Genetic Correlates of Psychological Responses to the COVID-19 Crisis in Young Adult Twins in Great Britain영국의 젊은 성인 쌍둥이에서 COVID-19 위기에 대한 심리적 반응의 유전적 상관 관계Original Research Published on 2021-02-242022-09-10 Journal: Behavior Genetics [Category] MERS, 유전자 메커니즘, [키워드] accounted Adults affected Analysis average behavioural change changes changes in commenced correlated correlation COVID-19 COVID-19 crisis crisis Depression England environmental factor expected Factor Genetic genetic factor genetic factors Genetic influences Great Britain Hypothesis Individual differences influence influences on Interaction investigated Life satisfaction lockdown magnitude phenotypic Psychological Psychological stress psychologically Psychopathology response Response to global pandemic stability supplementary material traits twin [DOI] 10.1007/s10519-021-10050-2 PMC 바로가기 [Article Type] Original Research
Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation기계적 환기가 필요한 환자에서 나이가 들수록 안지오텐신 전환 효소 2(ACE2) 발현이 증가합니다.Research Article Published on 2021-02-162022-09-10 Journal: PLoS ONE [Category] MERS, 유전자 메커니즘, [키워드] ACE2 ACE2 distribution ACE2 expression ACE2 protein ACE2 receptor acute hypoxic respiratory failure advanced age Affect affecting age AHRF alveolar damage Alveolar macrophages Alveolar Type II AT2 Cell cells cellularity change Cohort collected contribute Critical Diffuse alveolar damage enzyme Examining expression feature histologic hospital Host human lung hypoxic respiratory failure IHC immunohistochemistry increase individuals Infection investigated Lower respiratory tract lower respiratory tract infection lung macrophages mechanical ventilation Mortality normalized on mechanical ventilation parameter Patient phenotypic potential mechanism profile protein expression reactive receiving respiratory Respiratory failure RNA RNA sequencing data SARS-CoV-2 selected specimen tissues Type II pneumocyte type II pneumocytes upregulated Ventilated Ventilation [DOI] 10.1371/journal.pone.0247060 PMC 바로가기 [Article Type] Research Article
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity420 Published on 2021-02-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, [키워드] Adaptive immune response alteration Analysis Cell circulating Cluster contribute COVID-19 COVID-19 severity DCs decrease decreased expression disease dysregulation effort Frequency Immune cell immunopathology Infection Lineage Major MNP moderate monocyte Monocytes mononuclear phagocyte nonsurvivors Patient performed phenotypic pre-DCs precursors provide response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–infected patient severe COVID-19 severely sick patients severity Significance subset these cell viral infection while with COVID-19 [DOI] 10.1073/pnas.2018587118 PMC 바로가기 [Article Type] 420
Effect of An 84-bp Deletion of the Receptor-Binding Domain on the ACE2 Binding Affinity of the SARS-CoV-2 Spike Protein: An In Silico AnalysisArticle Published on 2021-01-292022-10-31 Journal: Genes [Category] COVID-19, [키워드] ACE2 ACE2 receptor affected affinity Attenuated attribute binding Co-infection contribute coronavirus Coronaviruses COVID-19 pandemic Deleterious Deletion dominant Effect element Evolution facilitate future therapeutic genetic alterations Genome genomic homology model Hungary mutant Mutation Patient phenotypic Protein RBD Receptor binding domain recessive Research responsible SARS-CoV-2 SARS-CoV-2 virus Selection Sequencing spike spike-mutant strain the RBD the SARS-CoV-2 the Spike variant virus [DOI] 10.3390/genes12020194 PMC 바로가기 [Article Type] Article
Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence신호 전달 경로 내 및 사이의 다면발광 및 상위성은 진균 독성의 유전적 구조를 정의합니다Research Article Published on 2021-01-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect amphotericin B Analysis antifungal drug resistance approach Author avirulent body temperature CAMP cascade Cell Cell signaling cellular cellular response Cellular responses characterization Combination complex component contribute cross Cryptococcal disease Cryptococcus cyclic AMP disease drug susceptibility drugs ENCODE epistatic interaction Europe Extracellular fungal Genes Genetic genetic architecture genetic difference genetic differences Genetic variation glycerol growth highlight human body Infection information isolate kinase Lineage locus make up mapping microbial modify molecular nucleotide osmolarity osmotic oxidative oxidative stress oxidative stress resistance pathogen pathogenicity Pathogens pathway phenotypic phenotypic variation physiological response pleiotropic polysaccharide capsule progeny promote protein kinase QTL Quantitative quantitative trait locus regulate regulator sensitivity Signal transduction Signaling signaling pathway strain Strains Stress temperate climates thought Tolerance traits underlie Variation virulence virulent [DOI] 10.1371/journal.pgen.1009313 PMC 바로가기 [Article Type] Research Article
