome Side effect trans regulation Transcriptome Vaccine viral infection [DOI] 10.1111/jcmm.16596 PMC 바로가기 [Article Type] Short Communication
Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine StormImmunology Published on 2021-04-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation Against anaphylatoxins Anti-inflammatory autologous bacterial lipopolysaccharide C3a C5a CAR-T cell therapy Clinical use complement complement activation/inhibition complement inhibitors consequence COVID-19 cytokine release Cytokine release syndrome Cytokines differential inhibition EDTA Effect Factor H heat inactivation identify IL-10 IL-12 IL-13 IL-1α IL-1β IL-5 IL-6 IL-7 IL-8 immune immune stimulation impacts in vitro in vitro study inhibition innate immune innate immune system life-threatening LPS marker mononuclear cell PBMC PBMCs Peripheral blood Potential Proinflammatory cytokine Release SC5b-9 secretion serum storm subsequent therapy TNFα utility Viral diseases whole blood assay zymosan [DOI] 10.3389/fimmu.2021.642860 PMC 바로가기 [Article Type] Immunology
Identification of PBMC-based molecular signature associational with COVID-19 disease severityResearch article Published on 2021-04-212022-10-05 Journal: Heliyon [Category] 바이오마커, [키워드] administration admitted to ICU affected Analysis antiviral response associational Biomarker Biomarkers canonical clinical implications coding mRNA COVID-19 COVID-19 patient dataset disease disease severity Effect expressed function global pandemic identification implication individual interferon lncRNA long noncoding RNA molecular mRNA Non-COVID-19 Patient patients patients with COVID-19 PBMC PBMCs Protein SARS-CoV-2 severe COVID-19 severity significantly Stratification subset suppressed Therapeutic approach therapeutic option therapy Transcriptome turn upstream with COVID-19 [DOI] 10.1016/j.heliyon.2021.e06866 [Article Type] Research article