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus서아프리카 Anopheles의 pirimiphos-methyl에 대한 내성은 Ace1 유전자좌의 복제 및 유전자이입을 통해 확산되고 있습니다.Research Article Published on 2021-01-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] ACE1 acetylcholinesterase African Analysis Anophele Anopheles gambiae approach association Carbamate Combination complex Control copy number diagnostic dominant driven by duplication duplications effective Effectiveness enzyme Genetic genomes genomic Haplotype highlight increasingly insecticidal insecticide insecticides Intervention locus malaria malaria vector molecular Mutation Non-synonymous occur organophosphate overcome phenotypic pirimiphos-methyl Population populations Predictive Predictive value predictor Prevent provide public health reduce Replication resistance resistance mechanism resistance mechanisms selection pressure sequenced specimen Spread sub-Saharan Africa Surveillance transferred Transmission unique Variation vector vectors West whole genome [DOI] 10.1371/journal.pgen.1009253 PMC 바로가기 [Article Type] Research Article
Molecular Mechanisms of Vascular Damage During Lung Injury폐 손상 중 혈관 손상의 분자 메커니즘Review Published on 2021-01-012022-09-11 Journal: Advances in experimental medicine and biology [Category] 유전자 메커니즘, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ADRS alveolar epithelium ARDS association behavioral risk factors change contribute COVID-19 Cytokines damage disease disease risk Disruption DNA DNA methylation endothelial activation Enzyme inhibitor Enzyme inhibitors Epigenetic epigenetics epithelial Epithelial barrier evaluate experimental model experimental models explained Factor focus Genetic genetic factors Genetic polymorphism genetic polymorphisms Genetic predisposition high mortality rate histone Histone acetylation, DNA methylation Hospitalization humans increased vascular permeability Inflammation Inflammatory response Injury intensive care lung endothelial Lung injury mechanism Modification molecular mechanism molecular mechanisms Mortality occur offer Pathogenesis phenotypic potential therapeutic target Prevent pro-inflammatory cytokines promote Research respiratory distress Respiratory distress syndrome Risk factors susceptibility syndrome systemic and local treat variety Vascular damage Vascular endothelium vascular permeability [DOI] 10.1007/978-3-030-68748-9_6 PMC 바로가기 [Article Type] Review
Pulmonary pathology of ARDS in COVID-19: A pathological review for cliniciansCOVID-19에서 ARDS의 폐 병리: 임상의를 위한 병리학적 검토Review Published on 2021-01-012022-09-12 Journal: Respiratory medicine [Category] MERS, SARS, 진단, [키워드] acute lung injury acute respiratory distress alveolar-capillary barrier ARDS binding cell receptor characterized Clinical findings clinician Compliance correlation COVID-19 Critical cytoplasm DAD Diagnosis Diffuse alveolar damage domain endothelial cells epithelial cell Evolution expression flu-like symptoms Gas exchange host cells hyaline membrane formation Hypoxemia Inflammatory Intersection knowledge mechanism modulated molecular molecular mechanism Molecular pathology pandemic pathology pathophysiological pathway Patient phenotypic Protein Proteins pulmonary Pulmonary pathology radiological reached reduced Replication reported responsible RNA viruses SARS-CoV-2 SARS-COV-2 infection Symptom syndrome the disease thrombosis transcribed Transcription Treatment vascular permeability viral genome viral infection virus with COVID-19 [DOI] 10.1016/j.rmed.2020.106239 PMC 바로가기 [Article Type] Review
Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes최전선 과학: COVID-19 감염은 말초 혈액 단핵구에서 쉽게 감지할 수 있는 형태학적 및 염증 관련 표현형 변화를 유도합니다Multicenter Study Published on 2021-01-012022-09-11 Journal: Journal of leukocyte biology [Category] SARS, 바이오마커, 치료기술, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome Admission Analysis ARDS CD14 CD16 CD80 changes in clinical utility controls COVID-19 COVID-19 infection COVID-19 patient cytokine Cytokine storm detect detectable expression Factor feature Flow cytometric analysis flow cytometry forward scatter FSC FSC-high functional healthy individuals help Hospitalization ICU identify IL-10 IL-6 induce infection with COVID-19 inflammatory monocyte inflammatory monocytes intensive care intensive care unit intervene Lung injury M1/M2 macrophage Macrophage macrophage polarization monocyte Monocytes morphology outcome Patient patients with COVID-19 performed Peripheral blood peripheral blood samples phenotypic predict recognize respiratory distress Respiratory distress syndrome risk secretion Severity of disease side scatter significant difference significant differences subsequent subset syndrome TNF-α Treatment with COVID-19 [DOI] 10.1002/JLB.4HI0720-470R PMC 바로가기 [Article Type] Multicenter Study
SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsetsSARS-CoV-2 감염은 순환 단핵구에서 혼합 M1/M2 표현형을 유도하고 수지상 세포 및 단핵구 하위 집합 모두에서 변경을 유도합니다Clinical Trial Published on 2020-12-312022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] activated Activation adoptive immunity alteration Analysis B lymphocytes Cell center circulating monocyte clinical Clinical Center clinical manifestation clinical manifestations COVID-19 patient cytometric dendritic cell dendritic cells event expressed Flow Flow cytometric analysis functional highlight Immunity immunological indicated induce Innate immunity less low expression lymphocyte Lymphocytes M1 and M2 monocytes M2 marker M2 monocyte M2 monocytes marker Mild mild case mild cases Mild symptom mild symptoms monocyte Monocytes myeloid NK cell NK cells Patient Peripheral blood peripheral blood cell peripheral blood cells phenotype phenotypic preserved proportion recruited SARS-COV-2 infection severe cases severe disease severe symptom severity subset Symptom T and B lymphocytes the disease was performed [DOI] 10.1371/journal.pone.0241097 PMC 바로가기 [Article Type] Clinical Trial